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DNA polymerase nu

From Wikipedia, the free encyclopedia
POLN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDsOMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181808

NM_001289803
NM_001289804
NM_181857

RefSeq (protein)

NP_861524

NP_001276732
NP_001276733
NP_862905

Location (UCSC)Chr 4: 2.07 – 2.24 MbChr 5: 34.16 – 34.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.[5] It is a family A DNA polymerase,[6] considered to be the least effective of the polymerase enzymes.[7] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130997Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045102Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Polymerase (DNA directed) nu".
  6. ^ Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
  7. ^ a b "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase nu