Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
- PMID: 20876719
- PMCID: PMC2992765
- DOI: 10.2337/db10-0253
Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
Abstract
Objective: Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure.
Research design and methods: Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.
Results: Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
Conclusions: These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.
Figures
![FIG. 1.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/2992765/bin/zdb0121063610001.gif)
![FIG. 2.](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/2992765/bin/zdb0121063610002.gif)
Similar articles
-
Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial.Obes Surg. 2019 Oct;29(10):3239-3245. doi: 10.1007/s11695-019-03976-4. Obes Surg. 2019. PMID: 31256356 Clinical Trial.
-
Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes.Am J Clin Nutr. 2013 Jul;98(1):16-24. doi: 10.3945/ajcn.113.058743. Epub 2013 May 29. Am J Clin Nutr. 2013. PMID: 23719559
-
Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota.Genome Med. 2016 Jun 15;8(1):67. doi: 10.1186/s13073-016-0312-1. Genome Med. 2016. PMID: 27306058 Free PMC article. Clinical Trial.
-
The importance of the gut microbiota after bariatric surgery.Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):590-8. doi: 10.1038/nrgastro.2012.161. Epub 2012 Aug 28. Nat Rev Gastroenterol Hepatol. 2012. PMID: 22926153 Review.
-
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.Curr Obes Rep. 2019 Sep;8(3):229-242. doi: 10.1007/s13679-019-00351-3. Curr Obes Rep. 2019. PMID: 31197613 Review.
Cited by
-
Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis.Curr Issues Mol Biol. 2024 May 8;46(5):4471-4488. doi: 10.3390/cimb46050271. Curr Issues Mol Biol. 2024. PMID: 38785539 Free PMC article. Review.
-
Vertical Sleeve Gastrectomy Reduces Gut Luminal Deoxycholic Acid Concentrations in Mice.Obes Surg. 2024 Jul;34(7):2483-2491. doi: 10.1007/s11695-024-07288-0. Epub 2024 May 22. Obes Surg. 2024. PMID: 38777944 Free PMC article.
-
Microbiota dynamics preceding bariatric surgery as obesity treatment: a comprehensive review.Front Nutr. 2024 Apr 3;11:1393182. doi: 10.3389/fnut.2024.1393182. eCollection 2024. Front Nutr. 2024. PMID: 38633602 Free PMC article. Review.
-
Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.Nutrients. 2024 Apr 5;16(7):1071. doi: 10.3390/nu16071071. Nutrients. 2024. PMID: 38613104 Free PMC article. Review.
-
Gut microbiota and therapy for obesity and type 2 diabetes.Front Endocrinol (Lausanne). 2024 Mar 26;15:1333778. doi: 10.3389/fendo.2024.1333778. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38596222 Free PMC article. Review.
References
-
- Clement K, Langin D: Regulation of inflammation-related genes in human adipose tissue. J Intern Med 2007;262:422–430 - PubMed
-
- Pradhan A: Obesity, metabolic syndrome, and type 2 diabetes: inflammatory basis of glucose metabolic disorders. Nutr Rev 2007;65:S152–156 - PubMed
-
- DiBaise JK, Zhang H, Crowell MD, Krajmalnik-Brown R, Decker GA, Rittmann BE: Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 2008;83:460–469 - PubMed
-
- Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI: An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006;444:1027–1131 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials