Your search for: 'author:("Möller, Hans-Jürgen")' has returned 3 results. (0.017s) Save search

Authors: Teipel, Stefan J. | Meindl, Thomas | Wagner, Maximilian | Kohl, Thomas | Bürger, Katharina | Reiser, Maximilian F. | Herpertz, Sabine | Möller, Hans-Jürgen | Hampel, Harald

Article Type: Research Article

Abstract: The reduced risk of dementia in high-educated individuals has been suggested to reflect brain reserve capacity. In the present study, we determined the association between integrity of white matter microstructure and education separately in twenty-one patients with clinically probable Alzheimer's disease (AD) and 18 healthy elderly subjects. We used fractional anisotropy derived from high-resolution diffusion-tensor weighted imaging at 3 Tesla as an in vivo marker of white matter microstructure. Based on multivariate network analysis, more years of education were associated with reduced white matter integrity of medial temporal lobe areas and association fiber tracts when age, gender, and dementia severity …had been controlled for (p < 0.001). In controls, higher education was associated with greater white matter integrity in medial temporal lobe areas and association fiber tracts (p < 0.001). In multiple regression models, education was the main factor accounting for fiber tract integrity even when occupation was taken into account. Reduced fiber tract integrity with higher education at the same level of cognitive impairment in AD patients and higher fiber tract integrity with higher education in similar white matter areas in cognitively healthy controls agrees with the hypothesis that white matter microstructure may contribute to brain reserve capacity in humans. Show more

Keywords: Aging, Alzheimer's disease, brain reserve capacity, cortical connectivity, diffusion tensor imaging (DTI), education

DOI: 10.3233/JAD-2009-1077

Citation: Journal of Alzheimer's Disease, vol. 17, no. 3, pp. 571-583, 2009

Authors: Bokde, Arun L.W. | Karmann, Michaela | Born, Christine | Teipel, Stefan J. | Omerovic, Muamer | Ewers, Michael | Frodl, Thomas | Meisenzahl, Eva | Reiser, Maximilian | Möller, Hans-Jürgen | Hampel, Harald

Article Type: Research Article

Abstract: In subjects with mild cognitive impairment (MCI), memory disorders indicate a high risk for conversion to Alzheimer's disease (AD). The objective of this study was to delineate the differences in brain activation between amnestic MCI and age-matched healthy controls (HC) during a verbal working memory task. The verbal working memory task was a delay match to sample design. Brain activation was measured using functional magnetic resonance imaging. There were 8 subjects in each group and were matched for performance. The task was analyzed as an event-related design. Group differences were calculated using Analysis of Covariance (ANCOVA) with statistical significance at …p<0.05 corrected. Both groups activated a wide network in the posterior and frontal areas of the brain. There was higher activation in the parietal and frontal lobes in the MCI compared to the HC during the maintenance phase. There were no areas in the HC that activated higher than the MCI subjects. Response time in the task in the HC group was correlated to the left hippocampus during encoding phase and to the parietal and frontal areas during the recall phase. In the MCI group, there was strong correlation to the inferior and middle temporal gyrii during encoding, the middle frontal gyrus during the maintenance phase, and hippocampus during recall phase. The activation differences between groups may be compensatory mechanisms within the MCI group for the effects of the putative AD neuropathology. This has been the first study that has examined verbal working memory in MCI. Show more

Keywords: Face matching, functional magnetic resonance imaging, location matching, object matching, visual system

DOI: 10.3233/JAD-2010-091054

Citation: Journal of Alzheimer's Disease, vol. 21, no. 1, pp. 103-118, 2010

Authors: Buschert, Verena C. | Friese, Uwe | Teipel, Stefan J. | Schneider, Philine | Merensky, Wibke | Rujescu, Dan | Möller, Hans-Jürgen | Hampel, Harald | Buerger, Katharina

Article Type: Research Article

Abstract: Recent studies have shown that patients with Alzheimer's disease (AD) and its possible prodromal stage mild cognitive impairment benefit from cognitive interventions. Few studies so far have used an active control condition and determined effects in different stages of disease. We evaluated a newly developed 6-month group-based multicomponent cognitive intervention in a randomized controlled pilot study on subjects with amnestic mild cognitive impairment (aMCI) and mild AD patients. Forty-three subjects with aMCI and mild AD were recruited. Primary outcome measures were change in global cognitive function as determined by the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and the Mini Mental …Status Examination (MMSE). Secondary outcomes were specific cognitive and psychopathological ratings. Thirty-nine patients were randomized to intervention groups (IGs: 12 aMCI, 8 AD) and active control groups (CGs: 12 aMCI, 7 AD). At the end of the study, we found significant improvements in the IGMCI compared to the CGMCI in the ADAS-cog (p = 0.02) and for the secondary endpoint Montgomery Asberg Depression Rating Scale (MADRS) (p < 0.01) Effects on the MMSE score showed a non-significant trend (p = 0.07). In AD patients, we found no significant effect of intervention on the primary outcome measures. In conclusion, these results suggest that participation in a 6-month cognitive intervention can improve cognitive and non-cognitive functions in aMCI subjects. In contrast, AD patients showed no significant benefit from intervention. The findings in this small sample support the use of the intervention in larger scales studies with an extended follow-up period to determine long-term effects. Show more

Keywords: Alzheimer's disease, cognitive intervention, cognitive stimulation, cognitive training, mild cognitive impairment, stage-specific

DOI: 10.3233/JAD-2011-100999

Citation: Journal of Alzheimer's Disease, vol. 25, no. 4, pp. 679-694, 2011