Search
Search Results
-
Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease
Wilson’s disease (WD) is an inherited disorder characterized by excessive accumulation of copper in the body, particularly in the liver and brain. In...
-
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and particularly affects patients with obesity and type 2...
-
The Met1-linked ubiquitin machinery in inflammation and infection
Ubiquitination is an essential post-translational modification that regulates most cellular processes. The assembly of ubiquitin into polymeric...
-
A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury
As a common pathology of many ocular disorders such as diabetic retinopathy and glaucoma, retinal ischemia/reperfusion (IR) triggers inflammation and...
-
Bacterial cross talk with gut microbiome and its implications: a short review
Human gut microbiota exists in a complicated symbiotic relationship which postulates to impact health and disease conditions on the host....
-
Protein-Protein Interactions in Host–Pathogen Interactions
Human body is vulnerable to infection by several causative agents like viruses, bacteria, fungi, and protozoa. Currently, a lot of importance has...
-
Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet
Obesity, the cessation of ovarian steroids with menopause, and age are risk factors for mood disorders, dementia, and Alzheimer’s disease (AD)....
-
It's all relative: analyzing microbiome compositions, its significance, pathogenesis and microbiota derived biofilms: Challenges and opportunities for disease intervention
Concept of microorganisms has largely been perceived from their pathogenic view point. Nevertheless, it is being gradually revisited in terms of its...
-
Host genetic control of gut microbiome composition
The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is...
-
Beneficial Modulation of the Gut Microbiome: Probiotics and Prebiotics
The gut microbiota plays a critical role in the overall health of its host. Benefits derived from bacterial members of the gut microbiota can...
-
Citrobacter rodentium–host–microbiota interactions: immunity, bioenergetics and metabolism
Citrobacter rodentium is an extracellular enteric mouse-specific pathogen used to model infections with human pathogenic Escherichia coli and...
-
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10−/− model of colitis
Mutations in susceptibility alleles correlate with gut-inflammatory diseases, such as Crohn’s disease; however, this does not often impact the...
-
The role of the gut microbiome and its metabolites in metabolic diseases
It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has...
-
Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation
Kawasaki disease (KD) is the most common cause of pediatric cardiac disease in developed countries, and can lead to permanent coronary artery damage...
-
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon
Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural...
-
Bridging intestinal immunity and gut microbiota by metabolites
The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The...
-
Comprehensive review of ASC structure and function in immune homeostasis and disease
Apoptosis associated speck like protein containing CARD (ASC) is widely researched and recognized as an adaptor protein participating in inflammasome...
-
Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice
Inflammasomes are signalling platforms that are assembled in response to infection or sterile inflammation by cytosolic pattern recognition...
-
Evaluating the Correlations Between Osteoporosis and Lifestyle-Related Factors Using Transcriptome-Wide Association Study
Osteoporosis (OP) is a multi-factorial bone disease influenced by genetic factors, age, and lifestyles. The aim of this study is to evaluate the...
-
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular...
