Your search for: 'author:("Hou, Yan")' has returned 8 results. (0.023s) Save search

Authors: Hou, Yan | Yu, Young-Beob | Liu, Gengtao | Luo, Yuan

Article Type: Research Article

Abstract: Substantial evidence supports a central role of Aβ in the pathogenesis of Alzheimer's disease (AD). We have demonstrated that FLZ, a synthetic cyclic analogue of natural squamosamide, exhibits neuroprotective actions in cells and mouse models, suggesting future investigation of FLZ as a candidate compound for the treatment of AD. In this study, we found that the production of amyloid-β (Aβ) was reduced by FLZ in Aβ-expressing neuroblastoma cells, and correlated with an increase in the soluble α-secretase derived fragment of the amyloid-β protein precursor (sAβPPα) in the medium. Moreover, the active form of ADAM10 and AβPP were elevated at the …cell surface of FLZ-treated cells, consistent with an enhanced co-localization of ADAM10 and AβPP on the membrane. Pretreatment with brefeldin, a protein trafficking inhibitor, blocked FLZ-induced translocation of ADAM10 to the cell surface and release of sAβPPα to the culture medium. Furthermore, oral administration of FLZ to APPswe/PS1 transgenic mice significantly reduced the levels of Aβ, paralleling with activation of ADAM10, in the hippocampus. In silico prediction indicates that the structure of FLZ is compatible with the drug-like rules for absorption and permeability. These findings suggest that FLZ reduces Aβ production by promoting AβPP non-amyloidogenic α-secretase processing. As such, FLZ may have therapeutic potential for the treatment of AD. Show more

Keywords: Amyloid-β, amyloid-β protein precursor (AβPP) processing, natural compound, α-secretase

DOI: 10.3233/JAD-2009-1133

Citation: Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 153-165, 2009

Authors: Hou, Yan-e | Wang, Chunxiao | Wang, Congran | Fan, Gaojuan

Article Type: Research Article

Abstract: Multi-compartment vehicle routing problem (MCVRP) is an extension of the classical capacitated vehicle routing problem where products with different characteristics are transported together in one vehicle with multiple compartments. This paper deals with this problem, whose objective is to minimize the total travel distance while satisfying the capacity and maximum route length constraints. We proposed a hybrid iterated local search metaheuristic (HILS) algorithm to solve it. In the framework of iterated local search, the current solution was improved iteratively by five neighborhood operators. For every obtained neighborhood solution after the local search procedure, a large neighborhood search-based perturbation method was …executed to explore larger solution space and get a better neighborhood solution to take part in the next iteration. In addition, the worse solutions found by the algorithm were accepted by the nondeterministic simulated annealing-based acceptance rule to keep the diversification of solutions. Computation experiments were conducted on 28 benchmark instances and the experimental results demonstrate that our presented algorithm finds 17 new best solutions, which significantly outperforms the existing state-of-the-art MCVRP methods. Show more

Keywords: Multi-compartment vehicle routing problem, hybrid metaheuristic, iterated local search, large neighborhood search, simulated annealing

DOI: 10.3233/JIFS-223404

Citation: Journal of Intelligent & Fuzzy Systems, vol. 45, no. 1, pp. 257-268, 2023

Authors: Zhu, Wei-Qun | Liang, Pan | Wang, Li-Jun | Hou, Yan-Ru

Article Type: Research Article

Abstract: In this paper, we investigate the multiple attribute decision making (MADM) problems with triangular fuzzy information. Motivated by the ideal of Bonferroni mean, we develop the aggregation techniques called the triangular fuzzy Bonferroni mean (TFBM) operator for aggregating the triangular fuzzy information. We study its properties and discuss its special cases. For the situations where the input arguments have different importance, we then define the triangular fuzzy weighted Bonferroni mean (TFWBM) operator, based on which we develop the procedure for multiple attribute decision making under the triangular fuzzy environments. Finally, a practical example for evaluating the modernization development of Chinese …traditional medicine industry is given to verify the developed approach and to demonstrate its practicality and effectiveness. Show more

Keywords: Multiple attribute decision making (MADM), triangular fuzzy numbers, Bonferroni mean, triangular fuzzy Bonferroni mean (TFBM) operator, triangular fuzzy weighted Bonferroni mean (TFWBM) operator, Chinese traditional medicine industry, modernization development

DOI: 10.3233/IFS-131092

Citation: Journal of Intelligent & Fuzzy Systems, vol. 29, no. 4, pp. 1265-1272, 2015

Authors: WANG, Shu-guang | LIN, Xian-gui | YIN, Rui | HOU, Yan-lin

Article Type: Research Article

Abstract: The effect of inoculation with arbuscular mycorrhiza (AM) fungi (Acaulospora lavis) on the degradation of di (2-ethylhexyl) phthalate (DEHP) in soil was studies. Cowpea plants (Pigna sinensis) were used as host plants and grown in a specially designed rhizobox. The experimental results indicated that, both in sterile and non-sterile soil, mycorrhizal colonization rates were much higher in the mycorrhizal plants than in the non-mycorrhizal plants. Addition of 4 mg/kg DEHP slightly affected mycorrhizal colonization, but the addition of 100 mg/kg DEHP significantly decreased mycorrhizal colonization. DEHP degradation in the mycorrhizosphere (Ms) and hyphosphere (Hs), especially in the Hs, increased after …inoculation with Acaulospora lavis. It is concluded that mycorrhizal hyphae play an important role in the plant uptake, degradation and translocation of DEHP. The mechanism might be attributed to increased numbers of bacteria and actinomycetes and activity of dehydrogenase, urease and acid phosphatase in the Ms and Hs by mycorrhizal fungi. Show more

Keywords: AM fungi, inoculation, DEHP, concentration, degradation

Citation: Journal of Environmental Sciences, vol. 16, no. 3, pp. 458-461, 2004

Authors: Pan, Chang-Jiang | Hou, Yan-Hua | Zhang, Bin-Bin | Zhang, Lin-Cai

Article Type: Research Article

Abstract: This paper presents a simple method to sequentially immobilize poly (ethylene glycol) (PEG) and albumin on titanium surface to enhance the blood compatibility. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated that PEG and albumin were successfully immobilized on the titanium surface. Water contact angle results showed a better hydrophilic surface after the immobilization. The immobilized PEG or albumin can not only obviously prevent platelet adhesion and activation but also prolong activated partial thromboplastin time (APTT), leading to the improved anticoagulation. Moreover, immobilization of albumin on PEG-modified surface can further improve the anticoagulation. The approach in the present …study provides an effective and efficient method to improve the anticoagulation of blood-contact biomedical devices such as coronary stents. Show more

Keywords: Titanium, surface modification, anticoagulation, PEG, albumin

DOI: 10.3233/BME-130868

Citation: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 781-787, 2014

Authors: Wang, Yaoqin | Xu, Suming | Wang, Yonglian | Qi, Gaimei | Hou, Yan | Sun, Chunqing | Wu, Xueqing

Article Type: Research Article

Abstract: BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a major cause of anovulatory infertility. Some studies showed that miRNAs were used as diagnostic/prognostic biomarkers for various diseases. OBJECTIVE: To identify candidate miRNAs in Granulosa Cells (GCs) of PCOS and evaluate their potential values for PCOS diagnosis. METHODS: We screened differentially expressed miRNAs in GCs between PCOS and controls by the microarray data from the GEO database. GCs were collected from 21 controls and 24 PCOS. The candidate miRNAs were verified by qRT-PCR. The correlation was investigated between candidate miRNAs and clinical characteristics in participants. Diagnostic value of candidate miRNAs was analyzed by …receiver operating characteristic (ROC) curve. RESULTS: Seven miRNAs were differentially expressed in PCOS compared with controls. Furthermore, the validation results demonstrated that hsa-miR-3188 and hsa-miR-3135b showed higher levels in GCs with PCOS patients (p < 0.05). In addition, the expressions of hsa-miR-3188 and hsa-miR-3135b were negative correlated with FSH and hsa-miR-3188 was positive correlated with BMI (p < 0.05). ROC analysis indicated that hsa-miR-3188 and hsa-miR-3135b could differentiate PCOS from controls, and the hsa-miR-3188/3135b improved the predictive accuracy for PCOS. CONCLUSIONS: The expressions of hsa-miR-3188 and hsa-miR-3135b in human GCs were significantly associated with PCOS. Moreover, the hsa-miR-3188/3135b has certain diagnostic value for distinguishing PCOS. Show more

