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Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction
Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most...
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Crosstalk between protein post-translational modifications and phase separation
The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current...
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Detection of phosphorylation post-translational modifications along single peptides with nanopores
Current methods to detect post-translational modifications of proteins, such as phosphate groups, cannot measure single molecules or differentiate...
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Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases
Protein post-translational modifications (PPTMs) refer to a series of chemical modifications that occur after the synthesis of protein. Proteins...
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Roles of post-translational modifications of UHRF1 in cancer
UHRF1 as a member of RING-finger type E3 ubiquitin ligases family, is an epigenetic regulator with five structural domains. It has been involved in...
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ISGylation of DRP1 closely balances other post-translational modifications to mediate mitochondrial fission
Dynamin related protein 1 (DRP1), a pivotal mitochondrial fission protein, is post-translationally modified by multiple mechanisms. Here we identify...
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Post-translational modifications on the metal-sequestering protein calprotectin
Human calprotectin (CP, S100A8/S100A9 oligomer) is an abundant neutrophil protein that contributes to innate immunity by sequestering nutrient metal...
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Post-translational Modifications in Parkinson’s Disease
Parkinson’s disease (PD) is a complex neurodegenerative disorder characterised by progressive degeneration of the dopaminergic neurons in the...
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DNA methylation and histone post-translational modifications in atherosclerosis and a novel perspective for epigenetic therapy
Atherosclerosis, which is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls, acts as the important...
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Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation
AbstractReactive oxygen species (ROS) are constantly generated in a living organism. An imbalance between the amount of generated reactive species in...
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Post-Translational Modifications During Brain Development
Several classes of post-translational modifications (PTMs) regulate various processes that occur during neurodevelopment. The first of these...
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Post-translational modifications: emerging regulators manipulating jasmonate biosynthesis and signaling
Jasmonate (JA) is one of the key phytohormones essential for plant development and defense processes. The core JA biosynthetic and signaling pathways...
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Mining proteomics data to extract post-translational modifications associated with gastric cancer
Gastric cancers are highly heterogeneous, deep-seated tumours associated with late diagnosis and poor prognosis. Post-translational modifications...
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MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations
Necroptosis is a caspase-independent modality of cell death that requires the activation of the executioner MLKL. In the last ten years the field...
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Diversity of post-translational modifications and cell signaling revealed by single cell and single organelle mass spectrometry
The rapid evolution of mass spectrometry-based single-cell proteomics now enables the cataloging of several thousand proteins from single cells. We...
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Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction
This review provides an update on recent findings from basic, translational, and clinical studies on the molecular mechanisms of mitochondrial...
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Post-translational Modifications in Brain Diseases: A Future for Biomarkers
Several omic fields have been used in the development of biomarker panels, most traditionally involving genetics and proteomics. The...
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Unconventional protein post-translational modifications: the helmsmen in breast cancer
Breast cancer is the most prevalent malignant tumor and a leading cause of mortality among females worldwide. The tumorigenesis and progression of...
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Post-translational modifications reshape the antigenic landscape of the MHC I immunopeptidome in tumors
Post-translational modification (PTM) of antigens provides an additional source of specificities targeted by immune responses to tumors or pathogens,...
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Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period
We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them...
