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Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

Author

Listed:
  • Shan H. Siddiqi

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Frederic L. W. V. J. Schaper

    (Brigham and Women’s Hospital
    Harvard Medical School
    Maastricht University Medical Center)

  • Andreas Horn

    (Brigham and Women’s Hospital
    Harvard Medical School
    Charité University Medicine Berlin)

  • Joey Hsu

    (University of Pittsburgh School of Medicine)

  • Jaya L. Padmanabhan

    (Brigham and Women’s Hospital)

  • Amy Brodtmann

    (The University of Melbourne)

  • Robin F. H. Cash

    (The University of Melbourne
    The University of Melbourne)

  • Maurizio Corbetta

    (University of Padova
    Washington University)

  • Ki Sueng Choi

    (Icahn School of Medicine at Mount Sinai)

  • Darin D. Dougherty

    (Harvard Medical School
    Massachusetts General Hospital)

  • Natalia Egorova

    (University of Melbourne
    The Florey Institute of Neuroscience and Mental Health)

  • Paul B. Fitzgerald

    (Epworth Healthcare and Monash University Department of Psychiatry)

  • Mark S. George

    (Medical University of South Carolina
    Ralph H. Johnson VA Medical Center)

  • Sophia A. Gozzi

    (Monash University)

  • Frederike Irmen

    (Humboldt-Universität zu Berlin and Berlin Institute of Health)

  • Andrea A. Kuhn

    (Charité University Medicine Berlin)

  • Kevin A. Johnson

    (Florida State University)

  • Andrew M. Naidech

    (Northwestern University)

  • Alvaro Pascual-Leone

    (Harvard Medical School
    Hebrew SeniorLife
    Universitat Autonoma)

  • Thanh G. Phan

    (Monash University)

  • Rob P. W. Rouhl

    (Maastricht University Medical Center
    Maastricht University
    Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center)

  • Stephan F. Taylor

    (University of Michigan School of Medicine)

  • Joel L. Voss

    (Northwestern University)

  • Andrew Zalesky

    (The University of Melbourne
    The University of Melbourne)

  • Jordan H. Grafman

    (Northwestern University
    Shirley Ryan AbilityLab)

  • Helen S. Mayberg

    (Icahn School of Medicine at Mount Sinai)

  • Michael D. Fox

    (Brigham and Women’s Hospital
    Harvard Medical School)

Abstract

Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep brain stimulation (n = 101, five datasets). Lesions and stimulation sites most associated with depression severity were connected to a similar brain circuit across all 14 datasets (P

Suggested Citation

  • Shan H. Siddiqi & Frederic L. W. V. J. Schaper & Andreas Horn & Joey Hsu & Jaya L. Padmanabhan & Amy Brodtmann & Robin F. H. Cash & Maurizio Corbetta & Ki Sueng Choi & Darin D. Dougherty & Natalia Ego, 2021. "Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease," Nature Human Behaviour, Nature, vol. 5(12), pages 1707-1716, December.
    • Handle: RePEc:nat:nathum:v:5:y:2021:i:12:d:10.1038_s41562-021-01161-1
    DOI: 10.1038/s41562-021-01161-1

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