In Vivo and In Vitro Electrochemical Impedance Spectroscopy of Acute and Chronic Intracranial Electrodes
Abstract
:1. Summary
2. Data Description
2.1. Data Utility
2.2. Code Availability
3. Methods
3.1. Electrochemical Impedance Spectroscopy
3.2. Animal Ethics Statement
3.3. Data Collection
3.4. Setup and Solution Preparation
3.5. Data Analysis
- The Voigt measurement model,
- The standard deviations so obtained are strong functions of frequency. An empirical model,
- Subsequent regressions were weighted by 1/σ2, where σ was obtained from Equation (2).
4. User Notes
4.1. Data Validation—Process Model
4.2. Comparison of Two- and Three-Electrode Data
4.3. Comparison of In Vivo and In Vitro Data
4.4. Compliance of PalmSens Data with BAK
4.5. Impact of Temperature Regulation
4.6. Counter Electrode Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
aCSF | Artificial cerebrospinal fluid |
C | Counter electrode |
CPE | Constant phase element |
CSV | Comma-separated values (file format) |
DBS | Deep brain stimulation |
ECoG | Electrocorticography |
EIS | Electrochemical impedance spectroscopy |
ETI | Electrode–tissue interface |
IACUC | Institutional Animal Care and Use Committee |
NHP | Nonhuman primate |
PBS | Phosphate-buffered saline |
SNR | Signal-to-noise ratio |
R | Reference rlectrode |
RARC | Research Animal Resource Center |
W | Working electrode |
References
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Electrode Name | Form Factor | Contact Dimensions | Contact Surface Area | Material |
---|---|---|---|---|
Adtech BF BF08R-SP05X-000 | 8 cylindrical contacts | 1.57 mm contact height, 1.28 mm contact diameter, 2 mm spacing between contacts | 8.89 mm2 | 90% Pt/10% Ir |
Adtech depth RD10R-SP05X-000 | 10 cylindrical contacts | 2.29 mm contact height, 0.86 mm contact diameter, 2 mm spacing between contacts | 7.35 mm2 | 90% Pt/10% Ir |
Adtech Grid FG64C-SP10X-0CB | 64 contact grid w/circular contacts | 4 mm contact diameter, 10 mm spacing between contact centers | 2.3 mm2 | 90% Pt/10% Ir |
Adtech strip IS04R-SP10X-000 | 4 circular contacts, surface electrode | 4 mm contact diameter, 10 mm spacing between contact centers | 2.3 mm2 | 90% Pt/10% Ir |
CorTec Fetz Spinal Cord ECoG | 8-contact surface strip with circular contacts | 0.6 mm diameter, center-center spacing between 2 and 3 mm | 0.28 mm2 | 90% Pt/10% Ir |
CorTec Micro Square ECoG | 32 contact surface grid with circular contacts | 1 mm contact diameter, centers spaced 4.25 mm apart | 0.79 mm2 | 90% Pt/10% Ir |
Dixi Depth D08-15CM | 8 cylindrical contacts in two groups of four | 2 mm height, 0.8 mm diameter, 1.5 mm spacing between contacts, 15 mm spacing between groups | 6 mm2 | 90% Pt/10% Ir |
FHC Microelectrode | Single micro contact extended from a canula | 125 micron diameter platinum/iridium wire, extends up to 0.5mm from canula | not specified by manufacturer | 90% Pt/10% IrPlatinum black coating |
Hereaus NHP DBS | Segmented 12-channel DBS, 4 contact rings with 3 contacts per ring | Contacts are segmented from cylinders with 0.8 mm diameter, 0.5 mm height. 104.49° of arc per segment, 0.51 mm spacing between rings | 0.37 mm2 | 90% Pt/10% Ir |
MDT SenSight | DBS lead with 8 contacts in a 1-3-3-1 configuration (first and fourth are solid cylinders, middle two are segmented into 3 contacts each) | 1.5 mm cylinder height, 1.36 mm diameter, 0.5 mm spacing between | 9.31 mm2 | 90% Pt/10% Ir |
NeuroPace Depth DL-330-3.5 | 4 cylindrical contacts, depth electrode | 1.27 mm diameter, 2 mm hheight | 10 mm2 | 90% Pt/10% Ir |
NeuroPace strip CL-335-10 | 4 circular contacts, surface electrode | 3.175 mm diameter | 8 mm2 | 90% Pt/10% Ir |
NuMED for children DBS | 4 cylindrical contacts, depth electrode | 0.8 mm diameter, 0.5 mm height | 2.26 mm2 | 90% Pt/10% Ir |
Thomas Recording 3D Heptrode | 7 contacts exposed on electrode tip | Fiber with 100 micron diameter, 6 contacts approx. 50 microns in length and 10 microns in width on tip taper, one at tip terminus approx. 30 microns in length | approx. 3.6 mm2 total | platinum/tungsten |
Variable | Two-Electrode | Three-Electrode |
---|---|---|
Re, Ω | 10.57 ± 0.02 | 9.42 ± 0.02 |
Rt,a, kΩ | 4.0 ± 0.2 | 2.3 ± 0.1 |
Rd, kΩ | 19.2 ± 0.6 | 18.3 ± 1.1 |
Q, μF/s1−α | 7.0541 ± 0.2270 | 7.1622 ± 0.4054 |
α | 0.8801 ± 0.0028 | 0.8797 ± 0.0047 |
χ2/υ | 54 | 278 |
C, μF/cm2 | 19.3 | 19.3 |
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O’Sullivan, K.P.; Philip, B.J.; Baker, J.L.; Rolston, J.D.; Orazem, M.E.; Otto, K.J.; Butson, C.R. In Vivo and In Vitro Electrochemical Impedance Spectroscopy of Acute and Chronic Intracranial Electrodes. Data 2024, 9, 78. https://doi.org/10.3390/data9060078
O’Sullivan KP, Philip BJ, Baker JL, Rolston JD, Orazem ME, Otto KJ, Butson CR. In Vivo and In Vitro Electrochemical Impedance Spectroscopy of Acute and Chronic Intracranial Electrodes. Data. 2024; 9(6):78. https://doi.org/10.3390/data9060078
Chicago/Turabian StyleO’Sullivan, Kyle P., Brian J. Philip, Jonathan L. Baker, John D. Rolston, Mark E. Orazem, Kevin J. Otto, and Christopher R. Butson. 2024. "In Vivo and In Vitro Electrochemical Impedance Spectroscopy of Acute and Chronic Intracranial Electrodes" Data 9, no. 6: 78. https://doi.org/10.3390/data9060078