Online First

July 05, 2024

Letter
Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms

Xiangsheng Zuo, Liang Wang, Yi Liu, Huamin Wang, Margarete Hafley, Mihai Gagea, Ru Chen, Yun Xiong, Sheng Pan, Imad Shureiqi, Robert S Bresalier, Daoyan Wei

doi: 10.1136/gutjnl-2024-332255
Letter
Human CAZyme genes polymorphism and risk of IBS: a population-based study

Leire Torices, Andreea Zamfir-Taranu, Cristina Esteban-Blanco, Isotta Bozzarelli, Ferdinando Bonfiglio, Mauro D'Amato

doi: 10.1136/gutjnl-2024-333056
Stomach
KLHL21 suppresses gastric tumourigenesis via maintaining STAT3 signalling equilibrium in stomach homoeostasis

Xiao-Bo Huang, Qiang Huang, Mei-Chen Jiang, Qing Zhong, Hua-Long Zheng, Jia-Bin Wang, Ze-Ning Huang, Hua-Gen Wang, Zhi-Yu Liu, Yi-Fan Li, Kai-Xiang Xu, Mi Lin, Ping Li, Zhi-Hong Huang, Jian Wei Xie, Jian-Xian Lin, Jun Lu, Jian-Wen Que, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang

doi: 10.1136/gutjnl-2023-331111
Commentary
Immunomodulation and entry inhibition: selgantolimod’s double punch against hepatitis B virus

Thomas Baumert, Melanie Urbanek-Quaing, Markus Cornberg

doi: 10.1136/gutjnl-2024-332679
Commentary
When alcohol and fat meet, neutrophil traps form to promote liver injury

Gavin E Arteel, Bin Gao

doi: 10.1136/gutjnl-2024-332514

July 04, 2024

Endoscopy
Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial

Timothy O��Sullivan, Oliver Cronin, W Arnout van Hattem, Francesco Vito Mandarino, Julia L Gauci, Clarence Kerrison, Anthony Whitfield, Sunil Gupta, Eric Lee, Stephen J Williams, Nicholas Burgess, Michael J Bourke

doi: 10.1136/gutjnl-2024-332807

July 03, 2024

Gut microbiota
Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms

Haitao Sun, Kaijian Sun, Hao Tian, Xiheng Chen, Shixing Su, Yi Tu, Shilan Chen, Jiaxuan Wang, Meichang Peng, Meiqin Zeng, Xin Li, Yunhao Luo, Yugu Xie, Xin Feng, Zhuang Li, Xin Zhang, Xifeng Li, Yanchao Liu, Wei Ye, Zhengrui Chen, Zhaohua Zhu, Youxiang Li, Fangbo Xia, Hongwei Zhou, Chuanzhi Duan

doi: 10.1136/gutjnl-2024-332245

July 02, 2024

Letter
Porcine-derived pancreatic enzyme replacement therapy: a cause of hepatitis E virus transmission?

Nassim Kamar, Olivier Marion, Florence Abravanel, Laure Esposito, Arnaud Del Bello, Jacques Izopet

doi: 10.1136/gutjnl-2024-332744
Gut microbiota
Multiple indicators of gut dysbiosis predict all-cause and cause-specific mortality in solid organ transplant recipients
Free

J Casper Swarte, Shuyan Zhang, Lianne M Nieuwenhuis, Ranko Gacesa, Tim J Knobbe, TransplantLines Investigators, Vincent E De Meijer, Kevin Damman, Erik A M Verschuuren, Tji C Gan, Jingyuan Fu, Alexandra Zhernakova, Hermie J M Harmsen, Hans Blokzijl, Stephan J L Bakker, Johannes R Björk, Rinse K Weersma

doi: 10.1136/gutjnl-2023-331441

July 01, 2024

Pancreas
Pancreatic STAT5 activation promotes Kras^G12D-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer

