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Muscular Dystrophy: Mutations in the Dystrophin Gene
Muscular dystrophy (MD) is a heterogeneous group of genetic disorders characterized by progressive muscle degeneration and weakness, leading to...
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Dissecting the Immune System through Gene Regulation
The immune system plays a dual role in human health, functioning both as a protector against pathogens and, at times, as a contributor to disease....
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Principles of Therapeutics and Gene-Based Therapy
This chapter focuses on the history and evolution of gene-based therapies from its inception in the early 1970s to the landmark discovery of the...
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Gene Therapy and Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading causes of death globally and urgently require new novel therapeutic strategies. Gene therapy is the...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...
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Decoding Dystrophin Gene Mutations: Unraveling the Mysteries of Muscular Dystrophy
Muscular dystrophies are a group of human monogenic disorders causing muscle weaknesses and affecting mobility. Mutations in different genes cause...
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Gene Therapy in Molecular Biology and Drug Delivery
The objective of gene therapy is to manipulate/modify the gene expression or modify living cell characteristics for therapeutic utilization. It aims...
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The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men
Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase ( MMP ) genes and their gene–gene and gene–environment...
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Immune Gene Therapy of Cancer
Cancer is the second global cause of mortality. Conventional treatments, such as chemotherapy and radiotherapy, have not provided desirable...
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Virus-Induced Heritable Gene Editing in Plants
Gene editing using clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) nuclease is an excellent tool for...
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Gene Delivery to Chondrocytes
Delivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the...
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Gene Editing in Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) can be isolated and collected from the body, genetically modified, and expanded ex vivo. The invention of innovative...
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Gene Therapy of Cancer Methods and Protocols
This third edition provides new and updated chapters on gene therapeutic strategies of cancer. Chapters guide readers through suicide and oncolytic...
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Assessment of the Gene Therapy Immune Response in the Canine Muscular Dystrophy Model
The immune response is a primary hurdle in the development of gene therapy for neuromuscular diseases. Both innate and adaptive immune responses have...
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Gene–Nutrient Interaction and Cancer Prevention
Research on carcinogenesis has provided a plethora of knowledge regarding cancer. Cancer cells are the product of numerous genetic abnormalities that...
