eCompendia
Digital Collections (Previously eCompendia)
- Weight Loss and Bone
- Osteoporosis: The Treatment Gap
- ASBMR 2016 Annual Meeting Featured Articles
- Bone and the Nervous System
- Rare Bone Diseases
- Selected Altmetric Articles
- Genetics and Osteoporosis
- Muscle and Bone
- Kidney Disease and Bone
- Sclerostin: Preclinical and Clinical Studies
- Genetics of Osteogenesis Imperfecta
- Exercise and Bone Health in Children and Young Adults
- Obesity, Fat and Bone
- Stem Cells
- Male Osteoporosis
- Atypical Femoral Fractures
- Raisz-Drezner First Paper Award Winners 2008-2014
- Osteoporosis Treatment
- JBMR Classics
- Top 10 Downloads
- Parathyroid Hormone (PTH) Articles
- Vitamin D Articles 2009 - Present
- Basic Research Perspectives
- Clinical Perspectives
eCompendia bring together recently published JBMR® articles on topical issues. Specific topics are selected for each eCompendium to provide the reader with an easy-to-access update that brings together original research articles in the chosen area.
Examples of topics addressed in recent eCompendia include Kidney Disease and Bone, Sclerostin: Preclinical and Clinical Studies and Genetics of Osteogenesis Imperfecta.
Weight Loss and Bone
Fracture Risk After Bariatric Surgery: Roux-en-Y Gastric Bypass Versus Adjustable Gastric Banding
Elaine W Yu et al.
Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status
Anne L Schafer et al.
Assessment of Sex Differences in Fracture Risk Among Patients With Anorexia Nervosa: A Population-Based Cohort Study Using The Health Improvement Network
Jason M Nagata et al.
Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women
Katherine N Bachmann et al.
Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial
Dennis T Villareal et al. and for the CALERIE Study Group
Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials
Jessica Zibellini et al.
Decline in Bone Mass During Weight Loss: A Cause for Concern?
Anne L Schafer
Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women
Juliet E Compston et al.
Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice
Ann-Kathrin Behrendt et al.
Osteoporosis: The Treatment Gap
Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study
Jose Leal et al.
Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis
Samuel Hawley et al. for the REFReSH Study Group
A Crisis in the Treatment of Osteoporosis
Sundeep Khosla, Elizabeth Shane
Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward
Sundeep Khosla et al.
Impact of the U.S. Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates After Hip Fracture
Seoyoung C Kim et al.
Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996-2012: An Ecological Analysis
Smita Jha et al.
Overdiagnosis and Overtreatment of Osteoporosis: A Wolf in Sheep's Clothing
Michael R McClung
Osteoporosis Medication use After hip Fracture in U.S. Patients Between 2002 and 2011
Daniel H Solomon et al.
The Osteoporosis Treatment Gap
John A Kanis et al.
The Potential Economic Benefits of Improved Postfracture Care: A Cost-Effectiveness Analysis of a Fracture Liaison Service in the US Health-Care System
Daniel H Solomon et al.
ASBMR 2016 Annual Meeting Featured Articles
MiR-503 Regulates Osteoclastogenesis via Targeting RANK
Chao Chen et al.
Female Mice Lacking Estrogen Receptor-Alpha in Osteoblasts Have Compromised Bone Mass and Strength
Katherine M Melville et al.
microRNA-103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2
Bin Zuo et al.
Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
Claudine Seeliger et al.
Denosumab Rapidly Increases Cortical Bone in Key Locations of the Femur: A 3D Bone Mapping Study in Women With Osteoporosis
Kenneth ES Poole et al.
How Tough Is Brittle Bone? Investigating Osteogenesis Imperfecta in Mouse Bone
Alessandra Carriero et al.
In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes
Joshua N Farr et al.
Cortical Porosity Identifies Women With Osteopenia at Increased Risk for Forearm Fractures
Yohann Bala et al.
The Effects of Calcium Supplementation on Verified Coronary Heart Disease Hospitalization and Death in Postmenopausal Women: A Collaborative Meta-Analysis of Randomized Controlled Trials
Joshua R Lewis et al.
Bone and the Nervous System
Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights
Beata Lecka-Czernik and Clifford J Rosen
Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System
Guillaume Vignaux et al.
Obstructive Sleep Apnea and Metabolic Bone Disease: Insights Into the Relationship Between Bone and Sleep
Christine M Swanson et al.