Yuli Lin, Shaofeng Pu, Jun Wang, Yaqi Wan, Zhihao Wu, Yangyang Guo, Wenxue Feng, Ying Ying, Shuai Ma, Xiang Jun Meng, Wenquan Wang, Liang Liu, Qing Xia, Xuguang Yang

doi: 10.1136/gutjnl-2024-332225

June 29, 2024

Recent advances in basic science
Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinoma

Suki Ha, Vincent Wai-Sun Wong, Xiang Zhang, Jun Yu

doi: 10.1136/gutjnl-2024-332398

June 27, 2024

Letter
Long-term stability of the faecal microbiome profile in faecal immunochemical test (FIT) samples

Suparna Mitra, Christopher J Stewart, Andrew Nelson, James S Hampton, Andrea C Masi, Sarah Manning, Linda Sharp, Mark A Hull, Colin J Rees

doi: 10.1136/gutjnl-2024-332584
Hepatology
High accuracy model for HBsAg loss based on longitudinal trajectories of serum qHBsAg throughout long-term antiviral therapy

Rong Fan, Siru Zhao, Junqi Niu, Hong Ma, Qing Xie, Song Yang, Jianping Xie, Xiaoguang Dou, Jia Shang, Huiying Rao, Qi Xia, Yali Liu, Yongfeng Yang, Hongbo Gao, Aimin Sun, Xieer Liang, Xueru Yin, Yongfang Jiang, Yanyan Yu, Jian Sun, Nikolai V Naoumov, Jinlin Hou Chronic Hepatitis B Study Consortium

doi: 10.1136/gutjnl-2024-332182

June 26, 2024

Probiotics
Gut microbiota signatures of vulnerability to food addiction in mice and humans

Solveiga Samulėnaitė, Alejandra García-Blanco, Jordi Mayneris-Perxachs, Laura Domingo-Rodríguez, Judit Cabana-Domínguez, Noèlia Fernàndez-Castillo, Edurne Gago-García, Laura Pineda-Cirera, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Koji Hosomi, Jun Kunisawa, Bru Cormand, Jose Manuel Fernández-Real, Rafael Maldonado, Elena Martín-García

doi: 10.1136/gutjnl-2023-331445

June 21, 2024

Helicobacter pylori
Simplified Helicobacter pylori therapy for patients with penicillin allergy: a randomised controlled trial of vonoprazan-tetracycline dual therapy

Wen Gao, Jianxiang Liu, Xiaolei Wang, Jingwen Li, Xuezhi Zhang, Hui Ye, Jiang Li, Xinhong Dong, Binbin Liu, Chi Wang, Ying Xu, Guigen Teng, Yuling Tian, Jinpei Dong, Chaoyi Ge, Hong Cheng

doi: 10.1136/gutjnl-2024-332640

June 19, 2024

Commentary
Presenilins: the hidden guardians of gut health in Alzheimer’s disease

Julian Schwärzler, Bram Verstockt

doi: 10.1136/gutjnl-2024-332677
Commentary
Blautia: a key moderator of compulsivity towards chocolate?

Alice de Wouters d'Oplinter

doi: 10.1136/gutjnl-2024-332568
Commentary
Diagnostic upper GI endoscopy: can less mean more?

Ian Penman

doi: 10.1136/gutjnl-2024-332680

June 18, 2024

Letter
Familial pancreatitis associated with a splice-site variant in CPA1

Fang Shen, Hongmei Zhao, Mei Deng, Ming Tu, Yuan Hu, Hua Wang, Yongjia Yang

doi: 10.1136/gutjnl-2024-332845
Letter
Association between appendectomy and Parkinson’s disease from the UK Biobank

Zhiyun Wang, Mengjie LI, Dongrui Ma, Mengnan Guo, Xiaoyan Hao, Zhengwei Hu, Shuangjie Li, Chunyan Zuo, Yuanyuan Liang, Chenwei Hao, Yanmei Feng, Chan Zhang, Chengyuan Mao, Jun Wu, Shilei Sun, Yu-Ming Xu, Changhe Shi

doi: 10.1136/gutjnl-2024-332353
Commentary
Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment

