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Comparative genomics of high grade neuroendocrine carcinoma of the cervix

Fig 1

Somatic mutational landscape of high grade neuroendocrine carcinoma of the cervix.

(A) NECC somatic mutation burden expressed as somatic mutations per Mb. Gray color indicates sample with no available matched normal tissue. (B) Genes in COSMIC Cancer Gene Census with recurrent (>1) non-silent somatic mutations. (C) Copy number alterations in PI3-kinase pathway members PIK3CA and PTEN, as well as BCL2L11 which was identified as recurrently deleted in NECC (q = .04). NECC = small cell neuroendocrine carcinoma of the cervix, Mb = megabase.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0234505.g001