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The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These...
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Intrinsically disordered regions in TRPV2 mediate protein-protein interactions
Transient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na + , Ca 2+ ) regulating...
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Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases....
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Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions
An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum...
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Computational Methods to Predict Intrinsically Disordered Regions and Functional Regions in Them
Intrinsically disordered regions (IDRs) are protein regions that do not adopt fixed tertiary structures. Since these regions lack ordered...
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Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases
We studied diverse prenylated intrinsically disordered regions (PIDRs) of Ras and Rho family small GTPases using long timescale atomistic molecular...
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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy
Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that form neither helix, sheet, nor any other canonical...
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Conformational buffering underlies functional selection in intrinsically disordered protein regions
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms...
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Insights into Membrane Curvature Sensing and Membrane Remodeling by Intrinsically Disordered Proteins and Protein Regions
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate their shape to perform various cellular functions. The...
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone...
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Chaotic aging: intrinsically disordered proteins in aging-related processes
The development of aging is associated with the disruption of key cellular processes manifested as well-established hallmarks of aging. Intrinsically...
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Computational Study of Conformational Changes in Intrinsically Disordered Regions During Protein-Protein Complex Formation
Intrinsically Disordered Regions (IDRs) even though they cannot form a defined three-dimensional structure play a pivotal role in modulating cellular...
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Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a range of functional roles. While folded domains are...
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Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs
Paralogs, arising from gene duplications, increase the functional diversity of proteins. Protein functions in paralog families have been extensively...
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Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying ageing, is a current and...
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Approaches for the Identification of Intrinsically Disordered Protein Domains
Intrinsically disordered protein domains are those with high disorder proportion or a consecutive disordered region. They have no stable spatial...
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Diversity of hydrodynamic radii of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a...
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In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein
Proteins containing intrinsically disordered regions (IDRs) control a wide variety of cellular processes by assembly of membrane-less organelles via...
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Protein intrinsically disordered region prediction by combining neural architecture search and multi-objective genetic algorithm
BackgroundIntrinsically disordered regions (IDRs) are widely distributed in proteins and related to many important biological functions. Accurately...
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Remodeling of the Plasma Membrane by Surface-Bound Protein Monomers and Oligomers: The Critical Role of Intrinsically Disordered Regions
The plasma membrane (PM) of cells is a dynamic structure whose morphology and composition is in constant flux. PM morphologic changes are...
