... of the AVP gene. Furthermore, we found sex-specific changes in mean methylation levels of the mentioned genes throughout smoking cessation, underlining the relevance of sex in the OT and vasopressin system. This is the first study on epigenetic regulation of the OT promoter in TUD. Our results have...

... summarize current knowledge about the genetic and epigenetic regulation of enzymes involved in melatonin synthesis and metabolism as potential features of depression pathophysiology and treatment. Confirmation that melatonin metabolism in peripheral blood partially reflects a disorder in the brain could...

... that the combined analysis of CpG SNPs and methylation may be useful for investigating the genetic and epigenetic factors involved in suicidal behavior. Despite previous investigations examining the expression and polymorphisms of 5-HT receptors in suicide, little is known about the relationship between...

...Tadafumi Kato It is not known whether and how epigenetic factors contribute to the pathophysiology of mental disorders. As possible mechanisms, epimutations during embryogenesis, epigenetic memory of environmental effects, and the role of epigenetic gene regulation in the action mechanisms...