An Endocrine Society Thematic Issue: Thyroid Disorders and Cancer 2018
January 2018
Read our special collection of journal articles published in 2016–2017, focused on thyroid disorders and cancer. Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations. Topics include controversies in the treatment of low-risk thyroid cancer, the identification of populations at risk for complications after thyroid cancer surgery, an examination of whether tumor-associated miRNAs can improve follow-up, a comprehensive look at the role of thyroid hormones in the skeleton, and more. Basic science topics include the discovery of signaling between a tumor suppressor and tumor promoter that may reveal strategies for intervention, a mouse model of the role of SB2 in thyroid biology, the use of Xenopus to examine thyroid hormone transporters, and others.
See more Endocrine Society special issues.
The Journal of Clinical Endocrinology & Metabolism
Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma
Marloes Nies, Mariëlle S. Klein Hesselink, Gea A. Huizinga, Esther Sulkers, Adrienne H. Brouwers, Johannes G.M. Burgerhof, Eveline W.C.M. van Dam, Bas Havekes, Marry M. van den Heuvel-Eibrink, Eleonora P.M. Corssmit, Leontien C.M. Kremer, Romana T. Netea-Maier, Heleen J.H. van der Pal, Robin P. Peeters, John T.M. Plukker, Cécile M. Ronckers, Hanneke M. van Santen, Wim J.E. Tissing, Thera P. Links, and Gianni Bocca
Vol. 102, Issue 4, April 2017
We studied QoL in adult survivors of pediatric DTC compared with matched controls and found an overall normal QoL in survivors. Mild impairment of QoL was seen in some domains of QoL.
Skeletal Complications and Mortality in Thyroid Cancer: A Population-Based Study
Palak Choksi, Maria Papaleontiou, Cui Guo, Francis Worden, Mousumi Banerjee, and Megan Haymart
Vol. 102, Issue 4, April 2017
Bone events in patients with thyroid cancer are a poor prognostic indicator. Patients with follicular and medullary thyroid cancers are at especially high risk for skeletal complications.
Population-Based Assessment of Complications Following Surgery for Thyroid Cancer
Maria Papaleontiou, David T. Hughes, Cui Guo, Mousumi Banerjee, and Megan R. Haymart
Vol. 102, Issue 7, July 2017
We evaluated general and thyroid surgery–specific complications. We found higher complication rates than expected; patients with older age, more comorbidities, and advanced cancer are at greatest risk.
Torie C. Plowden, Enrique F. Schisterman, Lindsey A. Sjaarda, Shvetha M. Zarek, Neil J. Perkins, Robert Silver, Noya Galai, Alan H. DeCherney, and Sunni L. Mumford
Vol. 101, Issue 6, June 2016
Among women with a history of pregnancy loss, subclinical hypothyroidism or thyroid autoimmunity were not associated with fecundity, pregnancy loss, or live birth.
Elizabeth K. Cahoon, Eldar A. Nadyrov, Olga N. Polyanskaya, Vasilina V. Yauseyenka, Ilya V. Veyalkin, Tamara I. Yeudachkova, Tamara I. Maskvicheva, Victor F. Minenko, Wayne Liu, Vladimir Drozdovitch, Kiyohiko Mabuchi, Mark P. Little, Lydia B. Zablotska, Robert J. McConnell, Maureen Hatch, Kamau O. Peters, Alexander V. Rozhko, and Alina V. Brenner
Vol. 102, Issue 7, July 2017
We screened 11,970 adults exposed to internal I-131 in childhood for thyroid nodules. Dose was associated with increased risk of neoplastic thyroid nodules of any size and large nonneoplastic nodules.
Endocrine Reviews
Controversies in the Management of Low-Risk Differentiated Thyroid Cancer
Megan R. Haymart, Nazanene H. Esfandiari, Michael T. Stang, and Julia Ann Sosa
Vol. 38, Issue 4, August 2017
In this review, we evaluated the current management of low-risk differentiated thyroid cancer and identified areas of controversy.
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
J.H. Duncan Bassett and Graham R. Williams
Vol. 37, Issue 2, April 2016
This review provides a comprehensive examination of the critical role that thyroid hormones play during development.
Journal of the Endocrine Society
Francesca Rosignolo, Marialuisa Sponziello, Laura Giacomelli, Diego Russo, Valeria Pecce, Marco Biffoni, Rocco Bellantone, Celestino Pio Lombardi, Livia Lamartina, Giorgio Grani, Cosimo Durante, Sebastiano Filetti, and Antonella Verrienti
Vol. 1, Issue 1, January 2017
Analysis of miRNA levels in pre- and postoperative serum samples from PTC patients reveals possible associations between postoperative changes in miR-146a-5p and miR-221-3p and clinical outcome.
Rising Thyroid Cancer Incidence in Southern India: An Epidemic of Overdiagnosis?
Indu Elizabeth Mathew and Aju Mathew
Vol. 1, Issue 5, May 2017
Rising thyroid cancer rates in developed countries are attributed to overdiagnosis. We report rising trends in cancer incidence that are likely due to overdiagnosis in a region in southern India.
Carla Moran, Abdelhadi M. Habeb, George J. Kahaly, Christoph Kampmann, Marina Hughes, Jan Marek, Odelia Rajanayagam, Adam Kuczynski, Faraneh Vargha-Khadem, Mofeed Morsy, Amaka C. Offiah, Ken Poole, Kate Ward, Greta Lyons, David Halsall, Lol Berman, Laura Watson, David Baguley, John Mollon, Anthony T. Moore, Graham E Holder, Mehul Dattani, and Krishna Chatterjee
Vol. 1, Issue 9, September 2017
A child with severe resistance to thyroid hormone, homozygosity for mutation in thyroid hormone receptor β and cardiomyopathy was treated successfully with a combination of TRIAC and carbimazole.
Endocrinology
Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency
Jiao Fu, Haruki Fujisawa, Benjamin Follman, Xiao-Hui Liao, and Alexandra M Dumitrescu
Vol. 158, Issue 12, December 2017
This article characterizes the Sbp2 iCKO mouse model that replicates the phenotype of SBP2 deficiency and represents an important tool for investigating selenoprotein biology relevant to human disease.
Frances E. Carr, Phillip W.L. Tai, Michael S. Barnum, Noelle E. Gillis, Katherine G. Evans, Thomas H. Taber, Jeffrey H. White, Jennifer A. Tomczak, Diane M. Jaworski, Sayyed K. Zaidi, Jane B. Lian, Janet L. Stein, and Gary S. Stein
Vol. 157, Issue 8, August 2016
Identification of a functional novel signaling pathway in thyroid cancer elucidates the relationship between TRβ and Runx2 and provides putative strategies for future targeting therapies.
Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1
Bilal B. Mughal, Michelle Leemans, Elaine C. Lima de Souza, Sébastien le Mevel, Petra Spirhanzlova, Theo J. Visser, Jean-Baptiste Fini, and Barbara A. Demeneix
Vol. 158, Issue 8, August 2017
Xenopus thyroid hormone transporters mct8 and oatp1c1 display high sequence homology to human proteins, similar transport capacities, and dynamic spatial and temporal brain-specific expressions.
Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature
Frédéric Flamant, Sheue-Yann Cheng, Anthony N. Hollenberg, Lars C. Moeller, Jacques Samarut, Fredric E. Wondisford, Paul M. Yen, and Samuel Refetoff
Vol. 158, Issue 7, July 2017
A classification of thyroid hormone signaling into four distinct types is proposed, to replace the confusing “genomic” vs “nongenomic” designation.