Keywords: Granulosa cells, hsa-miR-3188, hsa-miR-3135b, polycystic ovary syndrome

DOI: 10.3233/THC-181510

Citation: Technology and Health Care, vol. 27, no. 6, pp. 579-587, 2019

Authors: Tchantchou, Flaubert | Lacor, Pascale N. | Cao, Zhiming | Lao, Lixing | Hou, Yan | Cui, Changhai | Klein, William L. | Luo, Yuan

Article Type: Research Article

Abstract: Loss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of AD. Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. This study aims to identify the constituents that contribute to EGb 761-induced neurogenesis. Among the constituents tested, bilobalide and quercetin significantly increased cell proliferation in the hippocampal neurons in a dose-dependent manner. Bilobalide and quercetin also enhanced phosphorylation of …cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain. Immunofluorescence staining of synaptic markers shows remarkable dendritic processes in hippocampal neurons treated with either quercetin or bilobalide. Furthermore, both constituents restored amyloid-β oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB. The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB. Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation. Show more

Keywords: Amyloid-beta derived diffusible ligands (ADDL), bilobalide, CREB, neurogenesis, quercetin, synaptogenesis

DOI: 10.3233/JAD-2009-1189

Citation: Journal of Alzheimer's Disease, vol. 18, no. 4, pp. 787-798, 2009

Authors: Chen, Yong-Ping | Gu, Xiao-Jing | Song, Wei | Hou, Yan-Bing | Ou, Ru-Wei | Zhang, Ling-Yu | Liu, Kun-Cheng | Su, Wei-Ming | Cao, Bei | Wei, Qian-Qian | Zhao, Bi | Wu, Ying | Shang, Hui-Fang

Article Type: Research Article

Abstract: Background: Genetic studies have indicated that variants in several lysosomal genes are risk factors for idiopathic Parkinson’s disease (PD). However, the role of lysosomal genes in PD in Asian populations is largely unknown. Objective: This study aimed to analyze rare variants in lysosomal related genes in Chinese population with early-onset and familial PD. Methods: In total, 1,136 participants, including 536 and 600 patients with sporadic early-onset PD (SEOPD) and familial PD, respectively, underwent whole-exome sequencing to assess the genetic etiology. Rare variants in PD were investigated in 67 candidate lysosomal related genes (LRGs), including 15 lysosomal function-related genes and 52 …lysosomal storage disorder genes. Results: Compared with the autosomal dominant PD (ADPD) or SEOPD cohorts, a much higher proportion of patients with multiple rare damaging variants of LRGs were found in the autosomal recessive PD (ARPD) cohort. At a gene level, rare damaging variants in GBA and MAN2B1 were enriched in PD, but in SCARB2 , MCOLN1 , LYST , VPS16 , and VPS13C were much less in patients. At an allele level, GBA p. Leu483Pro was found to increase the risk of PD. Genotype-phenotype correlation showed no significance in the clinical features among patients carrying a discrepant number of rare variants in LRGs. Conclusion: Our study suggests rare variants in LRGs might be more important in the pathogenicity of ARPD cases compared with ADPD or SEOPD. We further confirm rare variants in GBA are involve in PD pathogenecity and other genes associated with PD identified in this study should be supported with more evidence. Show more

Keywords: Parkinson’s disease, lysosomal genes, rare variants, burden analysis, genotype-phenotype correction

DOI: 10.3233/JPD-212658

Citation: Journal of Parkinson's Disease, vol. 11, no. 4, pp. 1845-1855, 2021