Major Depressive Disorder and Bone Mass in Adolescents and Young Adults
Chadi A Calarge et al.
Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits
PA Baldock et al.
Bone remodeling is regulated by inner ear vestibular signals
Guillaume Vignaux et al.
Altered Thermogenesis and Impaired Bone Remodeling in Misty Mice
Katherine J Motyl et al.
Neuropeptide Y Is a Critical Modulator of Leptin's Regulation of Cortical Bone
Iris PL Wong et al.
Rare Bone Diseases
Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis
Michael P Whyte et al.
Sclerostin Deficiency Is Linked to Altered Bone Composition
Norbert Hassler et al.
Osteoporosis Caused by Mutations in PLS3: Clinical and Bone Tissue Characteristics
Somayyeh Fahiminiya et al.
Clinical and Radiographic Findings in Adults With Persistent Hypophosphatasemia
Fergus Eoin McKiernan et al.
Panostotic Expansile Bone Disease With Massive Jaw Tumor Formation and a Novel Mutation in the Signal Peptide of RANK
Anne L Schafer et al.
Lenz-Majewski Hyperostotic Dwarfism with Hyperphosphoserinuria from a Novel Mutation in PTDSS1 Encoding Phosphatidylserine Synthase 1
Michael P Whyte et al.
Atypical Femoral Fracture in Osteoporosis Pseudoglioma Syndrome Associated with Two Novel Compound Heterozygous Mutations in LRP5
Nerea Alonso et al.
Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and FBN1 Genotype
Elsa Haine et al.
Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23–related hypophosphatemia, dental anomalies, and ectopic calcification
Silje Hjorth Rafaelsen MD et al.
Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65)
Anja L Frederiksen et al.
Selected Altmetric Articles
In this eCompendium we highlight the most “attention-getting” recent JBMR articles. Following are the articles getting the most print and online buzz including press releases and social media channels like Facebook and Twitter as gathered by Altmetrics.
Bone Strength and Structural Deficits in Children and Adolescents With a Distal Forearm Fracture Resulting From Mild Trauma
Joshua N Farr et al.
Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
Leonardo Mellibovsky et al.
Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry
Scott M Smith et al.
Developmental Dysplasia of the Hip: Linkage Mapping and Whole Exome Sequencing Identify a Shared Variant in CX3CR1 in All Affected Members of a Large Multigeneration Family
George J Feldman et al.
Architecture of the osteocyte network correlates with bone material quality
Michael Kerschnitzki et al.
Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness
Bruce W Hollis et al.
Childhood Bone Mineral Content Is Associated With Methylation Status of the RXRA Promoter at Birth
Nicholas C Harvey et al.
Reduction in Proximal Femoral Strength in Patients With Acute Spinal Cord Injury
W Brent Edwards et al.
Life Expectancy in Patients Treated for Osteoporosis: Observational Cohort Study Using National Danish Prescription Data
Bo Abrahamsen et al.
The Influence of High-Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention
Sarah J Allison et al.
Trends in Media Reports, Oral Bisphosphonate Prescriptions, and Hip Fractures 1996–2012: An Ecological Analysis
Smita Jha et al.
Genetics and Osteoporosis
Assessment of gene-by-sex interaction effect on bone mineral density
Ching-Ti Liu et al.
Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS)
Alireza Moayyeri et al.
Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density
Tie-Lin Yang et al.
Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
Daniel L Koller et al.
Osteoporosis Caused by Mutations in PLS3: Clinical and Bone Tissue Characteristics
Somayyeh Fahiminiya et al.
A Novel Splice Mutation in PLS3 Causes X-linked Early Onset Low-Turnover Osteoporosis
Christine M Laine et al.
Susceptibility genes for osteoporotic fracture in postmenopausal chinese women
Chun Wang et al.
Evidence for a genetic link between bone and vascular measures in African ancestry families
Allison L Kuipers et al.
Analyses of RANK and RANKL in the Post-GWAS Context: Functional Evidence of Vitamin D Stimulation Through a RANKL Distal Region
Guy Yoskovitz et al.
Muscle and Bone
Bone and Skeletal Muscle: Neighbors With Close Ties
Douglas J DiGirolamo et al.
Forum on bone and skeletal muscle interactions: Summary of the proceedings of an ASBMR workshop
Lynda F Bonewald et al.
Pamidronate Attenuates Muscle Loss After Pediatric Burn Injury .
Elisabet Børsheim et al.
