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The Placenta as a Neuroendocrine Organ
Pregnancy is a unique situation, in which two (or more) individuals are in intimate contact, with development of the foetus supported by a...
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Biased Expression of Parental Alleles in the Human Placenta
The biased expression of parental alleles plays a fundamental role in the formation of the placenta as a multifunctional organ necessary for the...
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Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
BackgroundExposure to environmental chemicals such as phthalates, phenols, and polycyclic aromatic hydrocarbons (PAHs) during pregnancy can increase...
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In Vitro Culturing of Human Trophoblasts from Term Placenta
Since the early 1960s, researchers began culturing placental cells to establish an in vitro model to study the biology of human trophoblasts,...
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Placenta-specific lncRNA 1600012P17Rik is expressed in spongiotrophoblast and glycogen trophoblast cells of mouse placenta
A few long noncoding RNAs (long ncRNAs, lncRNAs) exhibit trophoblast cell type-specific expression patterns and functional roles in mouse placenta....
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Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta
Plasma concentrations of N -arachidonyletholamine (AEA), N -oleoylethanolamide (OEA) and N -palmitoylethanolamide (PEA) increase at term and can predict...
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The anti-COVID-19 drug Paxlovid crosses biological barriers of the placenta and brain in rats
Paxlovid (nirmatrelvir plus ritonavir) is an orally available drug for the treatment of COVID-19 disease. However, limited information remains on the...
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Sex differences in early and term placenta are conserved in adult tissues
BackgroundPregnancy complications vary based on the fetus’s genetic sex, which may, in part, be modulated by the placenta. Furthermore, developmental...
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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis
Biologics have become increasingly prominent as therapeutics in recent years due to their innate immune-privileged nature, biocompatibility, and high...
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DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
BackgroundGestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. The placenta is a...
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Cross-Talk between Mucosal-Associated Invariant T, Natural Killer, and Natural Killer T Cell Populations is Implicated in the Pathogenesis of Placenta Accreta Spectrum
The study included 32 women with PAS and 20 with normally implanted placenta as a control group. Vascular endothelial cell growth factor (VEGF),...
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27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
Trophoblast cell syncytialization is essential for placental and fetal development. Abnormal trophoblast cell fusion leads to pregnancy pathologies,...
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Sex at the interface: the origin and impact of sex differences in the developing human placenta
The fetal placenta is a source of hormones and immune factors that play a vital role in maintaining pregnancy and facilitating fetal growth. Cells in...
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Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders
BackgroundPlacenta accreta spectrum disorders (PAS) are a severe complication characterized by abnormal trophoblast invasion into the myometrium. The...
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Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
Purpose of ReviewTo summarize recent literature relating early-life environmental exposures on DNA methylation in the placenta, to identify how...
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Placental Trophoblast Cell Isolation from the Term Placenta
Multiple cell lines have been utilized over time in studying placental biology. Still, most of them rely on choriocarcinoma cells or immortalized...
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Genes TMEM136 and PPP1R12C Differentially Expressed in the Placenta Are Associated with Preeclampsia
AbstractThe associations of genes differentially expressed in the placenta with the risk of preeclampsia in women in Central Russia were studied. The...
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Histological Study of the Features of Angiogenesis Lewis Lung Carcinoma under the Influence of Mesenchymal Stem Cells of the Placenta
Morphological features of angiogenesis processes in Lewis lung carcinoma (LLC) regrowth tumors were investigated and analyzed during their...
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Placenta on Chip: A Modern Approach to Probe Feto-Maternal Interface
The placenta is the primary link between the mother and the fetus. It regulates the exchange of nutrients, oxygen, and waste between the mother and...
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Possible transfer of lncRNA H19-derived miRNA miR-675-3p to adjacent H19-non-expressing trophoblast cells in near-term mouse placenta
LncRNA H19 serves as a regulatory RNA in mouse placental development. However, there is little information available on the in situ expression of H19 ...
