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Introduction to Yeast and Fungal Prions
“Prion” now means “infectious protein,” not requiring an accompanying nucleic acid for transmission to a new individual. In 1994, we found that the...
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Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins
Yeast, fungal, and mammalian prions determine heritable as well as infectious traits (Shorter J, Lindquist S. Nat Rev Genet, 6:435–450, 2005; Wickner...
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Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems
Most yeast prions are self-propagating amyloids of normally non-amyloid proteins. The prion domains of Ure2p, Sup35p, and Rnq1p each form highly...
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Modeling the Cell Biology of Prions
Cell models have been useful for elucidating the function of proteins and/or their role in pathogenesis. Even before the discovery that the prion...
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Slow Virus and Prion Diseases
Slow virus diseases are a large group of related neurodegenerative conditions which affect both humans and animals. The diseases are caused by a...
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Therapeutic development of polymers for prion disease
Prion diseases, also known as transmissible spongiform encephalopathies, are caused by the accumulation of abnormal isoforms of the prion protein...
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Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
BackgroundRecent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the...
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Viruses
Viruses are noncellular, obligate intracellular parasites that infect all types of cellular organisms. Some cause severe diseases in humans and...
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Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease
Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional...
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Prion disease modelled in Drosophila
Prion diseases are fatal neurodegenerative conditions of humans and various vertebrate species that are transmissible between individuals of the same...
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Researcher perspectives on ethics considerations in epigenetics: an international survey
Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigenetic...
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Analysis of miRNA expression profiles in exosomes of SMB-S15 cells treated with resveratrol
Exosomes are double-layered vesicle bodies secreted by cells, in which microRNAs (miRNAs) play an important role. In a previous study, we found that...
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Expanding the Landscape of Amyloid Sequences with CARs-DB: A Database of Polar Amyloidogenic Peptides from Disordered Proteins
Several databases collecting amyloidogenic regions have been released to provide information on protein sequences able to form amyloid fibrils....
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Exosomal MicroRNAs as Brain Memory Devices
MicroRNAs (miRNAs) have been implicated in brain memory mechanisms. miR-9c, miR-31a, miR-305, miR-974, and miR-980 were involved in memory formation...
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Drosophila Models of Prion Diseases
Prion diseases encompass a heterogeneous group of fatal brain disorders associated with the accumulation of misfolded isoforms of the prion protein...
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The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis
AbstractThe progression of prion diseases is accompanied by the accumulation of prions in the brain. Ablation of microglia enhances prion...
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Stem Cell Models in Prion Research
Stem cells have the capacity to differentiate into the mature cells of any organ within the body. For this reason, they offer an interesting...
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Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability
Prion protein (PrP) adopts either a helical conformation (PrP C ) or an alternative, beta sheet-rich, misfolded conformation (PrP Sc ). The PrP Sc form...
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Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases
Prion disease is a diverse family of fatal and usually transmissible and progressive neurodegenerative diseases that strike humans and many other...
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NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling
Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. Here, we identify a...
