Towards a biologically annotated brain connectome
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich�…
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich�…
[HTML][HTML] Toward best practices for imaging transcriptomics of the human brain
Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using noninvasive�…
investigating the molecular correlates of brain organization, as quantified using noninvasive�…
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent�…
are not well understood. Using a large neuroimaging dataset, we identified three latent�…
[HTML][HTML] A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…
White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles
GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai…�- Nature Mental�…, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric�…
disorders. This study examined white matter dysfunctions common in four major psychiatric�…
Molecular mechanisms underlying human spatial cognitive ability revealed with neurotransmitter and transcriptomic mapping
J Yang, K Chen, J Zhang, Y Ma, M Chen…�- Cerebral�…, 2023 - academic.oup.com
Mental rotation, one of the cores of spatial cognitive abilities, is closely associated with
spatial processing and general intelligence. Although the brain underpinnings of mental�…
spatial processing and general intelligence. Although the brain underpinnings of mental�…
Functional genomics and systems biology in human neuroscience
G Konopka, A Bhaduri�- Nature, 2023 - nature.com
Neuroscience research has entered a phase of key discoveries in the realm of
neurogenomics owing to strong financial and intellectual support for resource building and�…
neurogenomics owing to strong financial and intellectual support for resource building and�…
[HTML][HTML] Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance
The human brain is organized as segregation and integration units and follows complex
developmental trajectories throughout life. The cortical manifold provides a new means of�…
developmental trajectories throughout life. The cortical manifold provides a new means of�…
[HTML][HTML] Neurophysiological signatures of cortical micro-architecture
Systematic spatial variation in micro-architecture is observed across the cortex. These micro-
architectural gradients are reflected in neural activity, which can be captured by�…
architectural gradients are reflected in neural activity, which can be captured by�…
Aneuploidy effects on human gene expression across three cell types
S Liu, N Akula, PK Reardon, J Russ…�- Proceedings of the�…, 2023 - National Acad Sciences
Aneuploidy syndromes impact multiple organ systems but understanding of tissue-specific
aneuploidy effects remains limited—especially for the comparison between peripheral�…
aneuploidy effects remains limited—especially for the comparison between peripheral�…