An Endocrine Society Thematic Issue: Nuclear Receptor Biology 2018

September 2018

Read our special collection of journal articles, published between 2011–2018, spanning a variety of nuclear receptor and hormonal signaling research along with highlights from speakers at the 8th Great Lakes Nuclear Receptor Conference. Curation of the collection was guided by citations, Altmetric Attention Scores, and Featured Article designations.

Research articles investigate the role of nuclear receptors in the development of disease; examine species-specific differences in transcription factor binding and function; identify the molecular chaperone, FKBP51, as a regulator of PPARγ in white adipose tissue; and identify FXR as a gut-liver metabolic regulator of FGF15/19. Additional research articles study the role of estrogens in neurotransmission within the cerebellum, identify the cistrome and transcriptome of FOXO1 and its transcriptional regulation of the progesterone receptor, detail the importance of sequencing constraints in nuclear receptor binding, investigate the role of nuclear receptors as molecular sensors of environmental chemicals, and much more. There are several review articles in this collection that examine posttranslational modifications that affect lipid-regulated nuclear receptors, the p160 family of nuclear receptor coactivators and their involvement in diverse physiological processes, how steroid hormones can regulate stem cells using the prostate as a model, and others.

See more Endocrine Society special issues.

Endocrinology

Local Estrogen Synthesis Regulates Parallel Fiber-Purkinje Cell Neurotransmission Within the Cerebellar Cortex

en.2018-00039 Valerie L. Hedges, Gang Chen, Lei Yu, Amanda A. Krentzel, Joseph R. Starrett, Jing-Ning Zhu, Piratheepan Suntharalingam, Luke Remage-Healey, Jian-Jun Wang, Timothy J. Ebner, and Paul G. Mermelstein

Vol. 159, Issue 3, March 2018, DOI 10.1210/en.2018-00039

Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage

en.2017-00348 Bassem M. Shoucri, Eric S. Martinez, Timothy J. Abreo, Victor T. Hung, Zdena Moosova, Toshi Shioda, and Bruce Blumberg

Vol. 158, Issue 10, October 2017, DOI 10.1210/en.2017-00348

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

en.2017-00468 Laurel A. Coons, Sylvia C. Hewitt, Adam B. Burkholder, Donald P. McDonnell, and Kenneth S. Korach

Vol. 158, Issue 10, October 2017, DOI 10.1210/en.2017-00468

Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate Cancer

en.2017-00109 Yeung Ho and Scott M. Dehm

Vol. 158, Issue 6, June 2017, DOI 10.1210/en.2017-00109

Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism

en.2016-1577 Natalia Becares, Matthew C. Gage, and Inés Pineda-Torra

Vol. 158, Issue 2, February 2017, DOI 10.1210/en.2016-1577

FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone

en.2015-1996 Lance A. Stechschulte, Bin Qiu, Manya Warrier, Terry D. Hinds, Man Zhang, Hao Gu, Yuxue Xu, Saja S. Khuder, Lucia Russo, Sonia M. Najjar, Beata Lecka-Czernik, Weidong Yong, and Edwin R. Sanchez

Vol. 157, Issue 10, October 2017, DOI 10.1210/en.2015-1996

Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia

en.2015-1312 Magdalena M. Grabowska, Stephen M. Kelly, Amy L. Reese, Justin M. Cates, Tom C. Case, Jianghong Zhang, David J. DeGraff, Douglas W. Strand, Nicole L. Miller, Peter E. Clark, Simon W. Hayward, Richard M. Gronostajski, Philip D. Anderson, and Robert J. Matusik

Vol. 157, Issue 3, March 2016, DOI 10.1210/en.2015-1312

Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives

en.2015-1350 Philippe Grandjean, Robert Barouki, David C. Bellinger, Ludwine Casteleyn, Lisa H. Chadwick, Sylvaine Cordier, Ruth A. Etzel, Kimberly A. Gray, Eun-Hee Ha, Claudine Junien, Margaret Karagas, Toshihiro Kawamoto, B. Paige Lawrence, Frederica P. Perera, Gail S. Prins, Alvaro Puga, Cheryl S. Rosenfeld, David H. Sherr, Peter D. Sly, William Suk, Qi Sun, Jorma Toppari, Peter van den Hazel, Cheryl L. Walker, and Jerrold J. Heindel

Vol. 2016, Issue 1, January 2016, DOI 10.1210/en.2015-1350

Stem Cells as Hormone Targets That Lead to Increased Cancer Susceptibility

en.2015-1357 Gail S. Prins, Esther L. Calderon-Gierszal, and Wen-Yang Hu

Vol. 156, Issue 10, October 2015, DOI 10.1210/en.2015-1357

Journal of the Endocrine Society

Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals

js.2017-00406 Rafah Mackeh, Alexandra K. Marr, Soha R. Dargham, Najeeb Syed, Khalid A. Fakhro, and Tomoshige Kino

Vol. 2, Issue 1, January 2018, DOI 10.1210/js.2017-00406

Molecular Endocrinology

FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho

me.2015-1226 Ting Fu, Young-Chae Kim, Sangwon Byun, Dong-Hyun Kim, Sunmi Seok, Kelly Suino-Powell, H. Eric Xu, Byron Kemper, and Jongsook Kim Kemper

Vol. 30, Issue 1, January 2016, DOI 10.1210/me.2015-1226

Minireview: Deciphering the Cellular Functions of PELP1

me.2015-1049 Preethi Ravindranathan, Carol A. Lange, and Ganesh V. Raj

Vol. 29, Issue 9, September 2015, DOI 10.1210/me.2015-1049

Minireview: Nuclear Receptor Coregulators of the p160 Family: Insights into Inflammation and Metabolism

me.2015-1005 David A. Rollins, Maddalena Coppo, and Inez Rogatsky

Vol. 29, Issue 4, April 2015, DOI 10.1210/me.2015-1005

NFI Transcription Factors Interact with FOXA1 to Regulate Prostate-Specific Gene Expression

me.2013-1213 Magdalena M. Grabowska, Amicia D. Elliott, David J. DeGraff, Philip D. Anderson, Govindaraj Anumanthan, Hironobu Yamashita, Qian Sun, David B. Friedman, David L. Hachey, Xiuping Yu, Jonathan H. Sheehan, Jung-Mo Ahn, Ganesh V. Raj, David W. Piston, Richard M. Gronostajski, and Robert J. Matusik