Your search for: 'author:("Bennett, David A.")' has returned 48 results. (0.014s) Save search

Authors: Yu, Lei | Mottola, Gary | Bennett, David A. | Boyle, Patricia A.

Article Type: Research Article

Abstract: Background: Financial and health literacy are associated with cognitive outcomes in old age. However, the extent to which confidence in financial and health literacy is related to cognitive health is unknown. Objective: This study tests the hypothesis that confidence is associated with cognitive outcomes above and beyond actual financial and health literacy. Methods: A total of 974 older adults underwent assessments of literacy and confidence in literacy, and were subsequently followed for annual clinical evaluations. Financial and health literacy were assessed via a series of items which were immediately followed by questions asking participants to rate their confidence in accuracy …of their response to the literacy items. Cox proportional hazards models examined the associations of financial and health literacy and confidence in literacy with incident Alzheimer’s disease (AD) dementia; and linear mixed models examined the associations with cognitive decline. Results: Participants on average were 81.2 years of age at literacy assessment. Over up to 9 years of annual follow-up, 175 (18%) developed AD dementia. After adjusting for demographics, higher confidence in financial literacy was associated with lower risk of AD dementia and slower decline in cognition. The results persisted after further adjusting for financial literacy performance. Similar findings were observed for confidence in health literacy. Further, older adults who expressed under-confidence relative to their actual level of financial and health literacy were more likely to develop AD dementia and experienced faster cognitive decline. Conclusion: Both domain-specific literacy and confidence in one’s financial and health knowledge are important determinants of cognitive health among community-dwelling older adults. Show more

Keywords: Alzheimer’s disease, cognition, confidence, heath and financial literacy

DOI: 10.3233/JAD-200001

Citation: Journal of Alzheimer's Disease, vol. 75, no. 4, pp. 1229-1240, 2020

Authors: Huang, Jeffrey Y. | Hafez, Daniel M. | James, Bryan D. | Bennett, David A. | Marr, Robert A.

Article Type: Research Article

Abstract: Neprilysin-2 (NEP2), a close homolog of neprilysin (NEP), degrades amyloid-β (Aβ) and serves an important role in clearing Aβ in vivo. We measured NEP2 and NEP mRNA levels from non-impaired (NI), mild cognitive impaired (MCI), and clinical Alzheimer's disease (AD) subjects in the mid-temporal gyrus, mid-frontal gyrus, caudate, and cerebellum. NEP2 activity levels were also determined. Our results indicate that NEP2 and NEP mRNA expression is altered in MCI subjects relative to NI subjects in AD-susceptible regions. NEP2 enzymatic activity was lowered in association with MCI and AD and was positively associated with cognitive function, independent of diagnostic category. Our …finding that NEP2 expression and activity are altered in MCI is significant as these changes may potentially serve as preclinical markers for AD and reduced NEP2 activity may be associated with the development of AD. Show more

Keywords: Alzheimer's disease, amyloid-β peptide, biomarker, human brain, neprilysin, neprilysin-2

DOI: 10.3233/JAD-2011-111307

Citation: Journal of Alzheimer's Disease, vol. 28, no. 2, pp. 433-441, 2012

Authors: Schneider, Julie A. | Aggarwal, Neelum T. | Barnes, Lisa | Boyle, Patricia | Bennett, David A.

Article Type: Research Article

Abstract: Community-based cohorts of older persons may differ neuropathologically from clinic-based cohorts. This study investigated age-related pathologies in persons with and without dementia and included autopsied participants from two community-based cohorts, the Rush Religious Orders Study (n=386) and the Memory and Aging Project (n=195), and one clinic-based cohort, the Clinical Core of the Rush Alzheimer's Disease Center (n=392). Final clinical diagnoses included no cognitive impairment (n=202), mild cognitive impairment (MCI) (n=150), probable Alzheimer's disease (AD) (n=474), possible AD (n=88), and other dementias (n=59). Postmortem diagnoses included pathologic AD, cerebral infarcts, and Lewy body disease. Community-based persons with clinical AD had less …severe AD pathology (p<0.001) and had more cerebral infarcts (p<0.001) compared to clinic-based persons. Additionally, community-based persons with MCI had more infarcts compared to clinic-based persons. Overall, there was a higher proportion of Lewy bodies and atypical pathologies in the clinic-based compared to the community-based cohorts (p<0.001). Community-based persons with probable AD show less severe AD pathology and more often have infarcts and mixed pathologies; those with MCI more often have infarcts and mixed pathologies. Overall, clinic-based persons have more Lewy bodies and atypical pathologies. The spectrum of pathologies underlying cognitive impairment in clinic-based cohorts differs from community-based cohorts. Show more

Keywords: Clinic, community, epidemiology, neuropathology, selection bias

DOI: 10.3233/JAD-2009-1227

Citation: Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 691-701, 2009

Authors: Bienias, Julia L. | Beckett, Laurel A. | Bennett, David A. | Wilson, Robert S. | Evans, Denis A.

Article Type: Research Article

Abstract: The design of the Chicago Health and Aging Project (CHAP) is described. CHAP is a longitudinal population study of common chronic health problems of older persons, especially of risk factors for incident Alzheimer's disease, in a biracial neighborhood of the south side of Chicago. Special attention is given to three unusual design features of the study. One feature is that clinical evaluation for Alzheimer's disease is confined to a stratified random sample of all participants. This feature results in substantial cost savings and substantially less bias than screening approaches but has the disadvantages of adding analytic complexity and requiring the …use of indirect means to identify a disease-free cohort for the development of incident Alzheimer's disease. The second unusual feature is efficiently combining in analyses the successive independent multiple samples that are drawn, one from each data collection cycle. The third unusual feature is entering successive age cohorts of community residents into the study as they attain 65 years of age. This has the advantages of enhancing direct investigation of the effect of age on the action of risk factors for Alzheimer's disease and direct examination of cohort effects. The interaction of these features is described, especially as they pertain to a study in which data are collected in successive waves. The results from these waves must be combined for effective analysis of the relation among risk factors and incident disease. Show more

Keywords: aging, Alzheimer's disease, longitudinal study, community study, random sampling

DOI: 10.3233/JAD-2003-5501

Citation: Journal of Alzheimer's Disease, vol. 5, no. 5, pp. 349-355, 2003

Authors: Tremblay, Cyntia | Pilote, Mireille | Phivilay, Alix | Emond, Vincent | Bennett, David A. | Calon, Frédéric

Article Type: Research Article

Abstract: We report a post mortem biochemical analysis of amyloid-β (Aβ) (ELISA) and tau (Western immunoblots) in the temporo-parietal neocortex of subjects with a clinical diagnosis of mild cognitive impairment (MCI, n = 12 ), Alzheimer's disease (AD, n = 12 ) or no cognitive impairment (NCI, n = 12 ). Levels of Aβ42 in the detergent-insoluble protein fractions were significantly higher in persons with AD but did not differentiate individuals with MCI. Conversion of tau into its insoluble form (soluble/insoluble tau ratio) or into paired helical filament tau (PHFtau ) were the biochemical variables most closely related to clinical and …neuropathological diagnoses, but they did not distinguished MCI from the two other groups. Interestingly, soluble/insoluble total tau ratio, PHFtau and insoluble Aβ42 concentrations in the cortex correlated strongly with global cognition scores proximate to death and with immunohistochemical and histological quantification of Aβ and tau pathologies. Our data suggest that 1) insoluble Aβ42 and insoluble tau (total or PHFtau ) show a significant relationship with the clinical and neuropathological diagnosis of AD; 2) Although MCI appears to represent an intermediate stage between NCI and AD, the quantification of cortical Aβ and tau pathologies did not significantly distinguish subjects with MCI from either group. Show more

Keywords: Mild cognitive impairment, Alzheimer's disease, amyloid-β, tau, paired helical filament tau, postmortem, brain cortex, western immunoblotting, Elisa

DOI: 10.3233/JAD-2007-12411

Citation: Journal of Alzheimer's Disease, vol. 12, no. 4, pp. 377-390, 2007

Authors: Shah, Raj C. | Schneider, Julie A. | Leurgans, Sue | Bennett, David A.

Article Type: Review Article

Abstract: Lower hemoglobin levels have been associated with cognitive decline in older persons. The objective of this study was to investigate the relationship between lower hemoglobin levels and common, age-related neuropathologies associated with cognitive decline. Hemoglobin and neuropathology measures were available in 113 deceased, community-dwelling, older adults participating in the Rush Memory and Aging Project, a prospective, observational, clinical pathology study of aging. The mean hemoglobin level was 13.0 g/dL (SD = 1.4) and was measured 3.2 (SD = 1.3) years prior to death. Thirty-five participants had at least one chronic macroscopic infarction and twenty-nine had at least one chronic microscopic …infarction. Eleven participants had Lewy Bodies. The mean Alzheimer's disease pathology score based on a summary measure of neuritic plaques, diffuse plaques, and neurofibrillary tangles was 0.56 unit (SD = 0.56; range = 0, 2.34). Using logistic regression models adjusted for age at death, gender, and education, each g/dL lower hemoglobin level increased the odds for having a chronic macroscopic infarction by 37% (95% CI = 1.01, 1.86) but not for having a chronic microscopic infarction (OR = 1.11; 95% CI = 0.82, 1.52) or Lewy Bodies (OR = 1.07; 95% CI = 0.68, 1.68). In an adjusted multiple regression model, hemoglobin level was not associated with the global AD pathology measure (parameter estimate = −0.02, SE = 0.03, p = 0.6). In secondary analyses, lower hemoglobin levels were associated with higher odds of having a chronic macroscopic infarction in a subcortical region but not with higher total subcortical chronic macroscopic infarction volume. In conclusion, lower hemoglobin levels appear to be associated with chronic macroscopic infarctions but not other common age-related neuropathologies. Show more

Keywords: Diffuse plaque, hemoglobin, macroscopic infarction, Lewy body, microscopic infarction, neuritic plaque, neurofibrillary tangle, neuropathology

DOI: 10.3233/JAD-2012-120952

Citation: Journal of Alzheimer's Disease, vol. 32, no. 3, pp. 579-586, 2012

Authors: Pandey, Janardan P. | Namboodiri, Aryan M. | Nietert, Paul J. | Barnes, Lisa L. | Bennett, David A.

