Your search for: 'author:("Dumurgier, Julien")' has returned 12 results. (0.02s) Save search

Authors: Dumurgier, Julien | Dartigues, Jean-François | Gabelle, Audrey | Paquet, Claire | Prevot, Magali | Hugon, Jacques | Tzourio, Christophe

Article Type: Research Article

Abstract: Time disorientation is commonly observed in dementia, however very little is known about the pathological significance of minor time errors in community-dwelling population. Our objective was to investigate the relationship between time orientation and risk of dementia in a population of older adults. Analyses relies on 8611 dementia-free subjects from the Three-City Study, France. Participants were followed up for 10 years for incident dementia. Time orientation was assessed by asking for the date, the day of the week, the month, the season and the year. At baseline, 905 subjects made at least one error in time orientation. During 57,073 person-years …of follow-up, 827 participants developed dementia. After controlling for age, gender and education level, subjects with one error in time had a greater risk of dementia (hazard ratio [HR] 1.44 [1.18–1.77]), while those with at least 2 errors had a more than three-fold increased risk (HR 3.10 [1.98–4.83]). This association was particularly marked for the diagnosis of probable Alzheimer’s disease. Time disorientation was associated with an increased risk of dementia in a large population of cognitively normal older people followed during up to 10 years and should not be underestimated in clinical setting. Show more

Keywords: Epidemiology, dementia, time orientation, neuropsychology, aging

DOI: 10.3233/JAD-160295

Citation: Journal of Alzheimer's Disease, vol. 53, no. 4, pp. 1411-1418, 2016

Authors: Dumurgier, Julien | Paquet, Claire | Peoc'h, Katell | Lapalus, Pauline | Mouton-Liger, François | Benisty, Sarah | Chasseigneaux, Stéphanie | Chabriat, Hughes | Hugon, Jacques

Article Type: Research Article

Abstract: Glucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in Alzheimer's disease (AD) pathogenesis. Recent evidence suggests that cerebrospinal fluid (CSF) biomarkers may reflect the brain pathology in AD. We have investigated the relationship between CSF concentrations of amyloid-β peptide 1-42 (Aβ1-42 ), total tau, and phosphorylated tau (ptau-181) and plasma and CSF glucose levels in a cohort of 94 newly diagnosed non-diabetics AD patients. We report that CSF Aβ1-42 level was inversely associated with CSF to plasma glucose ratio (Spearman's coefficient = −0.27, p = 0.008). This …relationship remained after adjustment for age, gender, body mass index, hypertension, and MMSE score (β [SE] of linear regression = −0.93 [0.37], p = 0.01). In stratified analysis, this relationship was observed only in patients who did not carry the apolipoprotein E4 allele. No significant relationship was found between glucose levels and total tau or phosphorylated tau 181. These results support the idea that a link between glucose dysmetabolism and the amyloid pathway may exist in the pathogenesis of AD. Show more

Keywords: Alzheimer's disease, amyloid-β peptide, biomarkers, CSF, glucose

DOI: 10.3233/JAD-2011-111007

Citation: Journal of Alzheimer's Disease, vol. 27, no. 4, pp. 845-851, 2011

Authors: Cressot, Coralie | Vrillon, Agathe | Lilamand, Matthieu | Francisque, Hélène | Méauzoone, Aurélie | Hourregue, Claire | Dumurgier, Julien | Marlinge, Emeline | Paquet, Claire | Cognat, Emmanuel

