Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy
Fig 2
Twitch force characteristics of wild-type and BRAF-mutant hECTs.
(A) Cartoon of iPSC-derived hECT force data illustrating twitch characteristic parameters. (B-G) Mean (±SD) twitch parameters for wild-type (open bars, n = 7) and BRAF mutant (solid bars, n = 5) iPSC-hECTs tested on culture days 6 and 11, including developed force (B), 50% twitch duration (C), time to 50% contraction (D), time to 50% relaxation (E) and the maximum rates of contraction (F) and relaxation (G). * p < 0.05, ** p < 0.01, *** p < 0.001.