Muscle Size, Strength, and Physical Performance and Their Associations With Bone Structure in the Hertfordshire Cohort Study
Mark H Edwards et al.
Dairy Food Intake, Peripheral Bone Structure, and Muscle Mass in Elderly Ambulatory Women
Simone Radavelli-Bagatini et al.
Impaired Bone Microarchitecture at the Distal Radius in Older Men With Low Muscle Mass and Grip Strength: The STRAMBO Study
Pawel Szulc et al.
Childhood Cortical Porosity Is Related to Microstructural Properties of the Bone-Muscle Junction
Christine M Schnitzler
METTL21C Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-kappa B Signaling Pathway
Jian Huang et al.
Interdependence of Muscle Atrophy and Bone Loss Induced by Mechanical Unloading
Shane A Lloyd et al.
Delayed Bone Regeneration Is Linked to Chronic Inflammation in Murine Muscular Dystrophy .
Rana Abou-Khalil1 et al.
Botulinum Toxin Induces Muscle Paralysis and Inhibits Bone Regeneration in Zebrafish .
Anthony M Recidoro et al.
Kidney Disease and Bone
Rapid cortical bone loss in patients with chronic kidney disease
Thomas L Nickolas et al.
Renal safety in patients treated with bisphosphonates for osteoporosis: A review
Paul D Miller et al.
Cardiovascular and renal complications to postsurgical hypoparathyroidism: A Danish nationwide controlled historic follow-up study
Line Underbjerg et al.
Osteogenesis of Heterotopically Transplanted Mesenchymal Stromal Cells in Rat Models of Chronic Kidney Disease
Rafael Kramann et al.
A single-dose study of denosumab in patients with various degrees of renal impairment
Geoffrey A Block et al.
Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease
Jason R Stubbs et al.
The Impact of Acute Kidney Injury With Temporary Dialysis on the Risk of Fracture
Wei-Jie Wang et al. and the National Taiwan University Study Group on Acute Renal Failure
A Comparison of Calcium to Zoledronic Acid for Improvement of Cortical Bone in an Animal Model of CKD
Sharon M Moe et al.
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy
Yves Sabbagh et al.
Role of TGF- beta in a Mouse Model of High Turnover Renal Osteodystrophy
Liu, Shiguang et al.
Sclerostin: Preclinical and Clinical Implications
Preclinical
Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2
Masakazu Kogawa et al.
Sclerostin antibody stimulates bone regeneration after experimental periodontitis
Andrei D Taut et al.
Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
Jordan M Spatz et al.
Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels
Sandra Jastrzebski et al.
Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus
Christine Hamann et al.
Clinical
High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study
Mohammed-Salleh M Ardawi et al.
Sclerostin and bone strength in women in their 10th decade of life
Sara Thorson et al.
Correlates of bone microarchitectural parameters and serum sclerostin levels in men: The STRAMBO study
Pawel Szulc et al.
Lower fracture risk in older men with higher sclerostin concentration: A prospective analysis from the MINOS study
Pawel Szulc et al.
Reversing LRP5-Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
Ming-Kang Chang et al.
Genetics of Osteogenesis Imperfecta
A non-classical IFITM5 mutation located in the coding region causes severe Osteogenesis imperfecta with prenatal onset
Heike Hoyer-Kuhn
Osteogenesis imperfecta without features of type V caused by a mutation in the IFITM5 gene
Monica Grover
A mouse model for human osteogenesis imperfecta type VI
Thomas Clemens
Phenotypic variability of Osteogenesis Imperfecta type V caused by an IFITM5 mutation
Philippe Campeau
Skeletal Clinical Characteristics of Osteogenesis Imperfecta Caused by Haploinsufficiency Mutations in COL1A1
I mouna ben amor
Sclerostin Antibody Improves Skeletal Parameters in a Brtl/ Mouse Model of Osteogenesis Imperfecta
Ken Kozloff
First Mouse Model for Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome
Frieda Chen
Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta
Christina Jacobsen
Exercise and Bone Health in Children and Young Adults
Bone mineral accrual in 4- to 10-year-old precompetitive, recreational gymnasts: A 4-year longitudinal study
Marta C Erlandson et al.
Effects of repetitive loading on the growth-induced changes in bone mass and cortical bone geometry: A 12-month study in pre/peri- and postmenarcheal tennis players
Gaele Ducher et al.