Jun Sun

doi: 10.1136/gutjnl-2024-332560

June 17, 2024

Recent advances in basic science
Stomach microbiota in gastric cancer development and clinical implications

Ruijie Zeng, Hongyan Gou, Harry Cheuk Hay Lau, Jun Yu

doi: 10.1136/gutjnl-2024-332815

June 14, 2024

Endoscopy
Clinical consequences of computer-aided colorectal polyp detection

Pieter Sinonquel, Tom Eelbode, Oliver Pech, Dominiek De Wulf, Pieter Dewint, Helmut Neumann, Giulio Antonelli, Federico Iacopini, David Tate, Arnaud Lemmers, Nastazja Dagny Pilonis, Michal Filip Kaminski, Philip Roelandt, Cesare Hassan, Demedts Ingrid, Frederik Maes, Raf Bisschops

doi: 10.1136/gutjnl-2024-331943
Letter
Porcine-derived pancreatic enzyme replacement therapy linking to chronic hepatitis E: broad implications

Jiahua Zhou, Kuan Liu, Qiuwei Pan

doi: 10.1136/gutjnl-2024-332975
Intestinal inflammation
Protective function of sclerosing cholangitis on IBD

Tanja Bedke, Friederike Stumme, Miriam Tomczak, Babett Steglich, Rongrong Jia, Simon Bohmann, Agnes Wittek, Jan Kempski, Emilia Göke, Marius Böttcher, Dominik Reher, Anissa Franke, Maximilian Lennartz, Till Clauditz, Guido Sauter, Thorben Fründt, Sören Weidemann, Gisa Tiegs, Christoph Schramm, Nicola Gagliani, Penelope Pelczar, Samuel Huber

doi: 10.1136/gutjnl-2023-330856

June 12, 2024

Correction
Correction: Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer
Free

doi: 10.1136/gutjnl-2017-314408corr1

June 11, 2024

Recent advances in basic science
Nuclear receptors: pathophysiological mechanisms and drug targets in liver disease

Vanessa Dubois, Philippe Lefebvre, Bart Staels, Jerome Eeckhoute

doi: 10.1136/gutjnl-2023-331741

June 10, 2024

Inflammatory bowel disease
Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease

Thomas W Dennison, Rachel D Edgar, Felicity Payne, Komal M Nayak, Alexander D. B. Ross, Aurelie Cenier, Claire Glemas, Federica Giachero, April R Foster, Rebecca Harris, Judith Kraiczy, Camilla Salvestrini, Georgia Stavrou, Franco Torrente, Kimberley Brook, Claire Trayers, Rasa Elmentaite, Gehad Youssef, Bálint Tél, Douglas James Winton, Nefeli Skoufou-Papoutsaki, Sam Adler, Philip Bufler, Aline Azabdaftari, Andreas Jenke, Natasha G, Natasha Thomas, Erasmo Miele, Abdulrahman Al-Mohammad, Greta Guarda, Subra Kugathasan, Suresh Venkateswaran, Menna R Clatworthy, Tomas Castro-Dopico, Ondrej Suchanek, Caterina Strisciuglio, Marco Gasparetto, Seokjun Lee, Xingze Xu, Erica Bello, Namshik Han, Daniel R. Zerbino, Sarah A Teichmann, Josquin Nys, Robert Heuschkel, Francesca Perrone, Matthias Zilbauer

doi: 10.1136/gutjnl-2024-332043
GI cancer
PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma

Friederike L Keggenhoff, Darko Castven, Diana Becker, Stojan Stojkovic, Jovana Castven, Carolin Zimpel, Beate K Straub, Tiemo Gerber, Harald Langer, Patricia Hähnel, Thomas Kindler, Jörg Fahrer, Colm J O'Rourke, Ursula Ehmer, Anna Saborowski, Lichun Ma, Xin Wei Wang, Timo Gaiser, Matthias S Matter, Christian Sina, Stefanie Derer, Ju-Seog Lee, Stephanie Roessler, Bernd Kaina, Jesper B Andersen, Peter R Galle, Jens U Marquardt

doi: 10.1136/gutjnl-2023-331237
Editor’s quiz: GI snapshot
GI snapshot: arrhythmia, dysphagia and weight loss in a 71-year-old man

