Towards a biologically annotated brain connectome

V Bazinet, JY Hansen, B Misic�- Nature reviews neuroscience, 2023 - nature.com
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich�…

[HTML][HTML] Toward best practices for imaging transcriptomics of the human brain

A Arnatkeviciute, RD Markello, BD Fulcher, B Misic…�- Biological�…, 2023 - Elsevier
Modern brainwide transcriptional atlases provide unprecedented opportunities for
investigating the molecular correlates of brain organization, as quantified using noninvasive�…

Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder

AM Buch, PE V�rtes, J Seidlitz, SH Kim…�- Nature�…, 2023 - nature.com
The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent�…

[HTML][HTML] A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases

Y Zeighami, TE Bakken, T Nickl-Jockschat…�- PLoS�…, 2023 - journals.plos.org
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…

White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles

GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai…�- Nature Mental�…, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric�…

Molecular mechanisms underlying human spatial cognitive ability revealed with neurotransmitter and transcriptomic mapping

J Yang, K Chen, J Zhang, Y Ma, M Chen…�- Cerebral�…, 2023 - academic.oup.com
Mental rotation, one of the cores of spatial cognitive abilities, is closely associated with
spatial processing and general intelligence. Although the brain underpinnings of mental�…

Functional genomics and systems biology in human neuroscience

G Konopka, A Bhaduri�- Nature, 2023 - nature.com
Neuroscience research has entered a phase of key discoveries in the realm of
neurogenomics owing to strong financial and intellectual support for resource building and�…

[HTML][HTML] Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance

J Li, C Zhang, Y Meng, S Yang, J Xia, H Chen…�- Plos Biology, 2024 - journals.plos.org
The human brain is organized as segregation and integration units and follows complex
developmental trajectories throughout life. The cortical manifold provides a new means of�…

[HTML][HTML] Neurophysiological signatures of cortical micro-architecture

G Shafiei, BD Fulcher, B Voytek…�- Nature�…, 2023 - nature.com
Systematic spatial variation in micro-architecture is observed across the cortex. These micro-
architectural gradients are reflected in neural activity, which can be captured by�…

Aneuploidy effects on human gene expression across three cell types

S Liu, N Akula, PK Reardon, J Russ…�- Proceedings of the�…, 2023 - National Acad Sciences
Aneuploidy syndromes impact multiple organ systems but understanding of tissue-specific
aneuploidy effects remains limited—especially for the comparison between peripheral�…