Article Type: Systematic Review

Abstract: Background: Psychosis, characterized by delusions and/or hallucinations, is frequently observed during the progression of Alzheimer’s disease (AD) and other neurodegenerative dementias (ND) (i.e., dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD)) and cause diagnostic and management difficulties. Objective: This review aims at presenting a concise and up-to-date overview of psychotic symptoms that occur in patients with ND with a comparative approach. Methods: A systematic review was conducted following the PRISMA guidelines. 98 original studies investigating psychosis phenotypes in neurodegenerative dementias were identified (40 cohort studies, 57 case reports). Results: Psychosis is a frequently observed phenomenon during the course of …ND, with reported prevalence ranging from 22.5% to 54.1% in AD, 55.9% to 73.9% in DLB, and 18% to 42% in FTD. Throughout all stages of these diseases, noticeable patterns emerge depending on their underlying causes. Misidentification delusions (16.6–78.3%) and visual hallucinations (50–69.6%) are frequently observed in DLB, while paranoid ideas and somatic preoccupations seem to be particularly common in AD and FTD, (respectively 9.1–60.3% and 3.10–41.5%). Limited data were found regarding psychosis in the early stages of these disorders. Conclusions: Literature data suggest that different ND are associated with noticeable variations in psychotic phenotypes, reflecting disease-specific tendencies. Further studies focusing on the early stages of these disorders are necessary to enhance our understanding of early psychotic manifestations associated with ND and help in differential diagnosis issues. Show more

Keywords: Alzheimer’s disease, delusion, dementia, dementia with Lewy bodies, frontotemporal degeneration, hallucinations, neurodegenerative disease, psychosis

DOI: 10.3233/JAD-231363

Citation: Journal of Alzheimer's Disease, vol. 99, no. 1, pp. 85-99, 2024

Authors: Gabelle, Audrey | Dumurgier, Julien | Vercruysse, Olivier | Paquet, Claire | Bombois, Stéphanie | Laplanche, Jean-Louis | Peoc'h, Katell | Schraen, Susanna | Buée, Luc | Pasquier, Florence | Hugon, Jacques | Touchon, Jacques | Lehmann, Sylvain

Article Type: Research Article

Abstract: The French Alzheimer's Disease Plan aims, in an unprecedented national effort, to develop research, promote optimal diagnosis, and take better care of patients. In order to evaluate the clinical interest and use of cerebrospinal fluid (CSF) biomarkers, a data-sharing project, the PLM (Paris-North, Lille and Montpellier) study has emerged through collaboration between these memory centers, already involved in this field. The revised Alzheimer's disease (AD) diagnosis criteria include CSF biomarkers, but little is known about their use in routine clinical practice. To evaluate their interest and diagnostic accuracy in routine AD diagnosis, a cohort of 677 patients from Montpellier was …first analyzed. The results were then validated through the analysis of a second cohort of 638 patients from Lille and Paris-Nord. Diagnoses of AD and other dementias were established by multidisciplinary expert teams, based on neuropsychological exams and structural brain imaging, blinded from CSF results. CSF amyloid-β, tau, and p-tau concentrations were measured for all patients. Receiver-operating characteristic curves were used to define cut-offs and evaluate the ability of each biomarker to discriminate AD from other diagnoses. We showed that p-tau outperformed other biomarkers for discriminating AD from non-AD patients and presents a clear clinical interest. The other biomarkers also showed relevant variations especially when the differential AD diagnoses were taken into account. Altogether we could demonstrate in both mono-centric and multi-centric cohorts from memory clinics the capacity of CSF biomarkers to discriminate AD from non-AD patients in clinical routine with a high sensitivity and specificity. Show more

Keywords: Alzheimer's disease, amyloid-β peptides, cerebrospinal fluid biomarkers, cohort studies, dementia, p-tau

DOI: 10.3233/JAD-121549

Citation: Journal of Alzheimer's Disease, vol. 34, no. 1, pp. 297-305, 2013

Authors: Foucard, Cendrine | Palisson, Juliette | Belin, Catherine | Bereaux, Chloé | Dumurgier, Julien | Paquet, Claire | Degos, Bertrand | Bouaziz-Amar, Elodie | Maillet, Didier | Houot, Marion | Garcin, Béatrice

