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Behavioral Tagging: Unveiling the Intricacies of Memory Consolidation
Learning and memory are complex and interconnected processes that shape our understanding of the world. Learning involves the acquisition of new...
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Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating health disparities. We propose PolyPred, a method that...
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Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults
BackgroundPolymorphisms in ATP2B4 coding for PMCA4b, the primary regulator of erythrocyte calcium concentration, have been shown by GWAS and...
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Cross-ethnicity tagging SNPs for HLA alleles associated with adverse drug reaction
Reduction of adverse drug reaction (ADR) incidence through screening of predisposing human leucocyte antigen (HLA) alleles is a promising approach...
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Neurotrophins and Their Receptors Mediate Processes of Metaplasticity and Long-Term Memory Formation
In this chapter, a special class of small secretory peptides, the neurotrophins and their receptors, will be introduced as candidate molecules in...
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Metaplasticity and Synaptic Tag and Capture: Differential Dynamics of Plasticity Regulation in the Hippocampus
Synaptic plasticity is a critical underlying mechanism of learning and memory. There is extensive evidence that neural activity at one point in time...
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From Where? Synaptic Tagging Allows the Nucleus Not to Care
Most of us now accept that the formation of long-lasting memories requires the de novo transcription of plasticity-related proteins. It is also...
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Astrocytes: The Rising Stars that Regulate Synaptic Plasticity and Long-Term Memory Formation
For decades, our understanding of the mechanisms underlying long-term synaptic plasticity and memory is largely limited to the roles played by...
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Exploring New Horizons: Synaptic Tagging and Capture Beyond Space and Time
Synaptic tagging and capture (STC) encapsulates how synapses attain persistence in their plasticity through capturing newly synthesized...
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PKA Anchoring and Synaptic Tagging and Capture
Synaptic tagging and capture (STC) hypothesis has been receiving increasing attention because it reflects the heterosynaptic association of...
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Synaptic Tagging and Metaplasticity as Mediators of Neuronal Consciousness
Forming memories for highly arousing, novel, or salient events engages synaptic mechanisms that allow the association of temporally remote events and...
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Modeling tissue co-regulation estimates tissue-specific contributions to disease
Integrative analyses of genome-wide association studies and gene expression data have implicated many disease-critical tissues. However,...
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Synaptic Tagging and Capture: Functional Implications and Molecular Mechanisms
This chapter introduces the concept of synaptic tagging and capture, which was first identified in electrophysiological studies in hippocampal brain...
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Modeling Emergent Dynamics Arising from Synaptic Tagging and Capture at the Network Level
The transfer from short-term memory, which persists only for a few hours, to long-term memory is assumed to begin with a process called synaptic...
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Sentence Processing: How Words Generate Syntactic Structures in the Brain
Language comprehension relies on the fundamental ability to create meaningful syntactic structures from single words during on-line processing....
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Molecular Mechanisms Underlying Synaptic Tagging and Consolidation
After a synapse undergoes long-term potentiation (LTP), it acquires a newly remodeled molecular and structural organization. This reorganization over...
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Spatial Map: Through the Lens of Behavioral Tag and Capture
One of the fundamental attributes of memory is the synaptic plasticity change that happens at the cellular level and thereby behavioral change at the...
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High-dimensional multi-pass flow cytometry via spectrally encoded cellular barcoding
Advances in immunology, immuno-oncology, drug discovery and vaccine development demand improvements in the capabilities of flow cytometry to allow it...
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Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state...
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Effects of Shipping Noise on Migrating Ringed Seals
The emergence of ambient sound due to ship noise has adverse effects on pinnipeds. This chapter is focused on analyzing potential disturbance...
