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Detection and Interpretation of Cellular Structures in Tomograms: Segmentation, Localization and Spatial Pattern Analysis
A wealth of information is present in cellular cryo-ET images, from the shape of large three-dimensional cellular structures to structural details of...
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Differential cellular localization of DNA gyrase and topoisomerase IB in response to DNA damage in Deinococcus radiodurans
Topoisomerases are crucial enzymes in genome maintenance that modulate the topological changes during DNA metabolism. Deinococcus radiodurans , a...
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Validation of expression and cellular localization of AtZAT12 gene deleted an EAR motif in Nicotiana benthamiana using the transient expression system
Expression and cellular localization of recombinant proteins play a key role in identifying protein functions. Plant based transient expression was...
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LAMMER Kinase Governs the Expression and Cellular Localization of Gas2, a Key Regulator of Flocculation in Schizosaccharomyces pombe
It was reported that LAMMER kinase in Schizosaccharomyces pombe plays an important role in cation-dependent and galactose-specific flocculation....
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Expression and cellular localization of insulin-like growth factor 3 in gonads of the seasonal breeding teleost silver pomfret (Pampus argenteus)
Insulin-like growth factor 3 plays an important role in gonad development in teleost fish. Previous studies found that igf3 was specifically...
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Unified mRNA Subcellular Localization Predictor based on machine learning techniques
BackgroundThe mRNA subcellular localization bears substantial impact in the regulation of gene expression, cellular migration, and adaptation....
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Mechanistic insights into the basis of widespread RNA localization
The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested...
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Genetically encoded multimeric tags for subcellular protein localization in cryo-EM
Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of macromolecular assemblies in their native cellular context....
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Proteostasis, Proteodynamics and Cellular Aging
During each cell’s life, myriads of different, necessary proteins are manufactured and serve as interacting structural and/or functional elements...
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System-wide analysis of RNA and protein subcellular localization dynamics
Although the subcellular dynamics of RNA and proteins are key determinants of cell homeostasis, their characterization is still challenging. Here we...
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ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma
BackgroundAbnormal activation of FAK is associated with tumor development and metastasis. Through interactions with other intracellular signalling...
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MSLP: mRNA subcellular localization predictor based on machine learning techniques
BackgroundSubcellular localization of messenger RNA (mRNAs) plays a pivotal role in the regulation of gene expression, cell migration as well as in...
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Determination of CHK1 Cellular Localization by Immunofluorescence Microscopy
Many proteins involved in the DNA damage pathway shuttle between the cytoplasm and nucleus, and their localizations are important for functions. In...
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Sub-cellular localization of suppressor proteins of tomato leaf curl New Delhi virus
Tomato leaf curl New Delhi virus (ToLCNDV), a bipartite begomovirus, is the most important among the 14 species of begomoviruses infecting tomato in...
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Self-supervised deep learning encodes high-resolution features of protein subcellular localization
Explaining the diversity and complexity of protein localization is essential to fully understand cellular architecture. Here we present cytoself, a...
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Subcellular localization of fungal specialized metabolites
Fungal specialized metabolites play an important role in the environment and have impacted human health and survival significantly. These specialized...
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Proteomic Approach to Investigating Expression, Localization, and Functions of the SOWAHD Gene Protein Product during Granulocytic Differentiation
AbstractCataloging human proteins and evaluation of their expression, cellular localization, functions, and potential medical significance are...
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Cellular Blood Flow Modeling with HemoCell
Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and...
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Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of microtubules in neurons....
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Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis
Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close...