Martina De Siena, Loredana Gualtieri, Simone Varca, Maria Valeria Matteo, Valerio Pontecorvi, Vincenzo Bove, Cristiano Spada, Ivo Boškoski

doi: 10.1136/gutjnl-2023-331813
Gut microbiota
Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production

doi: 10.1136/gutjnl-2024-331880

June 08, 2024

Recent advances in basic science
Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia

Marietta Iacucci, Giovanni Santacroce, Snehali Majumder, Jennifer Morael, Irene Zammarchi, Yasuharu Maeda, David Ryan, Antonio Di Sabatino, Maria Rescigno, Maria R Aburto, John F Cryan, Subrata Ghosh

doi: 10.1136/gutjnl-2023-331579

June 05, 2024

Hepatology
Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma

Ao Chen, Vanilla Xin Zhang, Qingyang Zhang, Karen Man-Fong Sze, Lu Tian, Hongyang Huang, Xia Wang, Eva Lee, Jingyi Lu, Xueying Lyu, Man-Fong Joyce Lee, Chun Ming Wong, Daniel Wai-Hung Ho, Irene Oi-Lin Ng

doi: 10.1136/gutjnl-2024-331903
Colon
Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use

Georgios Polychronidis, Ming-Ming He, Mathew Vithayathil, Markus D Knudsen, Kai Wang, Mingyang Song

doi: 10.1136/gutjnl-2023-331729
Hepatology
Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a multicentre pragmatic randomised clinical trial

Amit G Singal, Manasa Narasimman, Darine Daher, Sruthi Yekkaluri, Yan Liu, MinJae Lee, Vanessa Cerda, Aisha Khan, Karim Seif El Dahan, Jennifer Kramer, Purva Gopal, Caitlin Murphy, Ruben Hernaez

doi: 10.1136/gutjnl-2024-332508

June 04, 2024

GI cancer
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer

Anna Brichkina, Miriam Ems, Roman Suezov, Rajeev Singh, Veronika Lutz, Felix S R Picard, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Michael Daude, Wibke E Diederich, Florian Finkernagel, Ho-Ryun Chung, Detlef K Bartsch, Katrin Roth, Corinna Keber, Carsten Denkert, Magdalena Huber, Thomas M Gress, Matthias Lauth

doi: 10.1136/gutjnl-2023-331854
Recent advances in clinical practice
Acute severe ulcerative colitis trials: the past, the present and the future

Sailish Honap, Vipul Jairath, Bruce E Sands, Parambir S Dulai, Silvio Danese, Laurent Peyrin-Biroulet

doi: 10.1136/gutjnl-2024-332489

May 31, 2024

Commentary
Glowing insights: tracking vedolizumab in the mucosa of patients with IBD via molecular endoscopy

Raja Atreya

doi: 10.1136/gutjnl-2024-332503
Commentary
Potential risk of porcine-derived pancreatic enzyme medication for the cross-species transmission of hepatitis E virus

Nicola Frericks, Volker Kinast, Eike Steinmann

doi: 10.1136/gutjnl-2024-332577
Pancreas
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