Influence of a 3-year exercise intervention program on fracture risk, bone mass, and bone size in prepubertal children
Bjarne Löfgren et al.
High-frequency, low-intensity vibrations increase bone mass and muscle strength in upper limbs, improving autonomy in disabled children
M Loreto Reyes et al.
Higher premenarcheal bone mass in elite gymnasts is maintained into young adulthood after long-term retirement from sport: A 14-year follow-up
Marta C Erlandson et al.
Increased physical activity is associated with enhanced development of peak bone mass in men: A five-year longitudinal study
Martin Nilsson et al.
Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: Results from a population-based study of adolescents
Kevin Deere et al.
Former premenarcheal gymnasts exhibit site-specific skeletal benefits in adulthood after long-term retirement
Marta C Erlandson et al.
Obesity, Fat and bone
BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)
Carrie M Nielson et al.
Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women
Miranda EG Armstrong et al. for the Million Women Study Collaborators
Adipokines and the risk of fracture in older adults
Kamil E Barbour et al.
Leptin's balancing act between bone and fat
Jeffrey M Gimble
Obesity and fracture in men and women: An epidemiologic perspective
Carrie M Nielson et al.
The association between fracture and obesity is site-dependent: A population-based study in postmenopausal women
Daniel Prieto-Alhambra et al.
Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: Results from the look AHEAD randomized trial
Ann V Schwartz et al.
Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training
Reina Armamento-Villareal et al.
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Helena Johansson et al.
Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats
Urszula T Iwaniec et al.
Type 2 diabetes and bone
William D Leslie, Mishaela R Rubin, Ann V Schwartz and John A Kanis
Stem Cells
The editorial team at JBMR is pleased to present a new eCompendium on stem cells. eCompendia (formerly known as virtual issues) are online-only collections of previously published materials in which the editor highlights important topics relevant to bone and mineral research. With this issue on stem cells and future volumes, we intend to showcase selected papers of importance and interest to JBMR's readership. Check back later in 2013 for our next installment!
Clinical characteristics influence in vitro action of 1,25-dihydroxyvitamin D3 in human marrow stromal cells
Shuanhu Zhou et al.
Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity
Danielle E Green et al.
Bone density and structure in long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation
Sogol Mostoufi-Moab et al.
BMPs
Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling
Bing Yu et al.
Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells
Enyi Huang et al.
Heterotopic ossification
The role of endothelial-mesenchymal transition in heterotopic ossification
Damian Medici and Bjorn R Olsen
Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification
Michael N Wosczyna et al.
Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
Robert J Pignolo, Meiqi Xu, Elizabeth Russell, Alec Richardson, Josef Kaplan, Paul C Billings, Frederick S Kaplan and Eileen M Shore
Endochondral ossification
Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing
Do Y Soung et al.
The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation
Rachel Grimes et al.
Wnt/Beta-catenin
WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production
Martina Rauner et al.
Male Osteoporosis
2011
Regulation of circulating sclerostin levels by sex steroids in women and in men
Ulrike IL Mödder et al.
Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: A population-based HR-pQCT study
Heather M Macdonald et al.
Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: The osteoporotic fractures in men (MrOS) study
Yahtyng Sheu et al.
Relation of age, gender, and bone mass to circulating sclerostin levels in women and men
Ulrike I Mödder et al.
BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)
Carrie M Nielson et al. for the Osteoporotic Fractures in Men Study (MrOS) Research Group
Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study
Claes Ohlsson et al.
Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: The STRAMBO study
Pawel Szulc et al.
Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis
Janina M Patsch et al.
Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS
M Kassim Javaid, et al. for the Osteoporotic Fractures in Men (MrOS) Research Group
2012
Prediction of fracture risk in men: A cohort study
Liisa Byberg et al.
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Helena Johansson et al.
Change in hip bone mineral density and risk of subsequent fractures in older men
Peggy M Cawthon et al. for the Osteoporotic Fractures in Men (MrOS) Research Group
The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: The osteoporotic fractures in men (MrOS) study
Elizabeth Barrett-Connor et al. for the Osteoporotic Fractures in Men (MrOS) Research Group
Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study
Lang Yang et al. for the Osteoporotic Fractures in Men (MrOS) Study Group
Atypical Femoral Fractures
Trends in Incidence of Subtrochanteric Fragility Fractures and Bisphosphonate Use Among the US Elderly, 1996–2007
Zhong Wang and Timothy Bhattacharyya
Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort
Seo Young Kim et al.
