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Tracers are fluorescent protein ligands required for various displacement assays. Here, the authors announce a curated database named tracerDB, which will make essential tracer data, contributed by the worldwide research community, easily available and searchable.
Using a joint species distribution model fitted to 61 species, this study shows that the habitat of Arctic fish might be hugely reduced in the next decades, and potentially eliminated from the Barents Sea. Boreal species are shown to expand their habitat, leading to increased species richness in the area and a diversification of dominance, but this might not increase overall biomass.
Adherens junctions mediate force transmission and connect the cytoskeleton of adjacent cells. This study demonstrates that force transmission can be achieved through direct and functional β-catenin/vinculin interaction in the absence of α-catenin.
Wearable contact lens can be used for health monitoring applications such as intraocular pressure for glaucoma and postoperative myopia. Here, Liu et al. report a neuroprosthetic contact lens-enabled sensorimotor system with a sensitivity of 12.52 mV mmHg−1 for point-of-care monitoring and real-time display.
Direct reduction of unactivated alkyl halides for C(sp3)-N couplings under mild conditions presents a significant challenge in organic synthesis. Here the authors introduce an in situ formed pyridyl carbene-ligated copper (I) catalyst that is capable of abstracting halide atom and generating alkyl radicals for general C(sp3)-N couplings under visible light.
The study reveals anoxic leaching in ancient Martian terrains occurred during seasonal freeze-thaw cycles. Findings suggest that gradual atmospheric oxidation drove Mars to become cold and bipolar in its early history.
The transcription factor GATA3 is enhanced in innate lymphoid type 2 cells (ILC2). Here the authors characterize the super enhancer regions of GATA3 and show that these enhancers are required to drive GATA3 expression and stage specific ILC2 development.
Here, the authors identify SNPs, genes, pathways, cells and tissues shared between abdominal aortic aneurysm and 21 cardiometabolic traits, generating a reference for common mechanisms and identifying drugs for comorbid conditions.
Natural antimicrobial peptides and enzymes are good candidates for application but suffer from low stability. Here, the authors report on biomimetic self-assembling peptides which mimic both antimicrobial peptide and enzyme functionality, demonstrating application against fungal infection.
The authors show that real and hypothetical economic segregation is related to reduced concerns about inequality and that this is true even when holding constant both actual and perceived gaps between people of different economic means.
Mechanochromic photonic crystals are extremely attractive due to their force-dependent structural colors yet are limited by unrecordable color and unsatisfactory performances. Here, the authors report a thermal-responsive mechanochromic photonic crystal with multicolor recordability-erasability.
Pacific Biosciences (PacBio) High Fidelity (HiFi) long-read sequencing usually requires a relatively high amount of DNA input ( > 1 µg). Here the authors develop LILAP, a Low-Input (100 ng), Low-cost, and Amplification-free library-generation method for PacBio sequencing, enabling the generation of two high-quality individual fly genomes.
Progranulin deficiency causes untreatable neurodegenerative diseases. Here, the authors show that hematopoietic stem cell transplantation and optimized brain conditioning correct the disease phenotype in progranulin-deficient mice.
Here, authors develop SkinGPT-4, an interactive dermatology diagnostic system that uses multimodal large language models and aligns a vision transformer with Llama-2-13b-chat. Evaluated by dermatologists, it offers autonomous diagnosis and treatment recommendations.
Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype. Here, the authors show that TWEAK/Fn14 signalling promotes TNBC metastasis through extensive transcriptomic and epigenetic remodelling, highlighting it as a promising therapeutic target.
The bulk photovoltaic effect holds promise for various optoelectronic applications, but it is usually restricted to non-centrosymmetric materials operating in the visible range. Here, the authors report a surface photogalvanic effect spanning from visible to midinfrared wavelengths in a centrosymmetric topological insulator, Ag2Te.
This study on the genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies macaque models for inherited human retinal and neurodevelopment diseases.
Here the Authors showcase a microwave absorber design that combines semiconductive metal-organic frameworks with iron 2D layers, achieving ultra-broadband absorption in the whole 5 G frequencies and stable performance against various angles and polarizations.
In this study, the authors delineate a global biogeographic map for ants based on their distributions and phylogenetic relationships. They show that current biogeographic maps based on tetrapod groups fail to capture important regions for biodiversity shared by insects and plants, which are both known to possess strong ecological and evolutionary ties.
Ruthenium complexes with facially coordinating tripodal phosphine ligands are privileged catalysts for a broad range of (de-)hydrogenation-based transformations but the mechanism remains poorly understood. Here the authors present a detailed investigation on the triphos-Ru catalysed C–O bond scission on a molecular level.