Markus Vogt, Nevenka Dudvarski Stankovic, Yiliam Cruz Garcia, Julia Hofstetter, Katharina Schneider, Filiz Kuybu, Theresa Hauck, Bikash Adhikari, Anton Hamann, Yamila Rocca, Lara Grysczyk, Benedikt Martin, Anneli Gebhardt-Wolf, Armin Wiegering, Markus Diefenbacher, Georg Gasteiger, Stefan Knapp, Dieter Saur, Martin Eilers, Mathias Rosenfeldt, Florian Erhard, Seychelle M Vos, Elmar Wolf

doi: 10.1136/gutjnl-2023-331519

May 30, 2024

Neurogastroenterology
Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue

Benjamin Jevans, Fay Cooper, Yuliia Fatieieva, Antigoni Gogolou, Yi-Ning Kang, Restuadi Restuadi, Dale Moulding, Pieter Vanden Berghe, Igor Adameyko, Nikhil Thapar, Peter W Andrews, Paolo De Coppi, Anestis Tsakiridis, Conor J McCann

doi: 10.1136/gutjnl-2023-331532

May 23, 2024

Recent advances in clinical practice
‘Unusual’ HCV genotype subtypes: origin, distribution, sensitivity to direct-acting antiviral drugs and behaviour on antiviral treatment and retreatment

Erwan Vo-Quang, Jean-Michel Pawlotsky

doi: 10.1136/gutjnl-2024-332177
Hepatology
Association between primary hypothyroidism and metabolic dysfunction-associated steatotic liver disease: an updated meta-analysis

Alessandro Mantovani, Alessandro Csermely, Josh Bilson, Niccolò Borella, Scoccia Enrico, Barbara Pecoraro, Emigela Shtembari, Riccardo Morandin, Stergios A Polyzos, Luca Valenti, Herbert Tilg, Christopher D Byrne, Giovanni Targher

doi: 10.1136/gutjnl-2024-332491

May 22, 2024

Hepatology
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis

Mrigya Babuta, Caroline Morel, Marcelle de Carvalho Ribeiro, Charles Calenda, Martí Ortega-Ribera, Prashanth Thevkar Nagesh, Christopher Copeland, Yuan Zhuang, Yanbo Wang, Yeonhee Cho, Radhika Joshi, Viliam Brezani, Danielle Hawryluk, Aditi Ashish Datta, Jeeval Mehta, Imad Nasser, Gyongyi Szabo

doi: 10.1136/gutjnl-2023-331447
Recent advances in clinical practice
Heavy arch: from inflammatory bowel diseases to metabolic disorders

Timon E Adolph, Moritz Meyer, Almina Jukic, Herbert Tilg

doi: 10.1136/gutjnl-2024-331914
Recent advances in basic science
Intravital imaging: dynamic insights into liver immunity in health and disease

Yuting Wang, Felix Heymann, Moritz Peiseler

doi: 10.1136/gutjnl-2023-331739

May 16, 2024

Commentary
Eosinophils: a novel therapeutic target to promote liver regeneration in acute liver injury?

Hong-Min Ni, Amaya Lopez-Pascual

doi: 10.1136/gutjnl-2024-332692
Letter
Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy

Gergő Berke, Miklós Sahin-Tóth

doi: 10.1136/gutjnl-2024-332818
Pancreas
The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

Juan Carlos López-Gil, Susana García-Silva, Laura Ruiz-Cañas, Diego Navarro, Adrián Palencia-Campos, Antonio Giráldez-Trujillo, Julie Earl, Jorge Dorado, Gonzalo Gómez-López, Ana Monfort-Vengut, Sonia Alcalá, Matthias M Gaida, Sandra García-Mulero, Pablo Cabezas-Sáinz, Sandra Batres-Ramos, Emma Barreto, Patricia Sánchez-Tomero, Mireia Vallespinós, Leah Ambler, Meng-Lay Lin, Alexandra Aicher, Ana García García de Paredes, Carolina de la Pinta, Alfonso Sanjuanbenito, Ignacio Ruz-Caracuel, Mercedes Rodríguez-Garrote, Carmen Guerra, Alfredo Carrato, Guillermo de Cárcer, Laura Sánchez, César Nombela-Arrieta, Elisa Espinet, Víctor Javier Sanchez-Arevalo Lobo, Christopher Heeschen, Bruno Sainz

doi: 10.1136/gutjnl-2023-330995

May 15, 2024

Letter
Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer

Shaida Ouladan, Elias Orouji

doi: 10.1136/gutjnl-2024-332325

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