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KATSUYOSHI SEKI, KOICHI KATO, KATSUJI SHIMA, Parallelism in the Luteinizing Hormone Responses to Opioid and Dopamine Antagonists in Hyperprolactinemic Women with Pituitary Microadenoma, The Journal of Clinical Endocrinology & Metabolism, Volume 63, Issue 5, 1 November 1986, Pages 1225–1228, https://doi.org/10.1210/jcem-63-5-1225
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Abstract
Endogenous opiate peptides are considered to inhibit LH secretion via a dopaminergic mechanism, and increased opioid inhibition of LH secretion has been found in some hyperprolactinemic women with a pituitary microadenoma. To assess the role of endogenous dopaminergic tone in the opioidregulation of LH secretion in such patients, LH responses to an opioid antagonist (naloxone) and a dopamine antagonist (metoclopramide) were determined in 11 women with a prolactinoma. Neither naloxone nor metoclopramide administration induced any change in serum LH levels in normal women during the early follicular phase. In contrast, 7 of the 11 hyperprolactinemic women responded to both antagonists with a significant increase in LH levels. The parallelism in the LH responses to both antagonists in these hyperprolactinemic patients lends further support to a functional link between opioid and dopamine regulation of LH secretion.