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Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome
22q11.2 Deletion Syndrome (22q11.2DS) is the strongest known molecular risk factor for schizophrenia. Brain responses to auditory stimuli have been...
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Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia
Genome-wide association studies (GWASs) have reported multiple single nucleotide polymorphisms (SNPs) associated with schizophrenia, yet the...
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Circadian rhythmicity in schizophrenia male patients with and without substance use disorder comorbidity
Circadian rhythmicity is associated to clinical variables that play an important role in both schizophrenia (SZ) and substance use disorders (SUD),...
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Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism
The enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) plays a pivotal role in the regulation of nitric oxide levels by degrading the main...
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Behavioral manifestations in rodent models of autism spectrum disorder: protocol for a systematic review and network meta-analysis
BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental condition associated with severe social communication, interaction, and sensory...
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Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study
The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia....
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Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study
BackgroundCognitive functions represent useful endophenotypes to identify the association between genetic variants and schizophrenia. In this sense,...
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Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset and progression and have potential to produce clinically useful...
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Genetic Influences on Alcohol Sensitivity: a Critical Review
Purpose of ReviewThe present review provides a summary of the progress that genome-wide association studies (GWAS) have made in identifying the...
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Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations
Alcohol use behaviors are highly heterogeneous, posing significant challenges to etiologic research of alcohol use disorder (AUD). Magnetic resonance...
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Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment
Purpose of ReviewThis review summarizes neurotransmitter, peptide, and other neurohormone abnormalities associated with posttraumatic stress disorder...
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Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype
Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the...
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TRPM8 genetic variant is associated with chronic migraine and allodynia
BackgroundMany single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their...
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Association of verbal and non-verbal theory of mind abilities with non-coding variants of OXTR in youth with autism spectrum disorder and typically developing individuals: a case-control study
BackgroundThe ability to attribute mental states to others is called theory of mind (ToM) and is a substantial component of social cognition. This...
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In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and cortical development
Williams syndrome (WS) is a neurodevelopmental disorder caused by a heterozygous micro-deletion in the WS critical region (WSCR) and is characterized...
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Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function
βB2-crystallin (gene symbol: Crybb2 / CRYBB2 ) was first described as a structural protein of the ocular lens before it was detected in various brain...