Subtrochanteric/femoral shaft versus hip fractures: Incidences and identification of risk factors
Milka Maravic et al.
Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures
Eve Donnelly et al.
Atypical femur fractures: Refining the clinical picture
Bo Abrahamsen
Incidence and demography of femur fractures with and without atypical features
Adrianne C Feldstein et al.
“Atypical femoral fractures” during bisphosphonate exposure in adult hypophosphatasia
Roger AL Sutton et al.
Low-energy fractures of the humeral shaft and bisphosphonate use
Maria P Yavropoulou et al.
Incidence of atypical nontraumatic diaphyseal fractures of the femur
Richard M Dell et al.
Raisz-Drezner First Paper Award Winners 2008-2014
2014
Fracture Risk Predictions Based on Statistical Shape and Density Modeling of the Proximal Femur
Todd Bredbenner, Ph.D
2013
Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development
Takamitsu Maruyama et al.
Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model
Steven D. Rhodes et al.
2012
Mutations in SERPINF1 cause osteogenesis imperfecta type VI
Erica P Homan et al.
Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
Glenn C Rowe, et al.
2011
Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment
Hamid Saeed et al.
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
Kylie A Alexander et al.
2010
Fracture healing is accelerated in the absence of the adaptive immune system
Daniel Toben et al.
2009
2008
Functional Adaptation to Loading of a Single Bone Is Neuronally Regulated and Involves Multiple Bones
Susannah J Sample et al.
Bone Morphometry Strongly Predicts Cortical Bone Stiffness and Strength, but Not Toughness, in Inbred Mouse Models of High and Low Bone Mass
Romain Voide et al.
Osteoporosis Treatment
Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis
Michael R McClung et al.
Long-term impact of adherence to oral bisphosphonates on osteoporotic fracture incidence
John S Sampalis et al.
FRAX underestimates fracture risk in patients with diabetes
Lora M Giangregorio et al.
The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
Dennis M Black et al.
Effects of antiresorptive treatment on nonvertebral fracture outcomes
Dawn C Mackey et al.
WHO absolute fracture risk models (FRAX): Do clinical risk factors improve fracture prediction in older women without osteoporosis?
Teresa A Hillier et al.
Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: The manitoba study
Didier Hans et al.
Prolonged antiresorptive activity of zoledronate: A randomized, controlled trial
Andrew Grey et al.
Bone material properties in actively bone‐forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once‐yearly Zoledronic acid
Sonja Gamsjaeger et al.
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane et al.
JBMR Classics
Bone Histomorphometry: Standardization of Nomenclature, Symbols, and Units: Report of the ASBMR Histomorphometry Nomenclature Committee
Parfitt, AM et al.
Vertebral Fracture Assessment Using a Semiquantitative Technique
Genant, HK et al.
How Many Women Have Osteoporosis?
Melton, LJ et al.
Patients with prior fractures have an increased risk of future fractures: A summary of the literature and statistical synthesis
Klotzbuecher, CM et al.
The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
Haussler, MR et al.
Incidence of Clinically Diagnosed Vertebral Fractures - A Population-Based Study in Rochester, Minnesota, 1985-1989
Cooper, C et al.
New Approaches For Interpreting Projected Bone Densitometry Data
Carter, DR et al.
Long-Term Fracture Prediction by Bone-Mineral Assessed at Different Skeletal Sites
Melton, LJ et al.
Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
Luckman, SP et al.
Top 10 Downloads
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane et al.
Why the IOM recommendations for vitamin D are deficient
Robert P Heaney, Michael F Holick
Effect of 6-Month Whole Body Vibration Training on Hip Density, Muscle Strength, and Postural Control in Postmenopausal Women: A Randomized Controlled Pilot Study
Sabine MP Verschueren et al.
The amazing osteocyte
Lynda F Bonewald
The osteoblast: An insulin target cell controlling glucose homeostasis
Thomas L Clemens, Gerard Karsenty
The diagnosis of osteoporosis
Professor John A. Kanis et al.
Evidence-based policy on dietary calcium and vitamin D
Ian R Reid, Alison Avenell
Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research
Sundeep Khosla et al.
Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005-2025
Russel Burge et al.
Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian et al.
Parathyroid Hormone (PTH) Articles
Building bone with a SOST-PTH partnership
Natalie A Sims
Parathyroid hormone regulates fetal‐placental mineral homeostasis
Charlene S Simmonds et al.