Article Type: Research Article

Abstract: Background: The TNI-93 is a quick memory test designed for all patients regardless of their education level. A significant proportion of patients with Alzheimer’s disease (AD) are illiterate or poorly educated, and only a few memory tests are adapted for these patients. Objective: In this study we aimed at assessing the diagnostic value of the TNI-93 for diagnosis of patients with biologically confirmed amyloid status. Methods: We included all patients who had an analysis of AD cerebrospinal fluid biomarkers, a neuropsychological assessment including a TNI-93 and an anatomical brain imaging at Avicenne Hospital between January 2009 and November 2019. We …compared the TNI-93 scores in patients with amyloid abnormalities (A+) and patients without amyloid abnormalities (A-) according to the AT(N) diagnostic criteria. Results: 108 patients were included (mean age: 66.9±8.5 years old, mean education level: 8.9±5.2 years). Patients from the A + group (N= 80) were significantly more impaired than patients from the A- group (N= 28) on immediate recall (A+: 5.9±2.8; A-: 7.4±2.6; p = 0.001), free recall (A+: 3.5±2.7; A-: 5.9±2.8; p ≤ 0.001), total recall (A+: 5.7±3.5; A-:7.8±2.8; p ≤ 0.001), and on number of intrusions during the recall phase (A+: 1±1.8; A-: 0.1±0.3; p = 0.002). ROC curves revealed that the best scores to discriminate A + from A- patients were immediate recall (Area under curve (AUC): 0.70), number of encoding trials (AUC: 0.73), free recall (AUC: 0.74), and total recall (AUC: 0.74). Conclusion: The TNI-93’s immediate, free, and total recalls are valuable tools for the 39 diagnosis of AD. Show more

Keywords: Alzheimer’s disease, AT(N), cerebrospinal fluid biomarkers, illiteracy, memory test, neuropsychology

DOI: 10.3233/JAD-210546

Citation: Journal of Alzheimer's Disease, vol. 84, no. 4, pp. 1461-1471, 2021

Authors: Paquet, Claire | Bouaziz-Amar, Elodie | Cognat, Emmanuel | Volpe-Gillot, Lisette | Haddad, Victor | Mahieux, Florence | Dekimeche, Siham | Defontaines, Benedicte | Chabriat, Hugues | Belin, Catherine | Texeira, Antonio | Goutagny, Stephane | Questel, Frank | Azuar, Julien | Sellier, Pierre-Olivier | Laplanche, Jean-Louis | Hugon, Jacques | Dumurgier, Julien

Article Type: Research Article

Abstract: Background: CSF Alzheimer’s disease (AD) biomarkers allow classifying individuals based on their levels of amyloid and neurodegeneration pathologies. Objective: To investigate the distribution of AD biomarker profiles from patients suffering from cognitive disorders. Methods: We analyzed 3001 patients with cognitive disorders and referred by 18 French memory clinics located in and around Paris. Patients were classified as normal, amyloidosis (A+/N–), amyloidosis and neurodegeneration (A+/N+) or suspected non-AD pathophysiology (SNAP), according to their CSF levels of biomarkers. Analysis were performed for the overall population and stratified by gender, age quintiles, and Mini-Mental State Examination (MMSE) score quintiles. Results were compared to …previous findings in cohorts of healthy elderly adults. Results: 37% of the sample were classified as A+/N+, 22% were classified A+/N–, and 15% as SNAP. The A+/N+ profile was associated with female gender, advanced age, and lower MMSE score, while the A+/N–profile was observed more frequently in men and the distribution was stable across age and MMSE. The SNAP profile showed no association with gender or age, was less frequent in patients with lower MMSE, and had a lower repartition than the one previously reported in asymptomatic populations. Conclusions: While A+/N+ patients had the clinical characteristics typically observed in AD, A+/N–patients had a different epidemiological pattern (higher frequency in men, no association with advanced age or lower MMSE). The SNAP profile was less frequent than previously reported in the general elderly population, suggesting that this profile is not a frequent cause of memory impairment in this population. Show more

Keywords: Alzheimer’s disease, amyloid, biomarkers, cerebrospinal fluid, cohort, epidemiology, SNAP

