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Evolution of tissue-specific expression of ancestral genes across vertebrates and insects
Regulation of gene expression is arguably the main mechanism underlying the phenotypic diversity of tissues within and between species. Here we...
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Tissue-specific roles of peroxisomes revealed by expression meta-analysis
Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis...
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Early expression onset of tissue-specific effector genes during the specification process in sea urchin embryos
BackgroundIn the course of animal developmental processes, various tissues are differentiated through complex interactions within the gene regulatory...
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Inducible, Tissue-Specific Gene Expression in Arabidopsis Using GR-LhG4-Mediated Trans-Activation
Inducible, tissue-specific gene expression is a potent tool to study gene regulatory networks as it allows spatially and temporally controlled...
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Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology...
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Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues
BackgroundTissue non-specific alkaline phosphatase (TNSALP; encoded by the ALPL gene) has a critical role in the postnatal regulation of phosphate...
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Tissue-specific isoform expression of GNE gene in human tissues
Mutations in the sialic acid biosynthesis enzyme GNE lead to a late-onset, debilitating neuromuscular disorder, GNE myopathy, characterized by...
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Reduced Expression of the Tissue-Specific Oct-1L Isoform Exerts an Antitumor Effect on Namalwa Burkitt’s Lymphoma Cells
Abstract—Increased expression levels of the Oct-1 transcription factor is considered to be one of the key markers of poor cancer prognosis. In...
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LDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data
Genome-wide association studies have identified thousands of genetic susceptibility loci associated with cancer as well as other traits and diseases....
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Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer
IntroductionUnderstanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes...
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Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns
BackgroundDeciphering gene regulation is essential for understanding the underlying mechanisms of healthy and disease states. While the regulatory...
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Adipose tissue depot specific expression and regulation of fibrosis-related genes and proteins in experimental obesity
Transforming growth factor beta (Tgfb) is a well-studied pro-fibrotic cytokine, which upregulates cellular communication network factor 2 ( Ccn2 ), collagen...
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Inference and prioritization of tissue-specific regulons in Arabidopsis and Oryza
A regulon refers to a group of genes regulated by a transcription factor binding to regulatory motifs to achieve specific biological functions. To...
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Chronic hypoxia and hyperoxia alter tissue-specific fatty acid profile and FD6D and elongase gene expression levels in rainbow trout (Oncorhynchus mykiss)
Commercially important trout species, especially rainbow trout, are under great threat due to several negative factors affecting oxygen levels in...
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5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt’s Lymphoma Cell Culture
AbstractOverexpression of the transcription factor POU2F1 (Oct-1) increases the malignant potential of the tumor and determines the unfavorable...
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Robust and rigorous identification of tissue-specific genes by statistically extending tau score
ObjectivesIn this study, we aimed to identify tissue-specific genes for various human tissues/organs more robustly and rigorously by extending the...
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Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin
BackgroundEvolutionary conservation is an invaluable tool for inferring functional significance in the genome, including regions that are crucial...
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Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to...
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Tissue-Specific Expression of Neurexin-1α Isoforms in Rat Organs
Abstract—Neurexins are a family of synaptic adhesion proteins that play a key role in synapse formation and maintenance. Neurexins undergo extensive...
