Dedicated/small RGS |
RGS1 | 196h | Short N-terminal domain, function not determined | Lymphocytes | Down-regulates chemotaxis of lymphocytes to chemokines (Moratz et al., 2000)1-b; modulates postsynaptic GIRK currents in neurons and atrial cells (Doupnik et al., 1997) |
RGS2 | 211h | | Ubiquitous | Suppresses mGluR1a-mediated inhibition of M-type potassium currents in sympathetic neurons (Kammermeier and Ikeda, 1999); inhibits muscarinic acetylcholine receptor-mediated MAP kinase activation (Ingi et al., 1998). Knockout mice show reduced T cell proliferation and IL-2 production, increased anxiety responses, and decreased male aggression (Oliveira-Dos-Santos et al., 2000). Functions are also implied by its dynamic regulation in osteoblasts as well as by its increase in expression in response to stimuli such as elevated cAMP levels, PKC, neuronal activity, and certain psychoactive agents (Ingi et al., 1998; Burchett et al., 1999). |
RGS8 | 180r | | Brain | Accelerates GIRK currents (Saitoh et al., 1999); attenuate receptor-mediated Ca2+ channel inhibition in HEK293 cells1-b
|
RGS10 | 173h | | Brain |
RGS13 | 159h | | Lung |
RGS18 | 235m | | Bone marrow1-150 lung, spleen, fetal liver | Attenuates angiotensin receptor-mediated IP production and M1 muscarinic receptor-stimulated gene activation via cAMP-responsive element (Park et al., 2000) |
RGS4 | 205r | Short N-terminal domain with amphipathic helices important for membrane association | Brain, heart | Down-regulates chemotaxis of lymphocytes to chemokines1-b; modulates GIRK currents in neurons and atrial cells (Doupnik et al., 1997); inhibits translocation of the glucose transporter (Glut4) in adipocytes (Kanzaki et al., 2000) |
RGS5 | 181m | | Brain, heart, lung, muscle |
RGS161-c
| 201m | | Liver, pituitary | Attenuates platelet-activating factor-induced responses in CHO cells1-b; inhibits translocation of Glut4 in adipocytes (Kanzaki et al., 2000); potential function is suggested by increased expression of RGS16 in response to genotoxic stress (Buckbinder et al., 1997) and by its possible mutation contributive to certain forms of retinitis pigmentosa (Bessant et al., 2000) |
Dedicated RGS? |
RGS3 | 519h | Long N-terminal domain, function not determined | Kidney | Down-regulates chemotaxis of lymphocytes to chemokines1-b; modulates postsynaptic GIRK currents in neurons and atrial cells (Doupnik et al., 1997); reduces tubular migration in kidney (Gruning et al., 1999); attenuates receptor-mediated Ca2+ channel inhibition in HEK293 cells1-b
|
C29H12.3 | 284e | (2 RGS domains) |
DEP/GGL RGS |
RGS6 | 567h | N-terminal DEP/GGL | Brain |
RGS7 | 469h | | Brain (neocortex1-150, hippocampus1-150, and certain nuclei1-150) | Up-regulation of RGS7 suggests a role in tumor necrosis factor-induced changes in the brain (Benzing et al., 1999); interacts with polycystin (Kim et al., 1999) |
RGS9-1 | 484h | | Retina | Accelerates recovery of rod vision (Chen et al., 2000) |
RGS9-2 | 674h | | Brain (especially striatum1-150) | Decreases Gi/o coupled μ-opioid receptor response in vitro (Rahman et al., 1999) |
RGS11 | 467h | | Brain |
EGL-10 | 555e | | | Regulates egg-laying behavior (Koelle and Horvitz, 1996) |
EGL-16 | 474e | | | Inhibits endogenous Gq/G11 activity in COS-7 cells (Hajdu-Cronin et al., 1999) |
Cysteine string RGS |
GAIP | 217h | N-terminal cysteine string | Heart, liver, lung | Possible role in the regulation of vesicular trafficking (De Vries et al., 1998) |
Ret-RGS1 | 374b | | Retina |
RGS-Z1 | 217h | | Brain |
RGS171-d
| 210c | | Not determined |
GoLoco RGS |
RGS12 | 1387r | Raf-I; GoLoco; PDZ/PTB | Brain, lung, liver | Inhibits Gα12/Gα13-mediated serum response factor activation in NIH3T3 cells1-b
|
RGS14 | 547m | Raf-I, GoLoco | Brain, lung, spleen | Attenuates IL-8 receptor-mediated MAP kinase activation and M1 acetylcholine receptor-stimulated c-fos SRE activation (Cho et al., 2000) |
Axin RGS |
Axin | 832r | GSK-β3/β-catenin binding; DIX | Ubiquitous | Generally viewed as a tumor suppressor (Peifer and Polakis, 2000) |
Conductin | 840m | | Brain, liver, lung |
RhoGEF RGS |
P115RhoGEF | 913h | DH/PH | Ubiquitous |
LscRhoGEF | 914m | DH/PH | Ubiquitous |
PDZRhoGEF | 1522h | DH/PH; PDZ | Ubiquitous |
GRK RGS |
GRK21-e
| 689h | Kinase/GRK; Gβγ binding | Brain | Inhibits Gα-mediated activation of PLC in HEK293 cells (Carman et al., 1999) |
GRK31-e
| 688h | | Brain |
RasGAP RGS |
Sst2 | 698y | RasGAP | | Inhibits pheromone response (Dohlman et al., 1996) |
FLBA | 719y |
AKAP RGS |
D-AKAP2 | 372m | PKA anchoring | Ubiquitous |