The role of mast cells in parathyroid bone disease
Russell T Turner et al.
Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF‐1 axis is intact
Sebastien Elis et al.
Increased osteocyte death and mineralization inside bone after parathyroidectomy in patients with secondary hyperparathyroidism
Aiji Yajima et al.
Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1–associated primary hyperparathyroidism
Delmar M Lourenço et al.
Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms
Robert L Jilka et al.
Tissue-specific regulatory regions of the PTH gene localized by novel chromosome 11 rearrangement breakpoints in a parathyroid adenoma
Sanjay M Mallya et al.
Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patients
Kamyar Kalantar‐Zadeh et al.
Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1–34)] in postmenopausal osteoporosis
Felicia Cosman et al.
Differential effects of teriparatide on regional bone formation using 18 F-fluoride positron emission tomography
Michelle L Frost et al.
PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
Yumie Rhee et al.
The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates
Lei Shu et al.
Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow
Christian E Jacome‐Galarza et al.
FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH
Quan Yuan et al.
A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover
Mara J Horwitz et al.
Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian et al.
The effect of adding PTH(1–84) to conventional treatment of hypoparathyroidism: A randomized, placebo-controlled study
Tanja Sikjaer et al.
Parathyroid hormone signaling via Gαs is selectively inhibited by an NH 2 -terminally truncated Gαs: Implications for pseudohypoparathyroidism
Svetlana Puzhko et al.
Skeletal anabolism, PTH, and the bone–vascular axis
Dwight A Towler
Intermittent PTH(1–84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites
Rhonda Prisby et al.
PTH(1–84) administration reverses abnormal bone-remodeling dynamics and structure in hypoparathyroidism
Mishaela R Rubin et al.
Teriparatide increases bone mineral density in a man with osteoporosis pseudoglioma
Henrique Pierotti Arantes et al.
Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting
Verónica Alonso et al.
Vitamin D Articles 2009 - Present
Effects of 25-hydroxyvitamin D3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase
Shuo Geng et al.
The vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial
Hector F DeLuca et al.
Why the IOM recommendations for vitamin D are deficient
Robert P Heaney and Michael F Holick
Evidence-based policy on dietary calcium and vitamin D
Ian R Reid and Alison Avenell
The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: A 6-month randomized, controlled trial
Sabine MP Verschueren et al.
Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patients
Kamyar Kalantar-Zadeh et al.
Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study
Cédric Annweiler et al.
Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob/ob Mice
Kiyomi Tsuji et al.
The calcium-sensing receptor and 25-hydroxyvitamin D–1α-hydroxylase interact to modulate skeletal growth and bone turnover
Christian Richard et al.
Effect of vitamin D3 and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial—the OSTPRE-FPS
Kari Salovaara et al.
A patient with severe hypercalcemia in multiple organ dysfunction syndrome: Role of elevated circulating 1α,25(OH)2vitamin D levels
Junichiro James Kazama et al.
Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats
Akishige Hokugo et al.
A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
Masahiko Sato et al.
CDP/cut is an osteoblastic coactivator of the vitamin D receptor (VDR)
Eiji Ochiai et al.
Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D
Guy B Mulligan and Angelo Licata
Persistent secondary hyperparathyroidism and vertebral fractures in kidney transplantation: Role of calcium-sensing receptor polymorphisms and vitamin D deficiency
Sandro Giannini et al.
Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail
Shaochun Bai et al.
Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men
Jane A Cauley et al.
Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion
Francesco Bertoldo et al.
Vitamin D receptor (VDR) gene polymorphism is associated with left ventricular (LV) mass and predicts left ventricular hypertrophy (LVH) progression in end-stage renal disease (ESRD) patients
Alessandra Testa et al.
Bone mineralization defects and vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients
Matthias Priemel et al.
Low maternal vitamin D status and fetal bone development: Cohort study
Pamela Mahon et al.
Vitamin D insufficiency and skeletal development in utero
Martin Hewison and John S Adams
Effects of hPTH(1-34) Infusion on Circulating Serum Phosphate, 1,25-Dihydroxyvitamin D, and FGF23 Levels in Healthy Men
Sherri-Ann M Burnett-Bowie et al.
1α,25(OH)2 Vitamin D3 Induction of ATP Secretion in Osteoblasts
Payal Biswas and Laura P Zanello
Dietary Calcium and Serum 25-Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults
Heike A Bischoff-Ferrari et al.
