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The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma
The introduction of the International Association for the Study of Lung Cancer grading system has furthered interest in histopathological grading for...
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Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis
Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found...
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A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2
The mitochondrial quality control of lung epithelial cells is disturbed during sepsis, which contributes to abnormal mitochondrial function and acute...
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Lung development and regeneration: newly defined cell types and progenitor status
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the...
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Stanniocalcin 1 promotes lung metastasis of breast cancer by enhancing EGFR–ERK–S100A4 signaling
Lung metastasis is the leading cause of breast cancer - related death. The tumor microenvironment contributes to the metastatic colonization of tumor...
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YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer
The Yes-associated protein (YAP) oncoprotein has been linked to both metastases and resistance to targeted therapy of lung cancer cells. We aimed to...
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ALK-positive lung cancer: a moving target
Anaplastic lymphoma kinase (ALK) is a potent oncogenic driver in lung cancer. ALK tyrosine kinase inhibitors yield significant benefit in patients...
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Challenges in Understanding the Lung Microbiota
The human lung has been less explored from the microbiological point of view because of the low concentration of microorganisms in this area,...
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CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation
Ovarian tumor family deubiquitinase 4 (OTUD4), a member of the OTU deubiquitinating enzyme, is implicated to decrease in cancer to regulate cell...
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Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors
AbstractLung cancer is one of the cancer types with the highest mortality worldwide. The most frequently mutated genes known to be clinically...
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Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy
BackgroundIn recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study,...
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Inhibition of ASAP1 Modulates the Tumor Immune Microenvironment and Suppresses Lung Cancer Metastasis via the p-STAT3 Signaling Pathway
ADP ribosylation factor guanylate kinase 1 (ASAP1), a key protein regulating cell migration and invasion, has attracted extensive attention in...
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YTHDC1 as a tumor progression suppressor through modulating FSP1-dependent ferroptosis suppression in lung cancer
Ferroptosis is a regulated cell death process initiated by iron-dependent phospholipid peroxidation and is mainly suppressed by GPX4-dependent and...
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Transcriptome profiling and metabolic pathway analysis towards reliable biomarker discovery in early-stage lung cancer
Earlier diagnosis of lung cancer is crucial for reducing mortality and morbidity in high-risk patients. Liquid biopsy is a critical technique for...
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Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation
ISGylation is a well-established antiviral mechanism, but its specific function in immune and tissue homeostasis regulation remains elusive. Here, we...
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An engineered influenza virus to deliver antigens for lung cancer vaccination
The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by challenges in delivery of...
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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into...
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HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1
Lung adenocarcinoma (LUAD) is a fatal threat to human health, while the mechanism remains unclear, and the therapy brings limited therapeutic...
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Polymicrobial Biofilms in Cystic Fibrosis Lung Infections: Effects on Antimicrobial Susceptibility
Chronic lung infection is the main cause of morbidity and mortality in people with cystic fibrosis (CF). For many years, it was thought that...
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Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a...
