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Cell–Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics
Henipaviruses include the deadly zoonotic Nipah (NiV) and Hendra (HeV) paramyxoviruses, which have caused recurring outbreaks in human populations. A...
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Equid herpesvirus type 3 infection produces membrane-associated and secreted forms of glycoprotein G that are not required for efficient cell-to-cell spread of the virus in vitro
The ORF 70 gene of equid alphaherpesvirus type 3 (EHV-3) encodes glycoprotein G (gG), which is conserved in the majority of alphaherpesviruses. This...
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Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease
Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous...
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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the...
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Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs) have emerged as an innovative model to study the central...
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Use of Antibiotics to Eliminate Wolbachia from Mosquitoes and Cell Culture
Removal of Wolbachia from infected insects is required in most experimental settings when the effects of Wolbachia on biological traits, pathogen...
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An Overview of the Cell Biology and Genetic Barriers to Virus Infections with Implications in Cell Line Development for Virotherapy
Viruses can be engineered for oncolysis, gene therapy, or vaccines. Oncolytic viruses and viral vector for cell and gene therapies are promising...
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Immune checkpoint inhibitor (ICI) therapy has revolutionized oncology, but treatments are limited by immune-related adverse events, including...
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Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease with high pulmonary arterial pressure, pulmonary vasoconstriction, pulmonary vascular remodeling, and...
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Resistance to BRAF inhibition explored through single circulating tumour cell molecular profiling in BRAF-mutant non-small-cell lung cancer
BackgroundResistance mechanisms to combination therapy with dabrafenib plus trametinib remain poorly understood in patients with BRAF V600E -mutant...
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Reducing and controlling metabolic active tumor volume prior to CAR T-cell infusion can improve survival outcomes in patients with large B-cell lymphoma
Bridging therapy before CD19-directed chimeric antigen receptor (CAR) T-cell infusion is frequently applied in patients with relapsed or refractory...
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Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the...
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Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have previously demonstrated that human...
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Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to activate large numbers of T cells simultaneously. SAgs...
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Inflammatory response-based prognostication and personalized therapy decisions in clear cell renal cell cancer to aid precision oncology
ObjectiveThe impact of inflammatory response on tumor development and therapeutic response is of significant importance in clear cell renal cell...
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Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity
Cell’s shape is dependent on the cytoskeleton mechanical properties. Hybrid models were developed that combine the discrete structure for the...
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Characterization of B-cell and T-cell responses to a tetravalent dengue purified inactivated vaccine in healthy adults
The increasing global impact of dengue underscores the need for a dengue virus (DENV) vaccine. We assessed B-cell and T-cell responses following...
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Electrical cell-substrate impedance sensing (ECIS) as a tool to study microbial-cell interactions
ECIS is an impedance-based method to study the cellular responses to a stimulus. Manipulating the alternating current frequencies in ECIS helped...
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Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape
BackgroundIntratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and...
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SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting in a global pandemic. While...
