... with AUD, in vivo dopamine D2 and D3 receptor availability appears to be reduced, which may be a predisposing factor or the result of a neuroadaptive process influencing drug-induced DA release. DA transporter availability is reduced in AUD, whereas findings with respect to DA synthesis capacity...

... pathology, but sex-related neurodevelopment has not been fully investigated in this model. We conducted this study to facilitate the understanding of the pathophysiology of neurodevelopmental disorders. Methods: Pregnant rats received 50 mg/kg BrdU on gestational days 9–15. The tissue content of dopamine...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Dopamine Gene DRD2 gene ANKK1 gene Suicide Suicide represents a significant health problem that has a global...

... to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h...

... basis underlying individual differences in social conformity. A recent study demonstrated an association between enhanced dopaminergic function and increased conforming behavior. Given the effect of the dopamine receptor 3 gene (DRD3) Ser9Gly polymorphism (rs6280) on dopamine release in the striatum...

...' and ‘liking', in dependence of the dopamine-related Taq1A genotype (ANKK1/DRD2). Research suggests that ‘wanting' as opposed to ‘liking' is related to dopaminergic processes. Therefore, it was hypothesized that risk allele carriers of the Taq1A polymorphism exhibit late ERP changes in reaction to words...

... Dopamine Homovanillic acid Treatment responsiveness Psychosis spectrum disorders, particularly schizophrenia, have been linked to dysregulated dopamine (DA) neurotransmission in the central nervous system. It has been demonstrated that DA hyperactivity in subcortical areas results in positive...

..., it is worthy of note that oxytocin interacts with the dopaminergic system [ 4,9 ]. Oxytocin neurons express dopamine receptors in the hypothalamus [ 10 ], while the dopamine and oxytocin pathways converge in the frontal cortex, ventral striatum and ventral tegmental areas [ 11,12 ]. It is well known...

... Reinforcement learning Dopamine Computational psychiatry Substance dependence is characterized by maladaptive choices that contrast with the subjects' explicitly stated desires, such as the failure to abstain despite the desire to quit drinking. This inflexible and compulsive behavior in addiction...

... to the complexity of dopaminergic neurotransmission in the two distinct prosencephalic dopamine pathways, we examined whether the effects of dopamine-related candidate polymorphisms in the genes DRD2, SLC6A3, COMT and MAOA may be differentially associated with discrete subcomponents of RTV, rather than global RTV...

... with high dopamine availability. The Hardy-Weinberg equilibrium was analyzed with a web tool by Rodriguez et al. [ 24 ]. The allele frequencies for the variable number of AP-2β [CAAA] sequences were 38.5% (n = 154) for 4 × [CAAA] and 61.3% (n = 245) for 5 × [CAAA], and there was 1 rare variation...

..., ICF) in the human brain [ 13 ]. SICI is discussed to be mediated by GABAergic interneurons via GABA A receptors and ICF might result from primarily glutamatergic neurotransmission [ 14 ]. Furthermore, dopaminergic neurotransmission has an impact on SICI and ICF, because dopamine agonists lead...

...Anne Pankow; Astrid Knobel; Martin Voss; Andreas Heinz Dopamine dysfunction is a mainstay of theories aimed to explain the neurobiological correlates of schizophrenia symptoms, particularly positive symptoms such as delusions and passivity phenomena. Based on studies revealing dopamine dysfunction...

...Bi Zhu; Chuansheng Chen; Robert K. Moyzis; Qi Dong; Chunhui Chen; Qinghua He; Hal S. Stern; He Li; Jin Li; Jun Li; Jared Lessard; Chongde Lin Objective: This study investigated the relation between genetic variations in the dopamine system and facial expression recognition. Methods: A sample...

...Sara Landgren; Kristina Berglund; Elisabet Jerlhag; Claudia Fahlke; Jan Balldin; Ulf Berggren; Henrik Zetterberg; Kaj Blennow; Jörgen A. Engel Components of the brain reward system, i.e. the mesolimbic dopamine, laterodorsal cholinergic and ghrelin signaling systems, have been implicated in alcohol...

... and after dexamethasone) and monoamine activity (24-hour urinary excretion of norepinephrine, serotonin, dopamine, and their main metabolites: 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid). Furthermore, the relationships between the 2 sets of variables were compared...

...Claudia Martini; Simona Daniele; Michela Picchetti; Anna Panighini; Marina Carlini; Maria Letizia Trincavelli; Daniela Cesari; Eleonora Da Pozzo; Francesca Golia; Liliana Dell’Osso Background/Aims: A structural and functional interaction between A 2A adenosine receptors and D 2 dopamine receptors...

...Jee In Kang; Se Joo Kim; Kee Namkoong; Suk Kyoon An Background: Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4...

... species (ROS) in the mechanisms underlying MDMA toxicity, the source of free radicals is still a matter of debate. While some authors support dopamine metabolism/oxidation inside 5-hydroxytryptamine (5-HT) terminals as the key factor responsible for ROS formation and final 5-HT terminal degeneration...

... groups. Neurochemical analysis using high-performance liquid chromatography revealed few lasting changes in serotonin, dopamine or their metabolites in the striatum or prefrontal cortex of MDMA- or GHB-pre-exposed rats. These results indicate that GHB modulates the locomotor and hyperthermic response...