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Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions
Major Depressive Disorder (MDD) with childhood maltreatment is a prevalent clinical phenotype. Prior studies have observed abnormal hippocampal...
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Selective vulnerability of hippocampal sub-regions in patients with subcortical vascular mild cognitive impairment
Early diagnosis of subcortical vascular mild cognitive impairment (svMCI) is clinically essential because it is the most reversible subtype of all...
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TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
BackgroundNeonatal hypoxia ischemia (HI) related brain injury is one of the major causes of learning disabilities and memory deficits in children. In...
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Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function....
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Hippocampal Malrotation: Is It Epileptogenic?
Hippocampal malrotation (HIMAL) is an anatomical phenomenon appearing as incomplete rotation of the hippocampus in the course of ontogenesis. The...
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Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous...
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Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion
Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the...
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Transient global amnesia and hippocampal diffusion restriction: an overlooked radiological finding
Transient global amnesia (TGA) is characterized by isolated sudden anterograde amnesia. Diffusion restriction can be observed in the hippocampus on...
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Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease
BackgroundAdult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal...
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The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Aluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer’s disease (AD). We uesd a...
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Deferoxamine Mitigates Ferroptosis and Inflammation in Hippocampal Neurons After Subarachnoid Hemorrhage by Activating the Nrf2/TXNRD1 Axis
Ferroptosis is a distinct peroxidation-driven form of cell death tightly involved in subarachnoid hemorrhage (SAH). This study delved into the...
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Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice
Exercise can induce beneficial improvements in cognition. However, the effects of different modes and intensities of exercise have yet to be explored...
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Neurochemistry of the mammillary body
The mammillary body (MB) is a component of the extended hippocampal system and many studies have shown that its functions are vital for mnemonic...
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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy....
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CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model
Status epilepticus (SE), the most severe form of epilepsy, leads to brain damage. Uncertainty persists about the mechanisms that lead to the...
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Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection
Combination antiretroviral therapy (cART) has extended lifespans of people living with HIV (PWH), increasing both the risk for age-related...
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RETRACTED ARTICLE: Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesic agents. They have been detected in various environmental matrices. The...
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Hippocampal subfield volumes in mild cognitive impairment and alzheimer’s disease: a systematic review and meta-analysis
The hippocampus is a complex structure that consists of several subfields with distinct and specialized functions. Although numerous studies have...
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Hippocampal representations of foraging trajectories depend upon spatial context
Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of...
