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Volume 158, Issue 3, 1 March 2017
Mini-Reviews
Cancer - Oncogenes
Therapeutic Implications of Epigenetic Signaling in Breast Cancer
Research has shown the link between breast cancer and epigenetic signaling. This review discusses the role of epigenetic enzymes and the clinical utility of these enzymes in breast carcinogenesis.
Neuroendocrinology
A Refill for the Brain Mineralocorticoid Receptor: The Benefit of Cortisol Add-On to Dexamethasone Therapy
News & Views
Calcium Metabolism - Bone
Genetic Knockout and Rescue Studies in Mice Unravel Abnormal Phosphorus Threshold in Hypophosphatemic Rickets
Cancer - Oncogenes
Osteoclasts Control Lipid Secretion to Regulate Breast Cancer Bone Metastasis
Endocrine-Disrupting Chemicals
The “Plastic” Mother
Energy Balance - Obesity - Metabolism
PKA Differentially Regulates Adipose Depots to Control Energy Expenditure
Reproduction, Sex, and Gender
Finding the Right Balance: Androgens at the Tipping Point of Fertility and Metabolism in Women
Research Articles
Calcium Metabolism - Bone
A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice
Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis
Osteonecrosis of the Femoral Head: Lipotoxicity Exacerbation in MSC and Modifications of the Bone Marrow Fluid
Cancer - Oncogenes
Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D
Endocrine-Disrupting Chemicals
Bisphenol S (BPS) Alters Maternal Behavior and Brain in Mice Exposed During Pregnancy/Lactation and Their Daughters
Endocrine Organ Physiology and Pathophysiology
Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and Nuclear Hepatic Androgen Receptor Mechanisms
Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development
Energy Balance - Obesity - Metabolism
Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
PKA-RIIB Deficiency Induces Brown Fatlike Adipocytes in Inguinal WAT and Promotes Energy Expenditure in Male FVB/NJ Mice
General Endocrinology
Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway
Mediator complex subunit 12 (Med12) is required for regulation of human uterine fibroid cell proliferation by modulating the expression of Wnt/β-catenin and fibrosis-associated proteins.
Neuroendocrinology
Genetic Evidence for Multifactorial Control of the Reproductive Axis in Zebrafish
The Arcuate Estrogen-Regulated Transcriptome: Estrogen Response Element–Dependent and –Independent Signaling of ERα in Female Mice
Reproduction, Sex, and Gender
17β-HSD Type 12-Like Is Responsible for Maturation-Inducing Hormone Synthesis During Oocyte Maturation in Masu Salmon
We found no support for CR/20β-HSD as the catalyst for the production of DHP, but instead present compelling evidence that 17β-HSD type 12-like is the enzyme responsible for DHP synthesis.
Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence
Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters
Steroid Hormone Actions
Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases
Thyroid Function and Regulation
The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome
Sodium phenylbutyrate rescues the following monocarboxylate transporter 8 mutations associated with milder phenotypes in patients with Allan-Herndon-Dudley syndrome: L568P, L434W, R445C, L492P, S194F, S290F.