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Human Xenograft Model
Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric...
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Pig-to-human heart xenotransplantation in two recently deceased human recipients
Genetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for...
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Human Growth Hormone
Human growth hormone (hGH) is a protein hormone essential for normal growth and development in humans. In this chapter, the hGH structure, its...
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Human Cardiac Development
Many aspects of heart development are topographically complex and require three-dimensional (3D) reconstruction to understand the pertinent...
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Human Bocavirus
The Human Bocavirus (HBoV) was identified in Sweden over 10 years ago as a non-enveloped virus with linear ssDNA and was grouped under Parvoviridae....
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Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
BackgroundGenome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes....
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Gene Editing and Reprogramming of Human Fibroblast Cells to Human Induced Pluripotent Stem Cells
Predictive disease models play significant roles in advancing our knowledge of the pathology of human disease. In this field, animal models have been...
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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific...
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Duplex loop-mediated isothermal amplification assay for simultaneous detection of human and human male DNA
ObjectiveScreening of human and human male DNA is necessary for forensic DNA analyses. Although quantitative real-time PCR (qPCR) is commonly used...
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Effect of non-human hosts on the human biting rate of primary and secondary malaria vectors in Tanzania
BackgroundMalaria vectors vary in feeding preference depending on their innate behaviour, host availability and abundance. Host preference and human...
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Human Parasites Diagnosis, Treatment, Prevention
The new edition of this textbook provides an up-to-date overview of the most important parasites in humans and their potential vectors. Climate...
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Human Prion Disease Surveillance
Human prion diseases are characterized by rapid fatal neurodegeneration caused by pathologic prion proteins that are transmissible under specific...
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The Human Brainstem Anatomy and Pathology
The human brainstem has long been a neglected area in clinical medicine. This is shown by the fact that there is no introductory book on the...
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Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled humans to colonize diverse habitats, develop extraordinary...
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Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles
Both mesenchymal stromal cells (MSC) and induced pluripotent stem cells (iPSC) offer the potential for repair of damaged connective tissues. The use...
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Recombinant Human Deoxyribonuclease I
Human deoxyribonuclease I (DNase I) is an endonuclease that catalyzes the hydrolysis of extracellular DNA and is just one of the numerous types of...
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Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain largely elusive. Recently,...
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Generating Homogeneous Brain Organoids from Human iPSCs
There is a high demand for the development of in vitro models for human brain development and diseases due to the inaccessibility of human brain...
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Predicting Human Bioavailability of Subcutaneously Administered Monoclonal Antibodies Using Non-human Primate Linear Clearance and Antibody Isoelectric Point
The prediction of bioavailability is one of the major barriers in the clinical translation of subcutaneously (SC) administered therapeutic monoclonal...
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Human Genetics of Truncus Arteriosus
Integrated human genetics and molecular/developmental biology studies have revealed that truncus arteriosus is highly associated with 22q11.2...
