Background: There are now a substantial number of controlled trials investigating the efficacy of acceptance and commitment therapy (ACT). This meta-analysis combined multiple well-controlled studies to help clarify the overall impact of ACT relative to waiting lists, psychological placebos, treatment as usual, and established therapies. Method: A comprehensive literature search produced 18 randomized controlled trials (n = 917) that were included in the final analyses. Effect size was computed with Hedges’s g which can be interpreted with Cohen’s convention of small (0.2), medium (0.5), and large (0.8) effects. Results: There was a clear overall advantage of ACT compared to control conditions (effect size = 0.42). The average ACT-treated participant was more improved than 66% of the participants in the control conditions. Analyzed separately ACT was superior to waiting lists and psychological placebos (effect size = 0.68) and treatment as usual (effect size = 0.42). However, ACT was not significantly more effective than established treatments (effect size = 0.18, p = 0.13). Also, ACT was not superior to control conditions for the distress problems (anxiety/depression: effect size = 0.03, p = 0.84). Conclusions: The results reveal that ACT is more effective than control conditions for several problem domains, but there is no evidence yet that ACT is more effective than established treatments.

1.
Hayes S, Luoma J, Bond F, Masuda A, Lillis J: Acceptance and commitment therapy: model, processes and outcomes. Behav Res Ther 2006;44:1–25.
2.
Zettle R, Hayes S: Dysfunctional control by client verbal behavior: the context of reason-giving. Anal Verbal Behav 1986;4:30–38.
3.
Eifert GH, Forsyth JP: Acceptance and Commitment Therapy for Anxiety Disorders. Oakland, New Harbinger Publications Inc, 2005.
4.
Zettle R: A Clinician’s Guide to Using Acceptance and Commitment Therapy in Treating Depression. Oakland, New Harbinger Publications Inc, 2007.
5.
Bond F, Bunce D: Mediators of change in emotion-focused and problem-focused worksite stress management interventions. J Occup Health Psychol 2000;5:156–163.
6.
Forman EM, Herbert J, Moitra E, Yeomans P, Geller P: A randomized controlled effectiveness trial of acceptance and commitment therapy and cognitive therapy for anxiety and depression. Behav Modif 2007;31:772–799.
7.
Lappalainen R, Lehtonen T, Skarp E, Taubert E, Ojanen M, Hayes SC: The impact of CBT and ACT models using psychology trainee therapists: a preliminary controlled effectiveness trial. Behav Modif 2007;31:488–511.
8.
Zettle R: Acceptance and commitment therapy (ACT) vs systematic desensitization in treatment of mathematics anxiety. Psychol Rec 2003;53:197–215.
9.
Zettle R, Rains J: Group cognitive and contextual therapies in treatment of depression. J Clin Psychol 1989;45:436–445.
10.
Dahl J, Wilson KG, Nilsson A: Acceptance and commitment therapy and the treatment of persons at risk for long-term disability resulting from stress and pain symptoms: a preliminary randomized trial. Behav Ther 2004;35:785–801.
11.
Gregg JA, Callaghan GM, Hayes S, Glenn-Lawson JL: Improving diabetes self-management through acceptance, mindfulness, and values: a randomized controlled trial. J Consult Clin Psychol 2007;75:336–343.
12.
Lillis J, Hayes S, Bunting K, Masuda A: A randomized controlled trial of acceptance and commitment therapy for weight control: preliminary test of a theoretical model. Behav Ther, in press.
13.
Lundgren T, Dahl J, Melin L, Kies B: Evaluation of acceptance and commitment therapy for drug refractory epilepsy: a randomized controlled trial in South Africa: a pilot study. Epilepsia 2006;47:2173–2179.
14.
Vowles KE, McNeil DW, Gross RT, McDaniel ML, Mouse A, Bates M, Gallimore P, McCall C: Effects of pain acceptance and pain control strategies on physical impairment in individuals with chronic low back pain. Behav Ther 2007;38:412–425.
15.
Bach P, Hayes S: The use of acceptance and commitment therapy to prevent the rehospitalization of psychotic patients: a randomized controlled trial. J Consult Clin Psychol 2002;70:1129–1139.
16.
Gaudiano BA, Herbert JD: Acute treatment of inpatients with psychotic symptoms using acceptance and commitment therapy: pilot results. Behav Res Ther 2006;44:415–437.
17.
Gifford EV, Kohlenberg B, Hayes SC, Pierson HM, Piasecki M, Antonuccio DO, Palm KM: Applying acceptance and the therapeutic relationship to smoking cessation: a randomized controlled trial. J Consult Clin Psychol, in press.
18.
Gifford EV, Kohlenberg BS, Hayes SC, Antonuccio DO, Piasecki MM, Rasmussen-Hall ML, Palm KM: Acceptance-based treatment for smoking cessation. Behav Ther 2004;35:689–705.
19.
Gratz KL, Gunderson JG: Preliminary data on an acceptance-based emotion regulation group intervention for deliberate self-harm among women with borderline personality disorder. Behav Ther 2006;37:25–35.
20.
Hayes SC, Wilson KG, Gifford EV, Bissett R, Piasecki M, Batten SV, Byrd M, Gregg J: A preliminary trial of twelve-step facilitation and acceptance and commitment therapy with polysubstance-abusing methadone-maintained opiate addicts. Behav Ther 2004;35:667–688.
21.
Woods DW, Wetterneck CT, Flessner CA: A controlled evaluation of acceptance and commitment therapy plus habit reversal for trichotillomania. Behav Res Ther 2006;44:639–656.
22.
Öst LG: Efficacy of the third wave of behavioral therapies: a systematic review and meta-analysis. Behav Res Ther 2008;46:296–321.
23.
Blackledge JT, Hayes S: Using acceptance and commitment training in the support of parents of children diagnosed with autism. Child Fam Behav Ther 2006;28:1–18.
24.
Brown RA, Palm KM, Strong DR, Lejuez CW, Kahler CW, Zvolensky MJ, Hayes SC, Wilson KG, Gifford EV: Distress tolerance treatment for early-lapse smokers: rationale, program description and preliminary findings. Behav Modif 2008;32:302–332.
25.
Dalrymple KL, Herbert JD: Acceptance and commitment therapy for generalized social anxiety disorder: a pilot study. Behav Modif 2007;31:543–568.
26.
Masuda A, Hayes SC, Sackett CF, Twohig MP: Cognitive defusion and self-relevant negative thoughts: examining the impact of a ninety year old technique. Behav Res Ther 2004;42:477–485.
27.
McCracken LM, Vowles KE, Eccleston C: Acceptance-based treatment for persons with complex, long standing chronic pain: a preliminary analysis of treatment outcome in comparison to a waiting phase. Behav Res Ther 2005;43:1335–1346.
28.
Ossman WA, Wilson KG, Storaasli RD, McNeill JW: A preliminary investigation of the use of acceptance and commitment therapy in group treatment for social phobia. Int J Psychol Psychol Ther 2006;6:397–416.
29.
Roemer L, Orsillo SM: An open trial of an acceptance-based behavior therapy for generalized anxiety disorder. Behav Ther 2007;38:72–85.
30.
Twohig MP, Hayes SC, Masuda A: A preliminary investigation of acceptance and commitment therapy as a treatment for chronic skin picking. Behav Res Ther 2006;44:1513–1522.
31.
Twohig MP, Shoenberger D, Hayes S: A preliminary investigation of acceptance and commitment therapy as a treatment for marijuana dependence in adults. J Appl Behav Anal 2007;40:619–632.
32.
Twohig MP, Woods DW: A preliminary investigation of acceptance and commitment therapy and habit reversal as a treatment for trichotillomania. Behav Ther 2004;35:803–820.
33.
Vowles KE, McCracken LM, Eccleston C: Processes of change in treatment for chronic pain: the contributions of pain, acceptance, and catastrophizing. Eur J Pain 2007;11:779–787.
34.
Wicksell RK, Melin L, Olsson GL: Exposure and acceptance in the rehabilitation of adolescents with idiopathic chronic pain – A pilot study. Eur J Pain 2007;11:267–274.
35.
Borenstein M, Rothstein H: Comprehensive Meta-Analysis: A Computer Program for Research Synthesis. New Jersey, Biostat Inc, 1999.
36.
Rosenthal R: Meta-Analytic Procedures for Social Research. London, Sage, 1991.
37.
Hedges LV, Olkin I: Statistical Methods for Meta-Analysis. Orlando, Academic Press, 1985.
38.
Cohen J: Statistical Power Analysis for the Behavioral Sciences, ed 2. Hillsdale, Erlbaum, 1988.
39.
Borenstein M, Hedges LV, Rothstein H: Introduction to Meta-Analysis. Chichester, Wiley, 2007.
40.
Bakan D: On Method. San Francisco, Josey-Bass, 1967.
41.
McNemar Q: At random: sense and nonsense. Am Psychol 1960;15:295–300.
42.
Smart RG: The importance of negative results in psychological research. Can Psychol 1964;5A:225–232.
43.
Sterling TD: Publication decisions and their possible effects on inferences drawn from tests of significance – or vice versa. J Am Stat Assoc 1959;54:30–40.
44.
Rosenthal R, Rubin DB: Comment: assumptions and procedures in the file drawer problem. Stat Sci 1988;3:120–125.
45.
Jadad A, Moore A, Carroll D, Jenkinson C, Reynolds D, Gavaghan D, McQuay H: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1–12.
46.
Gellis ZD, Kenaley B: Problem-solving therapy for depression in adults: a systematic review. Res Soc Work Pract 2008;18:117–131.
47.
Powers MB, Sigmarsson SR, Emmelkamp PM: A meta-analytic review of social phobia treatments. Int J Cogn Ther 2008;1:94–113.
48.
Hayes SC: Acceptance and commitment therapy, relational frame theory, and the third wave of behavioral and cognitive therapies. Behav Ther 2004;35:639–665.
49.
Feske U, Chambless DL: Cognitive behavioral versus exposure only treatment for social phobia: a meta-analysis. Behav Ther 1995;26:695–720.
50.
Powers MB, Smits J, Telch MJ: Disentangling the effects of safety-behavior utilization and safety-behavior availability during exposure-based treatment: a placebo-controlled trial. J Consult Clin Psychol 2004;72:448–454.
51.
Lundgren T, Dahl J, Hayes S: Evaluation of mediators of change in the treatment of epilepsy with acceptance and commitment therapy. J Behav Med 2008;31:225–235.
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