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Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases....
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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy
Intrinsically disordered proteins (IDPs) are comprised of significant numbers of residues that form neither helix, sheet, nor any other canonical...
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone...
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Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying ageing, is a current and...
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Chaotic aging: intrinsically disordered proteins in aging-related processes
The development of aging is associated with the disruption of key cellular processes manifested as well-established hallmarks of aging. Intrinsically...
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Diversity of hydrodynamic radii of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a...
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Optimal 13C NMR investigation of intrinsically disordered proteins at 1.2 GHz
Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for characterizing biomolecules such as proteins and nucleic acids at atomic...
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IDPsBind: a repository of binding sites for intrinsically disordered proteins complexes with known 3D structures
BackgroundIntrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles in...
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Intrinsically disordered proteins play diverse roles in cell signaling
AbstractSignaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca 2+ or chemokine proteins) and physical stimuli...
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The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These...
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Approaches for the Identification of Intrinsically Disordered Protein Domains
Intrinsically disordered protein domains are those with high disorder proportion or a consecutive disordered region. They have no stable spatial...
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Insights into Membrane Curvature Sensing and Membrane Remodeling by Intrinsically Disordered Proteins and Protein Regions
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate their shape to perform various cellular functions. The...
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Artificial intelligence guided conformational mining of intrinsically disordered proteins
Artificial intelligence recently achieved the breakthrough of predicting the three-dimensional structures of proteins. The next frontier is presented...
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Intrinsically disordered regions in TRPV2 mediate protein-protein interactions
Transient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na + , Ca 2+ ) regulating...
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Dynamic structures of intrinsically disordered proteins related to the general transcription factor TFIIH, nucleosomes, and histone chaperones
Advances in structural analysis by cryogenic electron microscopy (cryo-EM) and X-ray crystallography have revealed the tertiary structures of various...
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Intrinsically Disordered Proteins (IDP): Purification Under Denaturing Conditions
Recombinant protein expression in E. coli often induces the expressed protein to accumulate in insoluble aggregates, named inclusion bodies (IBs),...
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Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a range of functional roles. While folded domains are...
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Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions
An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum...
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Contact-Based Analysis of Aggregation of Intrinsically Disordered Proteins
We review the contact-based description of aggregation of intrinsically disordered proteins in coarse-grained and all-atom models. We consider...
