Abstract
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs, mitochondria rapidly modulate their physiological processes to maintain cellular homeostasis. Rapid changes in mitochondrial network are found to be intricately related to cellular health and disease conditions. Due to its high energy demand, neuron activity largely depends on mitochondrial function. Recent evidence demonstrates a link between mitochondrial dynamics and the pathophysiology of various neurological disorders. In this review, we will discuss how the protein interaction networks controlling mitochondrial fission/fusion could be a promising drug target for neurodegenerative diseases.
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Data availability
No datasets were generated or analysed during the current study.
References
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S.M. acknowledges DST for SERB-Start-Up-Research Grant (SRG/2022/001921), ICMR for Ad-hoc research grant (Project ID 2021-13896), and BITS-Pilani (Hyderabad Campus) for OPERA fellowship. V.K. acknowledge BITs-Pilani (Hyderabad Campus) for Institutional doctoral fellowship. P.K acknowledge CSIR/UGC/NFOBC for doctoral fellowship.
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V.K., P.K., and S.M. contributed to the literature search, writing the original draft of the review. S.M. conceptualized and supervised for the overall completion. All authors have read and agreed to the published version of the manuscript.
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Kumar, V., Kodam, P. & Maity, S. Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases. J Proteins Proteom (2024). https://doi.org/10.1007/s42485-024-00155-7
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DOI: https://doi.org/10.1007/s42485-024-00155-7