Vitamin D Status, Parathyroid Function, Bone Turnover, and BMD in Postmenopausal Women With Osteoporosis: Global Perspective
Natalia O Kuchuk et al.
Compound Heterozygous Mutations in the Vitamin D Receptor in a Patient With Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets With Alopecia
Yulin Zhou et al.
Wintertime Vitamin D Supplementation Inhibits Seasonal Variation of Calcitropic Hormones and Maintains Bone Turnover in Healthy Men
Heli T Viljakainen et al.
Analysis of CYP27B1, Encoding 25-Hydroxyvitamin D-1α-Hydroxylase, as a Candidate Tumor Suppressor Gene in Primary and Severe Secondary/Tertiary Hyperparathyroidism
Kelly Lauter and Andrew Arnold
Vitamin D–Independent Therapeutic Effects of Extracellular Calcium in a Mouse Model of Adult-Onset Secondary Hyperparathyroidism
Karin Weber et al.
Basic Research Perspectives
Vitamin D and Health: Perspectives From Mice and Man
Roger Bouillon et al.
Review of Nonprimate, Large Animal Models for Osteoporosis Research
Susan Reinwald and David Burr
Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
Bart O Williams and Karl L Insogna
Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches
Joy Y. Wu et al.
Osteoclasts and Arthritis
Georg Schett and Steven L. Teitelbaum
Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF
Ernestina Schipani et al.
Spatiotemporal Delivery Strategies for Promoting Musculoskeletal Tissue Regeneration
Robert E. Guldberg
Myeloma Bone Disease
Ralph D. Sanderson and Joshua Epstein
Future of Osteoporosis Genetics: Enhancing Genome-Wide Association Studies
Charles R. Farber and Aldons J. Lusis
Of mice and (wo)men: Mouse models of breast cancer metastasis to bone
Robert H. Goldstein et al.
Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches
Joy Y. Wu et al.
Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Mary L. Bouxsein et al.
Gr-1 CD11b myeloid-derived suppressor cells: Formidable partners in tumor metastasis
Li Yang et al.
Sclerostin: A gem from the genome leads to bone-building antibodies
Chris Paszty et al.
FGF-23: More than a regulator of renal phosphate handling?
Harald Jüppner et al.
IGF-1 and bone: New discoveries from mouse models
Shoshana Yakar et al.
Osteosarcoma
Richard Gorlick and Chand Khanna
The amazing osteocyte
Lynda F Bonewald
The osteoblast: An insulin target cell controlling glucose homeostasis
Thomas L Clemens and Gerard Karsenty
FoxO1: A molecule for all seasons
Stavroula Kousteni
Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation
J Wesley Pike
Circulating osteogenic cells: Implications for injury, repair, and regeneration
Robert J Pignolo and Moustapha Kassem
Clinical Perspectives
Considerations for Development of Surrogate Endpoints for Antifracture Efficacy of New Treatments in Osteoporosis: A Perspective
Mary L Bouxsein and Pierre D Delmas
Theoretical Implications of the Biomechanical Fracture Threshold
Tony M Keaveny and Mary L Bouxsein
Bridging the Osteoporosis Quality Chasm
Jeffrey R Curtis et al.
Assessing the Clinical Utility of Serum CTX in Postmenopausal Osteoporosis and Its Use in Predicting Risk of Osteonecrosis of the Jaw
Sanford Baim and Paul D Miller
FRAX Facts
Nelson B. Watts et al.
Clinical Value of Monitoring BMD in Patients Treated With Bisphosphonates for Osteoporosis
Nelson B. Watts et al.
Following BMD in Patients on Bisphosphonates: Another Perspective
Robert A. Adler and Murray J. Favus
Atrial fibrillation and bisphosphonate therapy
Michael Pazianas et al.
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a Task Force of the American Society for Bone and Mineral Research
Elizabeth Shane et al.
The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?
Sundeep Khosla et al.
Evidence-based policy on dietary calcium and vitamin D
Ian R Reid and Alison Avenell
Why the IOM recommendations for vitamin D are deficient
Robert P Heaney and Michael F Holick
A clinician's guide to X-linked hypophosphatemia
Thomas O Carpenter et al.
Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis
Karen E Hansen et al.
Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
John P Bilezikian et al.
Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop
Sundeep Khosla et al.
Obesity and fracture in men and women: An epidemiologic perspective
Carrie M Nielson et al.
