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P2RY1

From Wikipedia, the free encyclopedia

P2RY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesP2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDsOMIM: 601167; MGI: 105049; HomoloGene: 1926; GeneCards: P2RY1; OMA:P2RY1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554

NP_001268945
NP_032798

Location (UCSC)Chr 3: 152.84 – 152.84 MbChr 3: 60.91 – 60.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[5]

Function

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The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169860Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027765Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
  6. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

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  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.