DOI: 10.3233/JAD-180240

Citation: Journal of Alzheimer's Disease, vol. 64, no. 3, pp. 889-897, 2018

Authors: Magnin, Eloi | Paquet, Claire | Formaglio, Maité | Croisile, Bernard | Chamard, Ludivine | Miguet-Alfonsi, Carole | Tio, Gregory | Dumurgier, Julien | Roullet-Solignac, Isabelle | Sauvée, Mathilde | Thomas-Antérion, Catherine | Vighetto, Alain | Hugon, Jacques | Vandel, Pierre

Article Type: Research Article

Abstract: Background: Patients with logopenic variant of primary progressive aphasia (lvPPA) display neuropathological differences from typical amnestic Alzheimer’s disease (AD). Objective: The aim of the study was to compare cerebrospinal fluid (CSF) biomarker levels between patients with lvPPA due to AD (lvPPA-AD), non-logopenic forms of AD (nlAD), and amnestic mild cognitive impairment due to AD (aMCI-AD). Methods: CSF biomarker concentrations were assessed in 124 patients divided into three groups matched for age, level of education, center, and disease duration: lvPPA-AD (n = 30), nlAD (n = 67). and aMCI-AD (n = 27). Results: p-Tau181 levels were higher in the lvPPA-AD group …than in the aMCI-AD group (p < 0.05). Total tau levels were higher in the lvPPA-AD group versus those in the nlAD (p < 0.05) and aMCI-AD (p < 0.001) groups. Conclusions: These results suggest a more pronounced involvement of a taupathy in lvPPA-AD compared to aMCI-AD and a more important neuronal death in lvPPA-AD than in nlAD or aMCI-AD. Show more

Keywords: Alzheimer's disease, cerebrospinal fluid markers, logopenic, mild cognitive impairment, primary progressive aphasia

DOI: 10.3233/JAD-131382

Citation: Journal of Alzheimer's Disease, vol. 39, no. 3, pp. 611-616, 2014

Authors: Dumurgier, Julien | Hanseeuw, Bernard J. | Hatling, Frances B. | Judge, Kelly A. | Schultz, Aaron P. | Chhatwal, Jasmeer P. | Blacker, Deborah | Sperling, Reisa A. | Johnson, Keith A. | Hyman, Bradley T. | Gómez-Isla, Teresa

Article Type: Research Article

Abstract: Background: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer’s disease (AD) modifying therapies move toward preclinical stages. Objective: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults. Methods: 84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer’s Disease Research Center and the Harvard Aging Brain Study and followed over 3 years. Measurements of amyloid-β 1–42 (Aβ42 ), total Tau (t-Tau), and Tau phosphorylated at threonine 181 (p-Tau181) in the cerebrospinal fluid (CSF) at study entry were available …in all cases. Baseline brain MRI, FDG-PET, and PiB-PET data were available in the majority of participants. Relationship between baseline AD biomarkers and longitudinal change in cognition was assessed using Cox proportional hazard regression and linear mixed models. Results: 14% participants increased their global Clinical Dementia Rating (CDR) score from 0 to 0.5 during follow-up. A CDR score increase was associated with higher baseline CSF t-Tau and p-Tau181, higher global cortical PiB retention, and lower hippocampal volume. The combination of high CSF t-Tau and low Aβ42 or low hippocampal volume was more strongly related to cognitive outcome than each single biomarker. Higher CSF t-Tau was the only biomarker associated with subsequent decline in MMSE score. Conclusions: Baseline CSF t-Tau and p-Tau181, in vivo amyloid load, and hippocampal volume were all independently associated with future decline in cognition. The discriminatory ability of these biomarkers to predict risk of cognitive decline, however, was only modest. Show more

Keywords: Biomarkers, cognitive decline, cerebrospinal fluid, epidemiology, neuroimaging

