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FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the...
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Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain...
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Advances in lymphatic metastasis of non-small cell lung cancer
Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis and treatment technology,...
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MicroRNA-3692-3p is overexpressed in lung tumors but may not serve as a prognostic biomarker in lung cancer patients
BackgroundWe previously reported overexpression of miR-3692-3p in the serum of non-small cell lung cancer patients. However, the expression profile...
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Integration of clinical phenoms and metabolomics facilitates precision medicine for lung cancer
Lung cancer is a common malignancy that is frequently associated with systemic metabolic disorders. Early detection is pivotal to survival...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and...
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Ornidazole Inhibits the Angiogenesis and Migration Abilities of Non-small Cell Lung
Background: Around the world, non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths among all cancers. Despite...
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Mechanisms of Bleomycin-induced Lung Fibrosis: A Review of Therapeutic Targets and Approaches
Pulmonary toxicity is a serious side effect of some specific anticancer drugs. Bleomycin is a well-known anticancer drug that triggers severe...
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Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwide. Lung cancer treatment...
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Crystal ribcage: a platform for probing real-time lung function at cellular resolution
Understanding the dynamic pathogenesis and treatment response in pulmonary diseases requires probing the lung at cellular resolution in real time....
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Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus
Social interactions affect physiological and pathological processes, yet their direct impact in peripheral tissues remains elusive. Recently we...
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Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis
Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found...
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Protective effect of apelin-13 on ventilator-induced acute lung injury
BackgroundMechanical Ventilation (MV) is an essential mechanism of life support in the clinic. It may also lead to ventilator-induced acute lung...
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ALK-positive lung cancer: a moving target
Anaplastic lymphoma kinase (ALK) is a potent oncogenic driver in lung cancer. ALK tyrosine kinase inhibitors yield significant benefit in patients...
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PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression
Lung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous...
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YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer
The Yes-associated protein (YAP) oncoprotein has been linked to both metastases and resistance to targeted therapy of lung cancer cells. We aimed to...
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Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice
Acute lung injury (ALI) poses a significant medical challenge due to its widespread occurrence and high mortality rates. Despite extensive efforts,...
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Cuproptosis in lung cancer: mechanisms and therapeutic potential
Cuproptosis, a recently identified form of cell death that differs from other forms, is induced by the disruption of the binding of copper to...
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Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain...
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Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders
IntroductionSepsis is a pathogenic syndrome of prolonged excessive inflammation and immunosuppression produced by invading pathogens. Programmed cell...
