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Exact Matching
We’re already seen that alignments contain exact matches. So far we haven’t made use of this—even when comparing two identical sequences, we filled...
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Exact Matching
We change into the directory holding the chapters, make directory 3 for the new chapter, change into it, make directory 1, and change into that.
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ESKEMAP: exact sketch-based read mapping
BackgroundGiven a sequencing read, the broad goal of read mapping is to find the location(s) in the reference genome that have a “similar sequence”....
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Finding maximal exact matches in graphs
BackgroundWe study the problem of finding maximal exact matches (MEMs) between a query string Q and a labeled graph G . MEMs are an important class...
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Mathematical Modeling: Does Landscape Science Need to Become an Exact Science?
Purpose of ReviewIn this article, I consider how ideas about the role of mathematics in the formation of landscape studies as those lying between...
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Exact Linear Reduction for Rational Dynamical Systems
Detailed dynamical systems models used in life sciences may include dozens or even hundreds of state variables. Models of large dimension are not...
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Uncovering hidden network architecture from spiking activities using an exact statistical input-output relation of neurons
Identifying network architecture from observed neural activities is crucial in neuroscience studies. A key requirement is knowledge of the...
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The function of Sec1/Munc18 proteins – Solution of the mystery in sight?
Members of the Sec1/Munc18 (SM) protein family form a central part of the machinery responsible for transport vesicle docking and fusion. Their...
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Global exact optimisations for chloroplast structural haplotype scaffolding
BackgroundScaffolding is an intermediate stage of fragment assembly. It consists in orienting and ordering the contigs obtained by the assembly of...
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Estrogenic endocrine disruptor exposure directly impacts erectile function
Erectile dysfunction (ED) is an extremely prevalent condition which significantly impacts quality of life. The rapid increase of ED in recent decades...
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Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants
N-methyl-D-aspartate receptors (NMDARs emerging from GRIN genes) are tetrameric receptors that form diverse channel compositions in neurons,...
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Function of snail shell hairs in anti-predator defense
The function and evolutionary background of the hairs on the shells of terrestrial gastropods is largely unknown. Many hypotheses proposed by...
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The Ancient Origin and Function of Germline Cysts
Gamete production in most animal species is initiated within an evolutionarily ancient multicellular germline structure, the germline cyst, whose...
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An oscillating reaction network with an exact closed form solution in the time domain
BackgroundOscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important...
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PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
PAQR4 is an orphan receptor in the PAQR family with an unknown function in metabolism. Here, we identify a critical role of PAQR4 in maintaining...
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Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for...
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What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand...
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Prediction of delayed graft function by early salivary microbiota following kidney transplantation
AbstractDelayed graft function (DGF) is a frequently observed complication following kidney transplantation (KT). Our prior research revealed dynamic...
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Transfer RNA Fragments, from Structure to Function
Transfer RNA molecules (tRNAs) are produced from numerous nuclear and mitochondrial genes and are primarily involved in bringing specific amino acid...
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Spaceflight effects on human vascular smooth muscle cell phenotype and function
The cardiovascular system is strongly impacted by the hazards of spaceflight. Astronauts spending steadily increasing lengths of time in microgravity...
