Thematic Issue: Thyroid Disease 2020
March 2020
Read our special collection of journal articles, published in 2019-2020, focused on thyroid disease! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
Groeneweg and colleagues discuss in Endocrine Reviews recent important gains in understanding of thyroid hormone transporters, where Cabanillas and colleagues describe new-generation targeted therapies for thyroid cancer. In the same journal, Virili and coauthors discuss the common problem of gastrointestinal malabsorption of therapeutic oral T4.
In Endocrinology, Houbrechts and coauthors established that in zebrafish, knockouts for the major thyroid hormone-activating enzyme have only transient hyperglycemia, which is of interest in light of the known association of inactivating mutations in the enzyme with type 2 diabetes in humans and mice. Ruis and coauthors established that in rats, polybrominated diphenyl ethers affected thyroid hormone levels in the dam and in the placenta in a sex-specific manner; they also cited some human evidence of a disrupting effect.
In JCEM, Grani and coauthors discuss the circumstances in which repeated neck ultrasound might be needed for thyroid cancer patients with no evidence of disease. Yan and colleagues document a worrisome increase in the incidence of all types of thyroid cancer in California, using state registry data. Barres et al. establish in a retrospective study that stimulated thyroglobulin and thyroglobulin reduction index can predict long-term remission in patients with differentiated thyroid cancer.
In JES, Gammons and colleagues analyze referrals to pediatric endocrinologists for elevated thyroid stimulating hormone, concluding that elevations slightly above the reference range should not in themselves justify referral. Silva de Morais and coauthors conclude that Hashimoto thyroiditis increases the risk of malignancy in patients presenting for nodule evaluation. And Calsolaro and colleagues discuss the challenges of treating hypothyroidism in the elderly.
Endocrine Reviews
Thyroid Hormone Transporters
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone.
Targeted Therapy for Advanced Thyroid Cancer: Kinase Inhibitors and Beyond
The treatment of advanced thyroid cancer has undergone rapid evolution in the last decade, with multiple kinase inhibitor drug approvals for each subtype of thyroid cancer and a number of other commercially available drugs that have been studied for this indication.
Gastrointestinal Malabsorption of Thyroxine
Levothyroxine, a largely prescribed drug with a narrow therapeutic index, is often a lifelong treatment.
Endocrinology
Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish
Thyroid hormones (THs) are crucial regulators of glucose metabolism and insulin sensitivity.
PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation
During pregnancy, the supply of thyroid hormone (TH) to the fetus is critically important for fetal growth, neural development, metabolism, and maintenance of pregnancy.
The Journal of Clinical Endocrinology & Metabolism
Thyroid Cancer Patients With No Evidence of Disease
Ultrasonography (US) is considered the most sensitive tool for imaging persistent or recurrent papillary thyroid cancer (PTC) in the neck.
Rising Incidence and Incidence-Based Mortality of Thyroid Cancer in California, 2000-2017
The increased incidence of thyroid cancer globally over the past several decades is principally attributed to small, indolent papillary thyroid cancers.
Stimulated Thyroglobulin and Thyroglobulin Reduction Index Predict Excellent Response in Differentiated Thyroid Cancers
Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by high rates of disease persistence and recurrence.
Journal of the Endocrine Society
Hypothyroidism in the Elderly: Who Should Be Treated and How?
Hypothyroidism is among the most frequent chronic diseases in the elderly, and levothyroxine (L-T4) is worldwide within the 10 drugs more prescribed in the general population.
The Impact of Hashimoto Thyroiditis on Thyroid Nodule Cytology and Risk of Thyroid Cancer
The impact of Hashimoto thyroiditis (HT) on the risk of thyroid cancer and its accurate detection remains unclear.
Referrals for Elevated Thyroid Stimulating Hormone to Pediatric Endocrinologists
We aimed to determine the reproducibility of TSH testing in pediatric patients referred to pediatric endocrinologists and to identify the threshold TSH levels that would predict the presence of antithyroid autoantibodies and inform decisions by pediatric endocrinologists to initiate or continue treatment with levothyroxine.
