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Authors: George, Daniel R.

Article Type: Book Review

DOI: 10.3233/JAD-220791

Citation: Journal of Alzheimer's Disease, vol. 89, no. 4, pp. 1503-1505, 2022

Authors: George, Daniel R. | D'Alton, Simon

Article Type: Review Article

DOI: 10.3233/JAD-140707

Citation: Journal of Alzheimer's Disease, vol. 40, no. 4, pp. 1061-1062, 2014

Authors: D'Alton, Simon | George, Daniel R.

Article Type: Research Article

Abstract: The past two decades have seen an explosion in funding and research for Alzheimer's disease (AD), which has resulted in a wealth of data exploring the potential underlying processes, particularly with regard to amyloid-β (Aβ). However, to date, therapies based on this knowledge have not been forthcoming. In seeking an explanation for our current pharmacological failures, it has become clear that amyloid is only one part of a multi-factorial disease process incorporating a wealth of deleterious factors. Additionally, there is strong evidence that the initial production of Aβ is part of the evolutionarily conserved stress response, triggered by a host …of upstream factors highly altered in aging. Taken together, these observations place Aβ in a drastically different context, with toxicity occurring secondarily to upstream deleterious factors and rendering current therapeutic strategies oversimplified. This re-conceptualization necessitates a paradigm shift in our scientific and social response to AD, placing a greater emphasis on upstream interventions and public health awareness of the measures that can be taken by most individuals to reduce the risk of AD. With the increasing prevalence of AD and the realization that disease-modifying drugs may not be available in the near future, it is the responsibility of science to better communicate the worth of preventative healthcare measures to the public. Show more

Keywords: Alzheimer's disease, amyloid, health, hypoxia, metabolism, oxidative stress, public risk factors, therapeutics

DOI: 10.3233/JAD-2011-110089

Citation: Journal of Alzheimer's Disease, vol. 25, no. 4, pp. 571-581, 2011

Authors: Whitehouse, Peter J. | George, Daniel R.

Article Type: Editorial

DOI: 10.3233/JAD-2011-111020

Citation: Journal of Alzheimer's Disease, vol. 26, no. 1, pp. 1-5, 2011

Authors: George, Daniel R. | Whitehouse, Peter J.

Article Type: Book Review

DOI: 10.3233/JAD-220035

Citation: Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 509-510, 2022

Authors: Whitehouse, Peter J. | George, Daniel R.

Article Type: Book Review

DOI: 10.3233/JAD-221066

Citation: Journal of Alzheimer's Disease, vol. 90, no. 4, pp. 1831-1833, 2022

Authors: Whitehouse, Peter J. | George, Daniel R.

Article Type: Editorial

DOI: 10.3233/JAD-150663

Citation: Journal of Alzheimer's Disease, vol. 49, no. 1, pp. 21-25, 2016

Authors: Styck, Abigail C. | George, Daniel R.

Article Type: Research Article

Abstract: Background: Gardening has been shown to have positive effects on persons living with dementia, but no studies have explored the effects of gardening on sense of purpose. Objective: Explore how gardening may influence sense of purpose for people with dementia. Methods: Ten residents with dementia diagnoses living in a skilled care facility participated in hour-long gardening sessions twice weekly at outdoor raised beds over a two-month duration. One group (n  = 5) donated vegetables to a food pantry while the other (n  = 5) harvested produce for personal use. Semi-structured interviews with participants and their caregivers conducted post-intervention were analyzed for themes. …Results: Participants and caregivers reported biopsychosocial benefits of gardening, identifying four main themes: 1) Gardening outdoors provided specific physical benefits that improved quality of life; 2) Working on a project in a group setting improved mood and fostered a sense of community; 3) Gardening promoted reminiscence and reinforced a sense of self; 4) Gardening provided participants with a sense of purpose and pride. Conclusion: Gardening has biopsychosocial benefits for persons living with dementia, and there appears to be additive benefit linked to improved sense of purpose via charitable giving. Show more

Keywords: Arts, dementia, medical humanities, nature, psychosocial

DOI: 10.3233/ADR-220018

Citation: Journal of Alzheimer's Disease Reports, vol. 6, no. 1, pp. 359-367, 2022

Authors: Whitehouse, Peter J. | George, Daniel R. | D'Alton, Simon

Article Type: Research Article

DOI: 10.3233/JAD-2010-101639

Citation: Journal of Alzheimer's Disease, vol. 24, no. 1, pp. 11-13, 2011

Authors: Ballenger, Jesse | George, Daniel R. | Whitehouse, Peter J.

Article Type: Article Commentary

Abstract: In response to Finch and Burstein’s provocative argument that the advanced dementias may result from environmental toxins and lifestyle factors associated with post-industrial societies, we call for a more rigorous historical approach, emphasizing the importance of situating ancient texts more fully in their historical and cultural context. Such an approach would also entail consideration of the declining relative rates of dementia in Western countries, which have been linked to population health-level factors and policies that appear to have reduced the risk of dementia by directly and indirectly influencing the social determinants of brain health.

Keywords: Alzheimer’s disease, dementia, environmental factors, history, public health

DOI: 10.3233/JAD-240051

Citation: Journal of Alzheimer's Disease, vol. 98, no. 2, pp. 417-419, 2024