[HTML][HTML] Molecular mechanisms of synaptic dysregulation in fragile X syndrome and autism spectrum disorders

M Telias�- Frontiers in molecular neuroscience, 2019 - frontiersin.org
Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders�…

The state of synapses in fragile X syndrome

BE Pfeiffer, KM Huber�- The Neuroscientist, 2009 - journals.sagepub.com
Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a
leading genetic cause of autism. There is increasing evidence in both FXS and other forms�…

Fragile X syndrome: the GABAergic system and circuit dysfunction

SM Paluszkiewicz, BS Martin…�- Developmental�…, 2011 - karger.com
Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual
disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and�…

The pathophysiology of fragile X (and what it teaches us about synapses)

AL Bhakar, G D�len, MF Bear�- Annual review of neuroscience, 2012 - annualreviews.org
Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded�…

The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome

MR Tranfaglia�- Developmental neuroscience, 2011 - karger.com
Fragile X syndrome (FXS) is the leading inherited cause of mental retardation and autism
spectrum disorders worldwide. It presents with a distinct behavioral phenotype which�…

Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure

CL Gatto, K Broadie - 2008 - journals.biologists.com
Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most
common inherited form of both mental retardation and autism spectrum disorders. The FMR1�…

Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome

PY Deng, D Sojka, VA Klyachko�- Journal of neuroscience, 2011 - Soc Neuroscience
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading genetic cause of autism. It is associated with the lack of fragile X mental retardation�…

The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao�- Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat�…

Molecular mechanisms of fragile X syndrome: a twenty-year perspective

MR Santoro, SM Bray, ST Warren�- Annual Review of Pathology�…, 2012 - annualreviews.org
Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion�…

Impaired GABA neural circuits are critical for fragile X syndrome

F Gao, L Qi, Z Yang, T Yang, Y Zhang, H Xu…�- Neural�…, 2018 - Wiley Online Library
Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by silence of
the fmr1 gene and the deficiency of Fragile X mental retardation protein (FMRP). Patients�…