Search
Search Results
-
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids
Prenatal dexamethasone exposure (PDE) can decrease maternal endogenous glucocorticoid level and induce testicular dysplasia in male offspring rats....
-
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling
Both epidemiological and animal studies suggest that adverse environment during pregnancy can change the offspring development programming, but it is...
-
Maternal supplementation of alpha-lipoic acid ameliorates prenatal cytarabine-induced mutilation in reproductive development and function in F1 male adult rats
AimsCytarabine (CYT), a prevalent anticancer drug for blood cancers, detrimentally affects male reproductive development and function. Alpha-lipoic...
-
Prenatal detection and molecular cytogenetic characterization of Xp deletion and Xq duplication: a case report and literature review
BackgroundCopy number variation (CNV) of X chromosome can lead to a variety of neonatal abnormalities, especially for male fetuses. In recent years,...
-
Effects of Prenatal Stress on Reproductive Function in Male Rats
Glucocorticoid hormones suppress testosterone production by Leydig cells, by interacting with glucocorticoid receptors located in these...
-
Applying the adverse outcome pathway concept for assessing non-monotonic dose responses: biphasic effect of bis(2-ethylhexyl) phthalate (DEHP) on testosterone levels
Male reproduction is one of the primary health endpoints identified in rodent studies for some phthalates, such as DEHP (Bis(2-ethylhexyl)...
-
RETRACTED ARTICLE: Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesic agents. They have been detected in various environmental matrices. The...
-
Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics
Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as...
-
Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations
The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have...
-
Prenatal and Early Life Environmental Stressors: Chemical Moieties Responsible for the Development of Autism Spectrum Disorder
Autism spectrum disorder is a group of neurodevelopmental disorders, characterized by presence of repetitive behavior/interests and problems in...
-
Sex, hormones and cerebrovascular function: from development to disorder
Proper cerebrovascular development and neurogliovascular unit assembly are essential for brain growth and function throughout life, ensuring the...
-
Influence of pregnancy and non-fasting conditions on the plasma metabolome in a rat prenatal toxicity study
The current parameters for determining maternal toxicity (e.g. clinical signs, food consumption, body weight development) lack specificity and may...
-
Expanding the phenotype of copy number variations involving NR0B1 (DAX1)
46,XY gonadal dysgenesis (GD) is a disorder of sex development due to incomplete gonadal differentiation into testes, resulting in female to...
-
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats
BackgroundImidacloprid is a neonicotinoid insecticide belonging to the chloronicotinyl nitroguanidine chemical family. Toxicity of IMD for mammals in...
-
Neuroendocrinology of Human Cooperation and Parental Care
Human parental care appears to rely on the same neuroendocrine mechanisms that support parental care in other species, and other types of human...
-
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
To improve the mechanistic screening of reproductive toxicants in chemical-risk assessment and drug development, we have developed a...
-
The Level of Sex Hormones and Corticosterone in Female Rats during Modeling of Visceral Obesity, Subsequent Physical Activity, and Normalization of the Diet
The effects of diet-induced visceral obesity and non-drug options of its correction on the level of sex hormones and corticosterone were evaluated in...
-
Charles H. Phoenix
Charles H. Phoenix was a scientist whose most notable work investigated the role of sex steroidsSex steroids on the organizational role of the...
-
Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder of middle-aged to old individuals. The pathophysiological process of...
-
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus
BackgroundBisphenol A (BPA) has been linked to susceptibility to autism spectrum disorder (ASD). Our recent studies have shown that prenatal BPA...
