An Endocrine Society Thematic Issue: Endocrinology Awareness 2018
March 2018
Read our special collection of journal articles published in 2017–2018, focused on increasing endocrinology awareness of a variety of important topics. Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations. Clinically relevant topics include transgender health, with a comprehensive analysis of endocrine treatment for gender dysphoria and an evaluation of the current status of transgender care and training programs, the relationship between obesity, diabetes, and gut microbiota, dietary interventions that induce ketosis, and others. Basic science articles highlight the role of sex-hormone binding globulin in NAFLD development, hormonal regulation of circadian clocks, the importance of sequencing constraints in nuclear receptor binding, the continued evolution of nuclear receptor genes, and much more.
See more Endocrine Society special issues.
The Journal of Clinical Endocrinology & Metabolism
Wylie C. Hembree, Peggy T. Cohen-Kettenis, Louis Gooren, Sabine E. Hannema, Walter J. Meyer, M. Hassan Murad, Stephen M. Rosenthal, Joshua D. Safer, Vin Tangpricha, and Guy G. T’Sjoen
Vol. 102, Issue 11, November 2017, DOI 10.1210/jc.2017-01658
Gender affirmation is multidisciplinary treatment. Gender-dysphoric/gender-incongruent persons seek and/or are referred to endocrinologists to develop the physical characteristics of the affirmed gender.
Caroline Davidge-Pitts, Todd B. Nippoldt, Ann Danoff, Lauren Radziejewski, and Neena Natt
Vol. 102, Issue 4, April 2017, DOI 10.1210/jc.2016-3007
We studied education and practice of transgender health and found low confidence in management of nonhormonal topics. Barriers to providing education included lack of faculty interest or expertise.
Connection between BMI related plasma metabolite profile and gut microbiota
Filip Ottosson, Louise Brunkwall, Ulrika Ericson, Peter M. Nilsson, Peter Almgren, Céline Fernandez, Olle Melander, and Marju Orho-Melander
First published online Feb. 1, 2018, DOI 10.1210/jc.2017-02114
We identify metabolites associated with BMI. The BMI related metabolites were connected to four microbiota genera, suggesting a mediating role of the metabolites in the microbiota obesity relation.
Yardena Arnoni-Bauer, Atira Bick, Noa Raz, Tal Imbar, Shoshana Amos, Orly Agmon, Limor Marko, Netta Levin, and Ram Weiss
Vol. 102, Issue 9, September 2017, DOI 10.1210/jc.2016-3921
Eating patterns peak at midluteal compared with follicular phase. Increased attention and reward brain region activation is associated with sex hormones and explains this variability.
Miao Liu, Jianhua Wang, Jing Zeng, Xiutang Cao, and Yao He
Vol. 102, Issue 4, April 2017, DOI 10.1210/jc.2016-3440
This is a large cohort study based on elderly, and results showed that there is an independent association between NAFLD and both diabetes and prediabetes, which was closely related to BMI changes.
Endocrine Reviews
Evaluating Causality of Gut Microbiota in Obesity and Diabetes in Humans
Abraham S. Meijnikman, Victor E. Gerdes, Max Nieuwdorp, and Hilde Herrema
First published online Dec. 22, 2017, DOI 10.1210/jc.2017-00192
This review discusses the causal evidence for gut microbiota driving disease states in humans and the challenging aspects in determining causality.
Linking Stress and Infertility: A Novel Role for Ghrelin
Luba Sominsky, Deborah M. Hodgson, Eileen A. McLaughlin, Roger Smith, Hannah M. Wall, and Sarah J Spencer
Vol. 38, Issue 5, October 2017, DOI 10.1210/jc.2016-1133
This review presents the current literature in the field of stress-induced reproductive dysfunction, and introduces a novel link between stress and infertility, the gut-derived hormone, ghrelin.
Journal of the Endocrine Society
Lisa Campo-Engelstein, Diane Chen, Arlene B. Baratz, Emilie K. Johnson, and Courtney Finlayson
Vol. 1, Issue 6, June 2017, DOI 10.1210/js.2017-00110
We examine the ethical issues of FP for pediatric DSD patients: gonadectomy, consent/assent, experimental treatment and false hope, cost, genetic transmission to offspring, and gender dysphoria.
Brianna D. Harfmann, Elizabeth A. Schroder, Jonathan H. England, Natalie J. Senn, Philip M. Westgate, Karyn A. Esser, and Philip A. Kern
Vol. 1, Issue 7, July 2017, DOI 10.1210/js.2017-00086
To determine the relationship between metabolic factors and circadian parameters, fasting blood labs and wrist temperature data were collected. Statistical analysis was performed and revealed triglycerides as a primary predictor.
Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals
Rafah Mackeh, Alexandra K Marr, Soha R Dargham, Najeeb Syed, Khalid A Fakhro, and Tomoshige Kino
Vol. 2, Issue 1, January 2018, DOI 10.1210/js.2017-00406
Human NR SNV analysis revealed persisting evolutional selection in humans. Gene age and a potential to new ligand adaptation, but not current functional diversity, are major determinants of NR SNVs.
Signe Altmäe, Raquel Mendoza-Tesarik, Carmen Mendoza, Nicolas Mendoza Francesco Cucinelli, and Jan Tesarik
Vol. 2, Issue 1, January 2018, DOI 10.1210/js.2017-00359
Growth hormone administration improves pregnancy and birth rates among infertile women experiencing repeated implantation failure after receiving donated oocytes.
Endocrinology
Laurel A. Coons, Sylvia C. Hewitt, Adam B. Burkholder, Donald P. McDonnell, and Kenneth S. Korach
Vol. 158, Issue 10, October 2017, DOI 10.1210/en.2017-00468
DNA sequence constraints define functionally active steroid nuclear receptor gene regulatory elements in the genome, named nuclear receptor functional enhancers.
Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development
Cristina Saez-Lopez, Anna Barbosa-Desongles, Cristina Hernandez, Roger A. Dyer, Sheila M. Innis, Rafael Simó, and David M. Selva
Vol. 158, Issue 3, March 2017, DOI 10.1210/en.2016-1668
In this study, the effect of overexpressing human sex hormone-binding globulin (SHBG) in mouse models of NAFLD was examined and found to significantly reduce liver fat.
Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans
Frédéric Gachon, Ursula Loizides-Mangold, Volodymyr Petrenko, and Charna Dibner
Vol. 158, Issue 5, May 2017, DOI 10.1210/en.2017-00218
This review summarizes recent findings on the molecular and cellular makeup of the circadian timing system and its implications in temporal coordination of glucose metabolism in health and disease.
Karen K. Ryan, Amy E. B. Packard, Karlton R. Larson, Jayna Stout, Sarah M. Fourman, Abigail M. K. Thompson, Kristen Ludwick, Kirk M. Habegger, Kerstin Stemmer, Nobuyuki Itoh, Diego Perez-Tilve, Matthias H. Tschöp, Randy J Seeley, and Yvonne M Ulrich-Lai
Vol. 159, Issue 1, January 2018, DOI 10.1210/en.2017-00486
Inducing dietary ketosis by two distinct mechanisms (one acute and one chronic) results in HPA axis activation, and these HPA effects are attenuated in mice that lack FGF21.
The Diverse Metabolic Roles of Peripheral Serotonin
Alyce M. Martin, Richard L. Young, Lex Leong, Geraint B. Rogers, Nick J. Spencer, Claire F. Jessup, Damien J. Keating
Vol. 158, Issue 5, May 2017, DOI 10.1210/en.2016-1839
Review of the emerging endocrine roles of peripheral serotonin.
