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Embryonic exposure to decitabine induces multiple neural tube defects in developing zebrafish
Neural tube defects are severe congenital disorders of the central nervous system that originate during embryonic development when the neural tube...
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Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia...
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AICAR suppresses cell proliferation and synergizes with decitabine in myelodysplastic syndrome via DNA damage induction
ObjectiveTo investigate the efficacy and safety of the AMPK activator AICAR alone or in combination with decitabine on myelodysplastic syndromes...
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Decitabine bioproduction using a biocatalyst with improved stability by adding nanocomposites
A novel IDA- La NDT derivative was able to reach the highest productivity in the biosynthesis of a well-known antitumoral agent called decitabine....
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The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer
Three-dimensional (3D) epigenome remodeling is an important mechanism of gene deregulation in cancer. However, its potential as a target to...
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Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer
BackgroundPreviously, we reported lower RSK4 mRNA and protein levels in malignant ovarian tumors compared to normal and benign ovarian tissues. Also,...
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Epigenetically modified AP-2α by DNA methyltransferase facilitates glioma immune evasion by upregulating PD-L1 expression
Programmed death-ligand 1 (PD-L1) ensures that tumor cells escape T-cell-mediated tumor immune surveillance. However, gliomas are characteristic of...
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Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice
BackgroundMesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the...
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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells
BackgroundDNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and...
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Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation
BackgroundDNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is not very clear....
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Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells
BackgroundThe most significant cause of treatment failure in chronic myeloid leukemia (CML) is a persistent population of minimal residual cells....
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Clinical Studies and Epi-Drugs in Various Cancer Types
Cancer is characterized by modifications in the epigenetic mechanisms and chromatin functions. Alterations in gene expression, as well as the...
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DNA methylation atlas and machinery in the developing and regenerating annelid Platynereis dumerilii
BackgroundMethylation of cytosines in DNA (5mC methylation) is a major epigenetic modification that modulates gene expression and constitutes the...
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Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
Epigenetic plasticity is a pivotal factor that drives metastasis. Here, we show that the promoter of the gene that encodes the ubiquitin ligase...
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Epigenetic Alterations in Hematologic Malignancies
Epigenetic control is necessary for tissue homeostasis, which is preserved through the self-renewal and differentiation of somatic stem cells, as...
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Epigenetics of Lung Cancer
Lung cancer is the biggest cause of cancer-related death, with a 5-year survival rate of just 18%. Thanks to recent developments in targeted...
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The effect of DNA methylation on bumblebee colony development
BackgroundAlthough around 1% of cytosines in bees’ genomes are known to be methylated, less is known about methylation’s effect on bee behavior and...
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Evaluation of apoptosis stimulating protein of TP53-1 (ASPP1/PPP1R13B) to predict therapy resistance and overall survival in acute myeloid leukemia (AML)
ASPP1 ( PPP1R13B ) belongs to a family of p53-binding proteins and enhances apoptosis by stimulation of p53-transactivation of selected proapoptotic...
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Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization
Human intestinal peptide transporter PEPT1 is commonly repressed in human colorectal cancer (CRC), yet its relationship with sensitivity to the...
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The prognostic and therapeutic potential of HO-1 in leukemia and MDS
BackgroundHeme oxygenase-1 (HO-1), a heme-degrading enzyme, is proven to have anti-apoptotic effects in several malignancies. In addition, HO-1 is...