Article Type: Short Communication

Abstract: We investigated whether FCGRIIB (rs1050501 C/T) and PILRA (rs1859788 A/G) genotypes contributed to the development of Alzheimer’s disease (AD). We genotyped 209 African American (AA) and 638 European American (EA) participants for the FCGRIIB and PILRA alleles. In the AA cohort, subjects homozygous for the C allele of FCGRIIB were more than 4 times as likely to develop AD as those homozygous for the alternative T allele. This SNP also interacted with PILRA : participants who were the carriers of the FCGRIIB C allele and PILRA A allele were 3 times as likely to develop AD as those who lacked …these alleles. Show more

Keywords: Amyloid-β, FCGRIIB, neurotoxicity, PILRA

DOI: 10.3233/JAD-215174

Citation: Journal of Alzheimer's Disease, vol. 84, no. 3, pp. 965-968, 2021

Authors: Beckers, Elise | Riphagen, Joost M. | Van Egroo, Maxime | Bennett, David A. | Jacobs, Heidi I.L.

Article Type: Short Communication

Abstract:  Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer’s disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.

Keywords: Alzheimer’s disease, asymmetry, autopsy, brainstem, locus coeruleus, neurons, tangles

DOI: 10.3233/JAD-231328

Citation: Journal of Alzheimer's Disease, vol. 99, no. 1, pp. 105-111, 2024

Authors: Han, S. Duke | Boyle, Patricia A. | James, Bryan D. | Yu, Lei | Bennett, David A.

Article Type: Research Article

Abstract: Background: Falling victim to financial scams can have a significant impact upon social and financial wellbeing and independence. A large proportion of scam victims are older adults, but whether older victims with mild cognitive impairment (MCI) are at higher risk remains unknown. Objective: We tested the hypothesis that older persons with MCI exhibit greater susceptibility to scams compared to those without cognitive impairment. Methods: Seven hundred and thirty older adults without dementia were recruited from the Rush Memory and Aging Project, a community-based epidemiologic study of aging. Participants completed a five-item self-report measure of susceptibility to scams, a battery of …cognitive measures, and clinical diagnostic evaluations. Results: In models adjusted for age, education, and gender, the presence of MCI was associated with greater susceptibility to scams (B  = 0.125, SE = 0.063, p -value = 0.047). Further, in analyses of the role of specific cognitive systems in susceptibility to scams among persons with MCI (n  = 144), the level of performance in two systems, episodic memory and perceptual speed abilities, were associated with susceptibility. Conclusions: Adults with MCI may be more susceptible to scams in old age than older persons with normal cognition. Lower abilities in specific cognitive systems, particularly perceptual speed and episodic memory, may contribute to greater susceptibility to scams in those with MCI. Show more

Keywords: Cognition, episodic memory, mild cognitive impairment, processing speed, scam

DOI: 10.3233/JAD-150442

Citation: Journal of Alzheimer's Disease, vol. 49, no. 3, pp. 845-851, 2016

Authors: Yu, Lei | Wilson, Robert S. | Schneider, Julie A. | Bennett, David A. | Boyle, Patricia A.

Article Type: Research Article

Abstract: Background: Domain specific literacy is a multidimensional construct that requires multiple resources including cognitive and non-cognitive factors. Objective: We test the hypothesis that domain specific literacy is associated with Alzheimer’s disease (AD) dementia and AD pathology after controlling for cognition. Methods: Participants were community-based older persons who completed a baseline literacy assessment, underwent annual clinical evaluations for up to 8 years, and agreed to organ donation after death. Financial and health literacy was measured using 32 questions and cognition was measured using 19 tests. Annual diagnosis of AD dementia followed standard criteria. AD pathology was examined postmortem by quantifying plaques …and tangles. Cox models examined the association of literacy with incident AD dementia. Performance of model prediction for incident AD dementia was assessed using indices for integrated discrimination improvement and continuous net reclassification improvement. Linear regression models examined the independent association of literacy with AD pathology in autopsied participants. Results: All 805 participants were free of dementia at baseline and 102 (12.7%) developed AD dementia during the follow-up. Lower literacy was associated with higher risk for incident AD dementia (p  < 0.001), and the association persisted after controlling for cognition (hazard ratio = 1.50, p  = 0.004). The model including the literacy measure had better predictive performance than the one with demographics and cognition only. Lower literacy also was associated with higher burden of AD pathology after controlling for cognition (β= 0.07, p  = 0.035). Conclusion: Literacy predicts incident AD dementia and AD pathology in community-dwelling older persons, and the association is independent of traditional measures of cognition. Show more

Keywords: Alzheimer’s disease, cognition, dementia, domain specific literacy, pathology

DOI: 10.3233/JAD-161132

Citation: Journal of Alzheimer's Disease, vol. 56, no. 4, pp. 1485-1493, 2017