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Review
. 2011 Jun;6(2):95-102.
doi: 10.1007/s11523-011-0173-x. Epub 2011 Apr 16.

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

Hakan Cam  1 , Peter J Houghton
Affiliations
Review

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

Hakan Cam et al. Target Oncol. 2011 Jun.

Abstract

Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.

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