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G•U wobble base pairs improve site-directed RNA base editing
Improving the precision of gene correction through RNA base editing typically involves a trade-off with efficiency. We find using G•U wobble base pairs is a universally applicable strategy to improve editing precision and efficiency, and is effective in a mouse model of Rett syndrome in vivo.
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![Illustration of female doctor and patient talking about female health](https://cdn.statically.io/img/media.springernature.com/lw630/nature-cms/uploads/collections/F-health-hero-97b93489c3c712a896bd99059e342094.jpg)
A spotlight on women’s health
Here we profile companies developing innovations for women’s health, a relatively underfunded market with few treatment options available for many conditions.
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Programming tumor evolution with selection gene drives to proactively combat drug resistance
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Template-independent enzymatic synthesis of RNA oligonucleotides
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A community effort to track commercial single-cell and spatial ’omic technologies and business trends
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Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA