Jakob Riis

Technology at its best

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🧐 Who could have thought that merging micropatterning, standardization and engineering can have a huge impact on the way organoids and spheroids are cultured, and imaged? 😍 Easy imaging, no spheroid or organoid loss during medium renewal, high degree of size homogeneity, and no organoid merging looks like a dream, right? 🍒 🍰 The SmartSphero Plate by 4Dcell allows make this dream come true, and cherry on the cake, it is now exclusively distributed by Cherry,

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Beckman Coulter Diagnostics Expands Diagnostics Partnership with MeMed In an exciting development, Beckman Coulter Diagnostics, the biomedical testing company of Danaher Corporation, has extended its partnership with Israeli medtech company MeMed , focusing on host immune response diagnostics. Kevin O'Reilly, President of Beckman Coulter, expressed enthusiasm, stating, "We are excited to extend our partnership with MeMed by expanding market access to the MeMed Key and BV assay. These MeMed innovations complement Beckman Coulter's portfolio of host response diagnostics. "The expanded partnership grants Beckman Coulter the status of an authorized distributor for the MeMed Key Immunoassay System and MeMed Key, a compact immunoassay analyzer. The MeMed BV assay, a rapid immunoassay test designed to distinguish between bacterial and viral infections, will now be accessible through Beckman Coulter's distribution channels. Eran Eden and co-founder of MeMed , shared his excitement, "We're excited to expand our partnership with Beckman Coulter, taking an additional step forward in our shared mission to advance pioneering host-response solutions." He highlighted the objectives of educating the market and broadening patient access to MeMed BV through a strategic hub and spoke model. The MeMed BV assay, which provides results within 15 minutes and has a >99% negative predictive value to rule out bacterial infection, complements Beckman Coulter's existing portfolio of host response diagnostics. This partnership aims to create a synergistic ecosystem that aids clinicians in distinguishing between bacterial and viral infections with unprecedented ease and precision. https://lnkd.in/ep4BziDZ Be sure to follow Practical Patient Care on LinkedIn for more industry news and insights. You can also read out latest edition: https://lnkd.in/e39XTWsB #PracticalPatientCare #HostImmuneResponse #BacterialViralDiagnostics #AntimicrobialResistance #DiagnosticInnovation

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TTV assay is now available

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Thanks to Dr. Miyara for sharing your insights and how we can better partner with you to enable faster patient diagnosis and link to care.

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Preeclampsia is a life-threatening blood pressure disorder that can occur during pregnancy and the postpartum period. Until recently, the current tools available for clinical diagnosis of preeclampsia have provided ambiguous results to clinicians. Read @ClinicalLabProducts below to learn about how lab directors can contribute to improved patient outcomes by incorporating new biomarker-based assays into the lab. #thermofisheremp

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𝗕𝗶𝗹𝗲 𝗮𝗰𝗶𝗱 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺: 𝗽𝗿𝗼𝗺𝗶𝘀𝗶𝗻𝗴 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗻 𝘀𝗽𝗶𝘁𝗲 𝗼𝗳 𝗿𝗲𝗰𝗲𝗻𝘁 𝘀𝗲𝘁𝗯𝗮𝗰𝗸𝘀? The understanding of bile acid metabolism and its importance in host-microbiome interaction and the pathophysiological processes in mutliple diseases has made big strides in recent years. As a therapy for Primary Biliary Cholangitis (PBC), the bile acid analog obeticholic acid has also shown that there is therapeutic potential in targeting bile acid metabolism. However, there have been recent setbacks such as FDA's denial to approve obeticholic acid for NASH. That is the backdrop against which the authors of this review discuss their perspective on why targeting bile acids still has substantial therapeutic potential, providing a very comprehensive discussion about regulation and pathophysiology of bile acid metabolism in the process. https://lnkd.in/eAjVUXxJ. I do like the view of bile acid metabolism as a tree with multiple branches. Full publication: Fleishman, J.S., Kumar, S. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets. Sig Transduct Target Ther9, 97 (2024). https://lnkd.in/etbFF5pg. Freely available under a Creative Commons license: https://lnkd.in/dyuva2r8 #science #metabolism #pharmacology

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Intracranial Hemorrhage Diagnosis and Treatment Market 𝐒𝐢𝐳𝐞 𝐀𝐧𝐝 𝐅𝐨𝐫𝐞𝐜𝐚𝐬𝐭 Intracranial Hemorrhage Diagnosis and Treatment Market size is expected to develop revenue and exponential market growth at a remarkable CAGR during the forecast period from 2024–2031. The comprehensive report of the Intracranial Hemorrhage Diagnosis and Treatment Market will analyse data changes and their impact on the market at the global level. It also analyses the overall growth of companies in the market and their abilities to manage and control profit levels, which is highly important to any investor wishing to open and expand a company within the same market. ➢𝐓𝐨𝐩 𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 𝐦𝐞𝐧𝐭𝐢𝐨𝐧𝐞𝐝 𝐚𝐬 𝐛𝐞𝐥𝐨𝐰: ➢ Cerus➢ Mount Sinai West ➢ Safeguard Medical ➢ NeuroCare.AI ➢ Gauss Surgical, now a part of Stryker ➢ AANS/CNS Joint Cerebrovascular Section ➢ Ovesco Endoscopy AG ➢ RevMedx➢ Acasti Pharma Inc. ➢ BrainSpace ➢ New Jersey Brain and Spine ➢ NeuroPixel.AI ➢ OASIS - Organizing to Advance Solutions in the Sahel ➢ Grace Therapeutics ➢ Remedy Pharmaceuticals, Inc. ➢ NKA Bio | Techstars '24 ➢ Cayuga Biotech ➢ Retina Center of NJ ➢ Surgitech UAE ➢ Himanshu Gupta ➢ Avana Health ➢ SILVERT MEDICAL ➢ Perspective Medical ➢ Hemorai➢ Island Retina ➢ South Carolina Retina Institute ➢ Sunset Neurological & Psychiatry Group ➢ First Care Products ➢ Salt Creek International Women's Health Foundation ➢ Embologic, Inc. ➢ Hesperidin-Diosmin ➢ Dr Joshi's Neuro Spine Clinic ➢ Rhovica Neuroimaging AG ➢ diosmin:hesperidin(9:1) ➢ FLEVA Medical Centre ➢ Eye Loungeoptical ➢ Digestive Disease Interventions ➢ VDS Bunte Übung ➢ NYC Retina ➢ Boulder Neurology and Concussion, PLLC #data #sales #marketresearch #research #entrepreneur #businessstrategy #technology #data #sales #datacollection #salesfunnel #contentmarketing #bhfyp #size #forecast # #Share #Scope #Opportunities #Analysis #IntracranialHemorrhageDiagnosisandTreatment

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Another thoughtful piece from Mike Rea. My take: The hedgehog mindset based on linear (Newtonian) models has significant limitations, especially when one comes to appreciate Complex Adaptive Systems (CAS) that operate in non-linear, fundamentally unpredictable dynamics. “Fixing your idea as the only lens through which to see things (‘it’s amyloid, stupid’ or ‘it’s about reducing calories, obviously’) changes mindset to confirmatory versus exploratory. It becomes a distortion in your prediction.” It is clear execution AND adaptability to emerging landscape and insights (exploratory in nature) that is the combo one needs, especially in biology and drug development. Place your bets, execute, but don’t be surprised when you are wrong. Be open to new possibilities and pivot. A look back to development programs provides a plethora of evidence.

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Bringing tests closest to patients is a key challenge for in vitro diagnostic players. More and more assays are carried out directly within emergency departments or intensive care units, or outside the hospital in physician offices and healthcare facilities.  Learn more about decentralized testing in bioMérieux 2023 Annual Report: https://lnkd.in/eQtnGA94

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Choosing the right filling and sealing phase is crucial for your diagnostic product’s success. Whether you’re just starting out or ready for large-scale production, understanding the options—manual, semi-automated, or fully automated—can make a huge difference in costs and outputs. Find out which phase is best for your needs and optimize your production process from molding to final assembly: https://lnkd.in/e6xttjFf #Diagnostics #MedicalDevices #ContractManufacturing #Manufacturing #FillingandSealing #Automation 

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Are increasing fluid volumes creating challenges as you scale your mAbs process? Avantor can help you to plan early, with the right qualified fluid handling and transfer equipment, for a smooth transition from small scale to manufacturing volumes. Learn more about how you can avoid costly delays and product loss during mAbs scale-up: https://lnkd.in/g2ZmQ2FN

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✍🏼From UV-visible spectroscopy, it was observed that the 📝 direct and indirect energy band gaps decreased with 📝 increasing concentration of 🤔 TeO2, while the refractive index increased. https://lnkd.in/ga_gwUQm

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#Platelets are vital components of our #blood and play a crucial role in #hemostasis and #wound #healing. The discoid shape of resting platelets is mechanically supported by #microtubule bundles called #marginal #band, which reorganize extensively upon platelet activation. While microtubules have long been recognized as key players in platelet function, the presence of #actin filaments within these microtubules has remained elusive until now. In an article recently published in #NatureCommunications (Nature Portfolio), Chisato T. and colleagues from the University of Bristol shed light on the intricate #structure and #dynamics of microtubules inside platelets and #HAP1 #cells, specifically focusing on the presence of actin filaments within these structures. The authors employed #electron #cryotomography (CryoET) to visualize cytoskeletal components in their natural state, revealing unprecedented insights into their internal #organization and functional interplay between these two #cytoskeletal components.   https://lnkd.in/dEfUrsy8 The cryoET data revealed the presence of three types of actin filaments inside the HAP1 cells: #cofilin bound Class I filaments, Class II filaments with a morphology distinct from the standard F-actin helical morphology and a novel type, Class III filaments, which did not exhibit an F-actin-like power spectrum. The authors also observed F-actin filaments with breaks or intermediate stages, suggesting the possibility of luminal actin as a #dynamic structure. In contrast, only Class I F-actin filaments within microtubules were seen inside the platelets. CryoET examination of in vitro reconstituted F-actin filaments with or without cofilin inside the microtubules suggested that cofilin is not essential for F-actin incorporation inside microtubules. This discovery challenges previous assumptions regarding the composition of platelet microtubules and expands our understanding of the complex interplay between actin and microtubule cytoskeletal components. The discovery of actin filaments within platelet microtubules has important implications for our understanding of #platelet #biology and #cellular #processes. Platelets are vital for #hemostasis and #wound #healing, and microtubules play a crucial role in their function. The presence of actin filaments within microtubules suggests an intricate coordination between these cytoskeletal components, potentially influencing platelet function and behavior. These findings have far-reaching implications for our understanding of platelet biology and for the development of #targeted #therapeutics. By unravelling the #complex #architecture of platelet microtubules, researchers can gain a deeper understanding of how platelets respond to external stimuli and how they contribute to various #physiological and #pathological conditions such as #hereditary #thrombocytopenia.   #Cytoskeleton, #CellBiology, #MarginalBand, #Platelet, #Microtubules, #Actin

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Exploring the Future of the #Hematology Analyzers Market The global hematology analyzers market, valued at $7.6 billion in 20XX, is set to expand to $10.6 billion by 20XX, at a CAGR of 6.9%. This growth is driven by increasing #blood donations, a higher incidence of blood disorders, and ongoing technological advancements in #hematology analyzers and #reagents. Our detailed research includes industry trend analysis, pricing structures, patent information, and key insights from conferences and webinars. It also examines the roles of key stakeholders and market buying behaviors. Discover the key factors driving this market's expansion and stay ahead with the latest industry insights. https://lnkd.in/gzdjxVr #HematologyMarket #HealthcareTrends #MedicalTechnology #BloodHealth #MarketResearch

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