DOI: 10.3233/JAD-170511

Citation: Journal of Alzheimer's Disease, vol. 60, no. 4, pp. 1451-1459, 2017

Authors: Morin, Alexandre | Pressat-Laffouilhere, Thibaut | Sarazin, Marie | Lagarde, Julien | Roue-Jagot, Carole | Olivieri, Pauline | Paquet, Claire | Cognat, Emmanuel | Dumurgier, Julien | Pasquier, Florence | Lebouvier, Thibaut | Ceccaldi, Matthieu | Godefroy, Olivier | Martinaud, Olivier | Grosjean, Julien | Zarea, Aline | Maltête, David | Wallon, David

Article Type: Short Communication

Abstract: This multicenter study was conducted in French memory clinics during the first COVID-2019 lockdown (March–May 2020). The objective was to evaluate the effect of a telemedicine consultation on treatment modification in dementia care. Among 874 patients who had a telemedicine consultation, 103 (10.7%) had treatment modifications, in particular those living with a relative or diagnosed with Alzheimer’s disease. A control group of patients referred March–May 2019 was also included. Treatment modification rate was similar between periods with an adjusted percentage difference of –4% (p  = 0.27). Telemedicine consultations allowed treatment modifications with only a minor short-term negative impact on therapeutic strategies.

Keywords: Alzheimer’s disease, COVID-19, psychoactive drugs, telemedicine, treatments in dementia

DOI: 10.3233/JAD-215459

Citation: Journal of Alzheimer's Disease, vol. 86, no. 2, pp. 525-530, 2022

Authors: Marelli, Cecilia | Hourregue, Claire | Gutierrez, Laure-Anne | Paquet, Claire | Menjot de Champfleur, Nicolas | De Verbizier, Delphine | Jacob, Melissa | Dubois, Jonathan | Maleska, Aleksandra Maceski | Hirtz, Christophe | Navucet, Sophie | Bennys, Karim | Dumurgier, Julien | Cognat, Emmanuel | Berr, Claudine | Magnin, Eloi | Lehmann, Sylvain | Gabelle, Audrey

Article Type: Research Article

Abstract: Background: Memory troubles and hippocampal atrophy are considered more frequent and focal atrophy less severe in late-onset (>65 years) than in presenile behavioral variant of frontotemporal dementia (bvFTD). Objective: To compare cerebrospinal fluid (CSF) and plasma biomarkers in late-onset and presenile bvFTD. Methods: Multicentric retrospective study (2007-2017) on patients with clinical diagnosis of bvFTD. Results: This study included 44 patients (67%) with presenile and 22 (33%) with late-onset bvFTD (comparable mean disease duration; n  = 11 with causal mutations). Hippocampal atrophy was more frequent (80% versus 25.8%) and severe in late-onset bvFTD (median Scheltens score: 3 [0–4] versus 1 [0–3]), without …difference after adjustment for age. Lobar atrophy and focal hypometabolism/hypoperfusion were not different between groups. The median CSF Aβ1-42 and phosphorylated tau (P-tau) concentrations were in the normal range and comparable between groups. Axonal neurodegeneration biomarkers were within the normal range (CSF T-tau; plasma T-tau in late-onset bvFTD) or higher (plasma neurofilament light chain (NFL); plasma T-tau in presenile bvFTD) than the normal values, but globally not different between bvFTD groups. Plasma glial fibrillary acid protein (GFAP) was strongly increased in both bvFTD groups compared with the values in controls of the same age. Conclusion: The CSF and plasma biomarker profiles did not suggest a more aggressive neurodegeneration in the presenile group (comparable T-tau, NFL, and GFAP levels) or the co-existence of Alzheimer’s disease in the late-onset group (comparable and within normal range CSF Aβ1-42 and P-tau). The severity of the neurodegenerative process seems comparable in presenile and late-onset bvFTD. Show more

Keywords: Biomarkers, cerebrospinal fluid, frontotemporal dementia, glial fibrillary acid protein, late-onset, neurofilament light chain

DOI: 10.3233/JAD-190378

Citation: Journal of Alzheimer's Disease, vol. 74, no. 3, pp. 903-911, 2020